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A new generation of potent complement inhibitors of the Compstatin family.
López de Victoria A, Gorham RD Jr, Bellows-Peterson ML, Ling J, Lo DD, Floudas CA, Morikis D. López de Victoria A, et al. Among authors: floudas ca. Chem Biol Drug Des. 2011 Jun;77(6):431-40. doi: 10.1111/j.1747-0285.2011.01111.x. Epub 2011 Apr 26. Chem Biol Drug Des. 2011. PMID: 21352502 Free PMC article.
Molecular dynamics in drug design: new generations of compstatin analogs.
Tamamis P, López de Victoria A, Gorham RD Jr, Bellows-Peterson ML, Pierou P, Floudas CA, Morikis D, Archontis G. Tamamis P, et al. Among authors: floudas ca. Chem Biol Drug Des. 2012 May;79(5):703-18. doi: 10.1111/j.1747-0285.2012.01324.x. Epub 2012 Feb 9. Chem Biol Drug Des. 2012. PMID: 22233517 Free PMC article.
Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.
Gorham RD Jr, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: floudas ca. Exp Eye Res. 2013 Nov;116:96-108. doi: 10.1016/j.exer.2013.07.023. Epub 2013 Aug 15. Exp Eye Res. 2013. PMID: 23954241 Free PMC article.
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: floudas ca. J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25494040 Free PMC article.
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a.
Halai R, Bellows-Peterson ML, Branchett W, Smadbeck J, Kieslich CA, Croker DE, Cooper MA, Morikis D, Woodruff TM, Floudas CA, Monk PN. Halai R, et al. Among authors: floudas ca. Eur J Pharmacol. 2014 Dec 15;745:176-81. doi: 10.1016/j.ejphar.2014.10.041. Epub 2014 Oct 30. Eur J Pharmacol. 2014. PMID: 25446428 Free PMC article.
92 results