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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Krylova IN, et al. Among authors: fletterick rj. Cell. 2005 Feb 11;120(3):343-55. doi: 10.1016/j.cell.2005.01.024. Cell. 2005. PMID: 15707893 Free article.
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. Sablin EP, et al. Among authors: fletterick rj. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. doi: 10.1073/pnas.0808936105. Epub 2008 Nov 17. Proc Natl Acad Sci U S A. 2008. PMID: 19015525 Free PMC article.
Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Yumoto F, et al. Among authors: fletterick rj. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):143-8. doi: 10.1073/pnas.1117036108. Epub 2011 Dec 20. Proc Natl Acad Sci U S A. 2012. PMID: 22187462 Free PMC article.
Structure-based discovery of antagonists of nuclear receptor LRH-1.
Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Benod C, et al. Among authors: fletterick rj. J Biol Chem. 2013 Jul 5;288(27):19830-44. doi: 10.1074/jbc.M112.411686. Epub 2013 May 10. J Biol Chem. 2013. PMID: 23667258 Free PMC article.
267 results