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The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.
Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A. Göktuna SI, et al. Among authors: florin a. Cancer Res. 2016 May 1;76(9):2587-99. doi: 10.1158/0008-5472.CAN-15-1473. Epub 2016 Mar 15. Cancer Res. 2016. PMID: 26980769 Free article.
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A. Ladang A, et al. Among authors: florin a. J Exp Med. 2015 Nov 16;212(12):2057-75. doi: 10.1084/jem.20142288. Epub 2015 Nov 2. J Exp Med. 2015. PMID: 26527802 Free PMC article.
The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer.
Tang SC, Lion Q, Peulen O, Chariot P, Lavergne A, Mayer A, Fuster PA, Close P, Klein S, Florin A, Büttner R, Nemazanyy I, Shostak K, Chariot A. Tang SC, et al. Among authors: florin a. Oncogene. 2022 Jan;41(2):173-190. doi: 10.1038/s41388-021-02038-3. Epub 2021 Oct 29. Oncogene. 2022. PMID: 34716429
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P. Delaunay S, et al. Among authors: florin a. J Exp Med. 2016 Oct 17;213(11):2503-2523. doi: 10.1084/jem.20160397. Epub 2016 Oct 10. J Exp Med. 2016. PMID: 27811057 Free PMC article.
Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization.
Chen D, Nemazanyy I, Peulen O, Shostak K, Xu X, Tang SC, Wathieu C, Turchetto S, Tielens S, Nguyen L, Close P, Desmet C, Klein S, Florin A, Büttner R, Petrellis G, Dewals B, Chariot A. Chen D, et al. Among authors: florin a. EMBO J. 2022 Sep 15;41(18):e109353. doi: 10.15252/embj.2021109353. Epub 2022 Aug 3. EMBO J. 2022. PMID: 35920020 Free PMC article.
Codon-specific translation reprogramming promotes resistance to targeted therapy.
Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P. Rapino F, et al. Among authors: florin a. Nature. 2018 Jun;558(7711):605-609. doi: 10.1038/s41586-018-0243-7. Epub 2018 Jun 20. Nature. 2018. PMID: 29925953
97 results