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Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: flytzanis nc. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. Nat Commun. 2020. PMID: 32355221 Free PMC article.
Directed evolution of a far-red fluorescent rhodopsin.
McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. McIsaac RS, et al. Among authors: flytzanis nc. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13034-9. doi: 10.1073/pnas.1413987111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157169 Free PMC article.
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping.
Treweek JB, Chan KY, Flytzanis NC, Yang B, Deverman BE, Greenbaum A, Lignell A, Xiao C, Cai L, Ladinsky MS, Bjorkman PJ, Fowlkes CC, Gradinaru V. Treweek JB, et al. Among authors: flytzanis nc. Nat Protoc. 2015 Nov;10(11):1860-1896. doi: 10.1038/nprot.2015.122. Epub 2015 Oct 22. Nat Protoc. 2015. PMID: 26492141 Free PMC article.
Neuroscience: Fluorescent boost for voltage sensors.
Gradinaru V, Flytzanis NC. Gradinaru V, et al. Among authors: flytzanis nc. Nature. 2016 Jan 28;529(7587):469-70. doi: 10.1038/529469a. Nature. 2016. PMID: 26819038 No abstract available.
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset.
Goertsen D, Flytzanis NC, Goeden N, Chuapoco MR, Cummins A, Chen Y, Fan Y, Zhang Q, Sharma J, Duan Y, Wang L, Feng G, Chen Y, Ip NY, Pickel J, Gradinaru V. Goertsen D, et al. Among authors: flytzanis nc. Nat Neurosci. 2022 Jan;25(1):106-115. doi: 10.1038/s41593-021-00969-4. Epub 2021 Dec 9. Nat Neurosci. 2022. PMID: 34887588
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V. Chuapoco MR, et al. Among authors: flytzanis nc. Nat Nanotechnol. 2023 Oct;18(10):1241-1251. doi: 10.1038/s41565-023-01419-x. Epub 2023 Jul 10. Nat Nanotechnol. 2023. PMID: 37430038 Free PMC article.
Directed evolution of Gloeobacter violaceus rhodopsin spectral properties.
Engqvist MK, McIsaac RS, Dollinger P, Flytzanis NC, Abrams M, Schor S, Arnold FH. Engqvist MK, et al. Among authors: flytzanis nc. J Mol Biol. 2015 Jan 16;427(1):205-20. doi: 10.1016/j.jmb.2014.06.015. Epub 2014 Jun 28. J Mol Biol. 2015. PMID: 24979679 Free article.
11 results