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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 4
1983 1
1984 2
1986 1
1987 1
1988 6
1989 7
1990 3
1991 7
1992 7
1993 6
1994 6
1995 6
1996 5
1997 1
1998 1
1999 3
2000 4
2001 3
2003 7
2004 8
2005 17
2006 26
2007 27
2008 19
2009 35
2010 39
2011 49
2012 54
2013 72
2014 69
2015 88
2016 124
2017 155
2018 147
2019 198
2020 262
2021 267
2022 294
2023 292
2024 122

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2,195 results

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Page 1
Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise.
Kuramoto K, Liang H, Hong JH, He C. Kuramoto K, et al. Cell Metab. 2023 Apr 4;35(4):620-632.e5. doi: 10.1016/j.cmet.2023.01.011. Epub 2023 Feb 21. Cell Metab. 2023. PMID: 36812915 Free PMC article.
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5beta1 integrin and the downstream IKKalpha/beta-JNK1-BECN1 pathway. Thus, we demonstrate that hepatic autophagy activation drives exercise-indu …
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5bet …
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Liu X, Meng L, Li X, Li D, Liu Q, Chen Y, Li X, Bu W, Sun H. Liu X, et al. Int J Oral Sci. 2020 Dec 14;12(1):34. doi: 10.1038/s41368-020-00101-5. Int J Oral Sci. 2020. PMID: 33318468 Free PMC article.
Data from SCC-25 cells demonstrated that rapamycin and Earle's balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 degradation, while 3-methyladenine (3-MA), bafilomycin A1 (Baf A1) and chloroquine (CQ) inhibited autophagy, leading to decreased FN …
Data from SCC-25 cells demonstrated that rapamycin and Earle's balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 …
[Soft tissue tumours with FN1 (Fibronectin 1) fusion gene].
Bouvier C, Nihous H, Macagno N. Bouvier C, et al. Ann Pathol. 2022 Apr;42(3):242-248. doi: 10.1016/j.annpat.2022.01.018. Epub 2022 Feb 15. Ann Pathol. 2022. PMID: 35181149 Review. French.
Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. ...
Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or …
FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.
Chen C, Ye L, Yi J, Liu T, Li Z. Chen C, et al. Breast Cancer Res Treat. 2023 Oct;201(3):515-533. doi: 10.1007/s10549-023-07032-9. Epub 2023 Jul 17. Breast Cancer Res Treat. 2023. PMID: 37458908
In addition, inhibition of FN1 combined with the YAP1 inhibitor or SLC1A3 inhibitor can effectively inhibit tumor growth, of which inhibition of FN1 combined with the YAP1 inhibitor is more effective. CONCLUSION: Targeting the "FN1/YAP1/SLC1A3/Aspartate metab …
In addition, inhibition of FN1 combined with the YAP1 inhibitor or SLC1A3 inhibitor can effectively inhibit tumor growth, of which in …
High FN1 expression correlates with gastric cancer progression.
Li J, Chen C, Chen B, Guo T. Li J, et al. Pathol Res Pract. 2022 Nov;239:154179. doi: 10.1016/j.prp.2022.154179. Epub 2022 Oct 18. Pathol Res Pract. 2022. PMID: 36274380
In tumor tissues, FN1 is mostly distributed in the stroma. High E-FN1 expression was associated with a decreased overall survival (OS), while S-FN1 expression did not. ...CONCLUSIONS: High E-FN1 expression predicted poor OS, while S-FN1 is assoc …
In tumor tissues, FN1 is mostly distributed in the stroma. High E-FN1 expression was associated with a decreased overall survi …
FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer.
Zhang XX, Luo JH, Wu LQ. Zhang XX, et al. Front Genet. 2022 Aug 12;13:913659. doi: 10.3389/fgene.2022.913659. eCollection 2022. Front Genet. 2022. PMID: 36035176 Free PMC article.
Results: FN1 was upregulated in BRCA tissues compared with normal tissues. ...Several drugs such as telmisartan, malotilate, and seocalcitol may have therapeutic effects in BRCA patients with high FN1 expression. Conclusion: FN1 might serve as a novel prognos …
Results: FN1 was upregulated in BRCA tissues compared with normal tissues. ...Several drugs such as telmisartan, malotilate, and seoc …
FN1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers.
Wang H, Zhang J, Li H, Yu H, Chen S, Liu S, Zhang C, He Y. Wang H, et al. Front Oncol. 2022 Aug 23;12:918719. doi: 10.3389/fonc.2022.918719. eCollection 2022. Front Oncol. 2022. PMID: 36081567 Free PMC article.
We discovered that tumor tissue expresses FN1 at a higher level than neighboring tissue, and those genes coexpressed with FN1 have a poor prognosis. ...Using immunohistochemistry, we discovered that FN1 expression was tightly connected to M2 macrophages. It c …
We discovered that tumor tissue expresses FN1 at a higher level than neighboring tissue, and those genes coexpressed with FN1 …
Unravelling the role of immune cells and FN1 in the recurrence and therapeutic process of skull base chordoma.
Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z, Wang K. Huo X, et al. Clin Transl Med. 2023 Oct;13(10):e1429. doi: 10.1002/ctm2.1429. Clin Transl Med. 2023. PMID: 37784253 Free PMC article.
Finally, FN1 enhanced the invasion and proliferation of chordomas in vivo and in vitro. CONCLUSION: Our comprehensive picture of the microenvironment of primary and recurrent chordomas provides deep insights into the mechanisms of chordoma recurrence. FN1 is an impo …
Finally, FN1 enhanced the invasion and proliferation of chordomas in vivo and in vitro. CONCLUSION: Our comprehensive picture of the …
High FN1 expression is associated with poor survival in esophageal squamous cell carcinoma.
Ma J, Chen S, Su M, Wang W. Ma J, et al. Medicine (Baltimore). 2023 Apr 7;102(14):e33388. doi: 10.1097/MD.0000000000033388. Medicine (Baltimore). 2023. PMID: 37026938 Free PMC article.
IHC results showed that FN1 protein was expressed in both tumor cells and stroma. High expression of FN1 mRNA and FN1 protein in ESCC tumor tissues was significantly correlated with the depth of tumor invasion, lymph node metastasis and clinical stage of the …
IHC results showed that FN1 protein was expressed in both tumor cells and stroma. High expression of FN1 mRNA and FN1 p …
FN1 Promotes Thyroid Carcinoma Cell Proliferation and Metastasis by Activating the NF-kappab Pathway.
Chen C, Shen Z. Chen C, et al. Protein Pept Lett. 2023;30(1):54-64. doi: 10.2174/0929866530666221019162943. Protein Pept Lett. 2023. PMID: 36278453
Functional experiments showed that overexpression of FN1 in the MDA-T85 cell line promoted growth, migration and aggressiveness; knockdown of FN1 in MDA-T41 cells inhibited these malignant behaviors. ...FN1 will be a promising biomarker of THCA and may become …
Functional experiments showed that overexpression of FN1 in the MDA-T85 cell line promoted growth, migration and aggressiveness; knoc …
2,195 results