Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2011 1
2014 1
2015 2
2016 2
2017 1
2018 1
2019 3
2020 3
2021 2
2022 1
2023 3
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

19 results

Results by year

Filters applied: . Clear all
Page 1
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA.
Grindheim AK, Patil SS, Nebigil CG, Désaubry L, Vedeler A. Grindheim AK, et al. Front Cell Dev Biol. 2023 May 12;11:1094941. doi: 10.3389/fcell.2023.1094941. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37250892 Free PMC article.
AnxA2 regulates the translation of its cognate mRNA by a feed-back mechanism, which can partly be relieved by FL3. Results obtained using the holdup chromatographic retention assay results suggest that AnxA2 interacts transiently with eIF4E (possibly eIF4G) and PABP in an …
AnxA2 regulates the translation of its cognate mRNA by a feed-back mechanism, which can partly be relieved by FL3. Results obtained u …
Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo.
Liu J, Zhang R, Su T, Zhou Q, Gao L, He Z, Wang X, Zhao J, Xing Y, Sun F, Cai W, Wang X, Han J, Qin R, Désaubry L, Han B, Chen W. Liu J, et al. J Exp Clin Cancer Res. 2023 May 20;42(1):128. doi: 10.1186/s13046-023-02695-0. J Exp Clin Cancer Res. 2023. PMID: 37210546 Free PMC article.
Prohibitin (PHB1) is a multifunctional chaperone/scaffold protein that is upregulated in various cancers and plays a pro-cancer role. FL3 is a synthetic flavagline drug that inhibits cancer cell proliferation by targeting PHB1. ...Mechanically, we demonstrated that …
Prohibitin (PHB1) is a multifunctional chaperone/scaffold protein that is upregulated in various cancers and plays a pro-cancer role. FL3 …
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.
Largeot A, Klapp V, Viry E, Gonder S, Fernandez Botana I, Blomme A, Benzarti M, Pierson S, Duculty C, Marttila P, Wierz M, Gargiulo E, Pagano G, An N, El Hachem N, Perez Hernandez D, Chakraborty S, Ysebaert L, François JH, Cortez Clemente S, Berchem G, Efremov DG, Dittmar G, Szpakowska M, Chevigné A, Nazarov PV, Helleday T, Close P, Meiser J, Stamatopoulos B, Désaubry L, Paggetti J, Moussay E. Largeot A, et al. Blood. 2023 Jun 29;141(26):3166-3183. doi: 10.1182/blood.2022017839. Blood. 2023. PMID: 37084385 Free PMC article.
Here, we show that both human and murine chronic lymphocytic leukemia (CLL) cells display a high translation rate, which is inhibited by the synthetic flavagline FL3, a prohibitin (PHB)-binding drug. A multiomics analysis performed in samples from patients with CLL …
Here, we show that both human and murine chronic lymphocytic leukemia (CLL) cells display a high translation rate, which is inhibited by the …
Correction: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45alpha pathway.
Yuan G, Chen X, Liu Z, Wei W, Shu Q, Abou-Hamdan H, Jiang L, Li X, Chen R, Désaubry L, Zhou F, Xie D. Yuan G, et al. J Exp Clin Cancer Res. 2022 Sep 30;41(1):291. doi: 10.1186/s13046-022-02502-2. J Exp Clin Cancer Res. 2022. PMID: 36180869 Free PMC article. No abstract available.
Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells.
Tortelli TC, Tamura RE, de Souza Junqueira M, da Silva Mororó J, Bustos SO, Natalino RJM, Russell S, Désaubry L, Strauss BE, Chammas R. Tortelli TC, et al. Aging (Albany NY). 2021 Sep 16;13(18):21914-21940. doi: 10.18632/aging.203528. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34528900 Free PMC article.
Treatment with a sub-lethal dose of cisplatin increased Jarid1b expression, yet downregulated P53 levels, protecting A549Res cells from metformin-induced chemosensitization to cisplatin and favored a glycolytic phenotype. Treatment with FL3, a synthetic flavagline, …
Treatment with a sub-lethal dose of cisplatin increased Jarid1b expression, yet downregulated P53 levels, protecting A549Res cells from metf …
Correction to: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45alpha pathway.
Yuan G, Chen X, Liu Z, Wei W, Shu Q, Abou-Hamdan H, Jiang L, Li X, Chen R, Désaubry L, Zhou F, Xie D. Yuan G, et al. J Exp Clin Cancer Res. 2021 Mar 30;40(1):115. doi: 10.1186/s13046-021-01923-9. J Exp Clin Cancer Res. 2021. PMID: 34412672 Free PMC article. No abstract available.
Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes.
Harmouch E, Seitlinger J, Chaddad H, Ubeaud-Sequier G, Barths J, Saidu S, Désaubry L, Grandemange S, Massfelder T, Fuhrmann G, Fioretti F, Dontenwill M, Benkirane-Jessel N, Idoux-Gillet Y. Harmouch E, et al. Sci Rep. 2020 Aug 13;10(1):13750. doi: 10.1038/s41598-020-70820-6. Sci Rep. 2020. PMID: 32792639 Free PMC article.
Even though chemotherapy extends the survival of patients, there are many undesirable side effects, and most cases show resistance to TMZ. FL3 is a synthetic flavagline which displays potent anticancer activities, and is known to inhibit cell proliferation, by provo …
Even though chemotherapy extends the survival of patients, there are many undesirable side effects, and most cases show resistance to TMZ. …
The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/beta-Catenin Signaling.
Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL. Jackson DN, et al. Cancer Res. 2020 Sep 1;80(17):3519-3529. doi: 10.1158/0008-5472.CAN-20-0216. Epub 2020 Jul 14. Cancer Res. 2020. PMID: 32665357 Free PMC article.
FL3 exhibited no change in cell viability in normal intestinal epithelial cells or human matched-normal colonoids. ...These results suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of Axin1. ...
FL3 exhibited no change in cell viability in normal intestinal epithelial cells or human matched-normal colonoids. ...These results s …
Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects.
Bentayeb H, Aitamer M, Petit B, Dubanet L, Elderwish S, Désaubry L, de Gramont A, Raymond E, Olivrie A, Abraham J, Jauberteau MO, Troutaud D. Bentayeb H, et al. J Exp Clin Cancer Res. 2019 Nov 4;38(1):450. doi: 10.1186/s13046-019-1440-4. J Exp Clin Cancer Res. 2019. PMID: 31684984 Free PMC article.
METHODS: PHB expression was analyzed in 82 DLBCL biopsies and five DLBCL cell lines by immunohistochemistry (IHC) and Western blotting. Pharmacological inhibition of PHB using the synthetic flavagline FL3 was realized in vitro to gain insight PHB cellular functions. …
METHODS: PHB expression was analyzed in 82 DLBCL biopsies and five DLBCL cell lines by immunohistochemistry (IHC) and Western blotting. Phar …
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z. Yan C, et al. Autophagy. 2020 Mar;16(3):419-434. doi: 10.1080/15548627.2019.1628520. Epub 2019 Jun 16. Autophagy. 2020. PMID: 31177901 Free PMC article.
Finally, a ligand of PHB proteins that we synthesized, called FL3, was found to strongly inhibit PHB2-mediated mitophagy and to effectively block cancer cell growth and energy production at nanomolar concentrations. Thus, our findings reveal that the PHB2-PARL-PGAM5-PINK1 …
Finally, a ligand of PHB proteins that we synthesized, called FL3, was found to strongly inhibit PHB2-mediated mitophagy and to effec …
19 results