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Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Fensome A, Bender R, Chopra R, Cohen J, Collins MA, Hudak V, Malakian K, Lockhead S, Olland A, Svenson K, Terefenko EA, Unwalla RJ, Wilhelm JM, Wolfrom S, Zhu Y, Zhang Z, Zhang P, Winneker RC, Wrobel J. Fensome A, et al. J Med Chem. 2005 Aug 11;48(16):5092-5. doi: 10.1021/jm050358b. J Med Chem. 2005. PMID: 16078826
New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.
Fensome A, Bender R, Cohen J, Collins MA, Mackner VA, Miller LL, Ullrich JW, Winneker R, Wrobel J, Zhang P, Zhang Z, Zhu Y. Fensome A, et al. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3487-90. doi: 10.1016/s0960-894x(02)00746-1. Bioorg Med Chem Lett. 2002. PMID: 12419390
Novel pyrrole-containing progesterone receptor modulators.
Collins MA, Hudak V, Bender R, Fensome A, Zhang P, Miller L, Winneker RC, Zhang Z, Zhu Y, Cohen J, Unwalla RJ, Wrobel J. Collins MA, et al. Among authors: fensome a. Bioorg Med Chem Lett. 2004 May 3;14(9):2185-9. doi: 10.1016/j.bmcl.2004.02.054. Bioorg Med Chem Lett. 2004. PMID: 15081005
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
Zhang Z, Olland AM, Zhu Y, Cohen J, Berrodin T, Chippari S, Appavu C, Li S, Wilhem J, Chopra R, Fensome A, Zhang P, Wrobel J, Unwalla RJ, Lyttle CR, Winneker RC. Zhang Z, et al. Among authors: fensome a. J Biol Chem. 2005 Aug 5;280(31):28468-75. doi: 10.1074/jbc.M504144200. Epub 2005 Jun 3. J Biol Chem. 2005. PMID: 15937332 Free article.
52 results