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SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules.
Elhemely MA, Belgath AA, El-Sayed S, Burusco KK, Kadirvel M, Tirella A, Finegan K, Bryce RA, Stratford IJ, Freeman S. Elhemely MA, et al. Among authors: finegan k. J Med Chem. 2022 Mar 24;65(6):4783-4797. doi: 10.1021/acs.jmedchem.1c01936. Epub 2022 Mar 15. J Med Chem. 2022. PMID: 35290041 Free PMC article.
Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
Zhang J, Pearson AJ, Sabherwal N, Telfer BA, Ali N, Kan K, Xu Q, Zhang W, Chen F, Li S, Wang J, Gray NS, Risa-Ebrí B, Finegan KG, Cross MJ, Giurisato E, Whitmarsh AJ, Tournier C. Zhang J, et al. Among authors: finegan kg. Cancer Res Commun. 2022 Mar 10;2(3):131-145. doi: 10.1158/2767-9764.CRC-21-0089. Cancer Res Commun. 2022. PMID: 36466034 Free PMC article.
Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis.
Giurisato E, Lonardi S, Telfer B, Lussoso S, Risa-Ebrí B, Zhang J, Russo I, Wang J, Santucci A, Finegan KG, Gray NS, Vermi W, Tournier C. Giurisato E, et al. Among authors: finegan kg. Cancer Res. 2020 Aug 15;80(16):3319-3330. doi: 10.1158/0008-5472.CAN-19-2416. Epub 2020 Jun 19. Cancer Res. 2020. PMID: 32561530 Free PMC article.
ERK5 is a critical mediator of inflammation-driven cancer.
Finegan KG, Perez-Madrigal D, Hitchin JR, Davies CC, Jordan AM, Tournier C. Finegan KG, et al. Cancer Res. 2015 Feb 15;75(4):742-53. doi: 10.1158/0008-5472.CAN-13-3043. Epub 2015 Feb 3. Cancer Res. 2015. PMID: 25649771 Free PMC article.
27 results