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FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells.
Zhai X, Du H, Shen Y, Zhang X, Chen Z, Wang Y, Xu Z. Zhai X, et al. J Cell Sci. 2022 Aug 15;135(16):jcs259912. doi: 10.1242/jcs.259912. Epub 2022 Aug 18. J Cell Sci. 2022. PMID: 35892293
In the present work, Fchsd2 knockout mice were established to investigate the role of FCHSD2 in hearing. ...Noise exposure causes robust stereocilia degeneration as well as enhanced hearing threshold elevation in Fchsd2 knockout mice. Lastly, Fchsd2/Cd …
In the present work, Fchsd2 knockout mice were established to investigate the role of FCHSD2 in hearing. ...Noise exposure cau …
FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation.
Zhai X, Shen Y, Zhang X, Li T, Lu Q, Xu Z. Zhai X, et al. Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119134. doi: 10.1016/j.bbamcr.2021.119134. Epub 2021 Sep 11. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 34520816 Free article.
Our data suggest that FCHSD2 cooperates with CDC42 and N-WASP in regulating apical cell protrusion formation. ...Interestingly, the F-BAR domain of FCHSD2 induces lateral cell protrusion formation independently of N-WASP. ...
Our data suggest that FCHSD2 cooperates with CDC42 and N-WASP in regulating apical cell protrusion formation. ...Interestingly, the F …
FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking.
Xiao GY, Schmid SL. Xiao GY, et al. PLoS Biol. 2020 Jul 17;18(7):e3000778. doi: 10.1371/journal.pbio.3000778. eCollection 2020 Jul. PLoS Biol. 2020. PMID: 32678845 Free PMC article.
The small GTPase, Ras-related protein Rab-7A (Rab7), is essential for the FCHSD2 depletion-induced effects. Correspondingly, FCHSD2 loss correlates to higher tumor grades of NSCLC. Clinically, NSCLC patients expressing high FCHSD2 exhibit elevated survival, w …
The small GTPase, Ras-related protein Rab-7A (Rab7), is essential for the FCHSD2 depletion-induced effects. Correspondingly, FCHSD …
Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2.
Wang H, Zhao D, Du H, Zhai X, Wu S, Lin L, Xu Z, Lu Q. Wang H, et al. Biochem J. 2022 Jun 30;479(12):1393-1405. doi: 10.1042/BCJ20220147. Biochem J. 2022. PMID: 35695292 Free PMC article.
However, the molecular mechanism of how PDZD7 governs stereociliary development remains unknown. Here, we reported a novel PDZD7-binding partner, FCHSD2, identified by yeast two-hybrid screening. FCHSD2 was reported to be expressed in hair cell, where it co-operated …
However, the molecular mechanism of how PDZD7 governs stereociliary development remains unknown. Here, we reported a novel PDZD7-binding par …
FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.
Han Y, Cui J, Lu Y, Sue S, Arpaia E, Mak TW, Minden MD. Han Y, et al. Leuk Res. 2012 Nov;36(11):1339-46. doi: 10.1016/j.leukres.2012.06.011. Epub 2012 Aug 16. Leuk Res. 2012. PMID: 22902056
In the present study, we found that FCHSD2 knockdown by shRNA could enhance chemosensitivity of U937 cells. ...In conclusion, our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for AML patient. The determination of FCHSD2 expression …
In the present study, we found that FCHSD2 knockdown by shRNA could enhance chemosensitivity of U937 cells. ...In conclusion, our stu …
The mammalian endocytic cytoskeleton.
Abouelezz A, Almeida-Souza L. Abouelezz A, et al. Eur J Cell Biol. 2022 Apr;101(2):151222. doi: 10.1016/j.ejcb.2022.151222. Epub 2022 Apr 3. Eur J Cell Biol. 2022. PMID: 35413660 Free article. Review.
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.
Hu M, Cebola I, Carrat G, Jiang S, Nawaz S, Khamis A, Canouil M, Froguel P, Schulte A, Solimena M, Ibberson M, Marchetti P, Cardenas-Diaz FL, Gadue PJ, Hastoy B, Almeida-Souza L, McMahon H, Rutter GA. Hu M, et al. Cell Rep. 2021 Feb 2;34(5):108703. doi: 10.1016/j.celrep.2021.108703. Cell Rep. 2021. PMID: 33535042 Free PMC article.
Expression of both STARD10 and FCHSD2 is reduced in cells harboring CRISPR deletions, and lower expression of STARD10 and FCHSD2 is associated, the latter nominally, with the possession of risk variant alleles in human islets. Finally, CRISPR-Cas9-mediated loss of S …
Expression of both STARD10 and FCHSD2 is reduced in cells harboring CRISPR deletions, and lower expression of STARD10 and FCHSD2 …
FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.
Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S, Xu Z. Cao H, et al. PLoS One. 2013;8(2):e56516. doi: 10.1371/journal.pone.0056516. Epub 2013 Feb 20. PLoS One. 2013. PMID: 23437151 Free PMC article.
Mammalian FCHSD1 and FCHSD2 are homologous proteins containing an amino-terminal F-BAR domain and two SH3 domains near their carboxyl-termini. We report here that FCHSD1 and FCHSD2 are expressed in mouse cochlear sensory hair cells. FCHSD1 mainly localizes to the cu …
Mammalian FCHSD1 and FCHSD2 are homologous proteins containing an amino-terminal F-BAR domain and two SH3 domains near their carboxyl …
Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.
Xiao GY, Mohanakrishnan A, Schmid SL. Xiao GY, et al. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9570-E9579. doi: 10.1073/pnas.1810209115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249660 Free PMC article.
Our data suggest that ERK1/2 phosphorylation activates FCHSD2 and regulates EGF receptor (EGFR) endocytic trafficking as well as downstream signaling activities. ...The expression level of FCHSD2 is positively correlated with higher NSCLC patient survival rates, sug …
Our data suggest that ERK1/2 phosphorylation activates FCHSD2 and regulates EGF receptor (EGFR) endocytic trafficking as well as down …
Identification and characterization of human FCHSD1 and FCHSD2 genes in silico.
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2004 May;13(5):749-54. Int J Mol Med. 2004. PMID: 15067381
KIAA0769 (NM_014824.1), encoding N-terminally truncated 684-aa protein, was an aberrant human FCHSD2 cDNA with a frame shift due to skipping of 98-bp exon 2. Complete coding sequence of human FCHSD2 cDNA was determined by assembling CF995054 EST and KIAA0769 cDNA. . …
KIAA0769 (NM_014824.1), encoding N-terminally truncated 684-aa protein, was an aberrant human FCHSD2 cDNA with a frame shift due to s …
32 results