Fowler S - Search Results

1

PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.

Ozbey AC, Fowler S, Leys K, Annaert P, Umehara K, Parrott N. Ozbey AC, et al. Among authors: fowler s. Drug Metab Dispos. 2023 Oct 25:DMD-AR-2023-001487. doi: 10.1124/dmd.123.001487. Online ahead of print. Drug Metab Dispos. 2023. PMID: 37879848 Free article.

2

Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

Heikkinen AT, Friedlein A, Lamerz J, Jakob P, Cutler P, Fowler S, Williamson T, Tolando R, Lave T, Parrott N. Heikkinen AT, et al. Among authors: fowler s. Pharm Res. 2012 Jul;29(7):1832-42. doi: 10.1007/s11095-012-0707-7. Epub 2012 Feb 22. Pharm Res. 2012. PMID: 22354837

3

In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver.

Heikkinen AT, Fowler S, Gray L, Li J, Peng Y, Yadava P, Railkar A, Parrott N. Heikkinen AT, et al. Among authors: fowler s. Mol Pharm. 2013 Apr 1;10(4):1388-99. doi: 10.1021/mp300692k. Epub 2013 Mar 13. Mol Pharm. 2013. PMID: 23438212

4

Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.

Boetsch C, Parrott N, Fowler S, Poirier A, Hainzl D, Banken L, Martin-Facklam M, Hofmann C. Boetsch C, et al. Among authors: fowler s. Clin Pharmacokinet. 2016 Feb;55(2):237-47. doi: 10.1007/s40262-015-0312-0. Clin Pharmacokinet. 2016. PMID: 26341813 Clinical Trial.

5

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

Fowler S, Guerini E, Qiu N, Cleary Y, Parrott N, Greig G, Mallalieu NL. Fowler S, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):164-173. doi: 10.1124/jpet.116.237214. Epub 2016 Nov 7. J Pharmacol Exp Ther. 2017. PMID: 27821711 Clinical Trial.

6

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ. Kratochwil NA, et al. Among authors: fowler s. AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3. AAPS J. 2017. PMID: 28050713 Free article.

7

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L. Fowler S, et al. Curr Pharmacol Rep. 2017;3(1):36-49. doi: 10.1007/s40495-017-0082-5. Epub 2017 Feb 1. Curr Pharmacol Rep. 2017. PMID: 28261547 Free PMC article. Review.

8

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

Cleary Y, Gertz M, Morcos PN, Yu L, Youdim K, Phipps A, Fowler S, Parrott N. Cleary Y, et al. Among authors: fowler s. Clin Pharmacol Ther. 2018 Sep;104(3):505-514. doi: 10.1002/cpt.956. Epub 2017 Dec 27. Clin Pharmacol Ther. 2018. PMID: 29226313

9

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Kratochwil NA, Triyatni M, Mueller MB, Klammers F, Leonard B, Turley D, Schmaler J, Ekiciler A, Molitor B, Walter I, Gonsard PA, Tournillac CA, Durrwell A, Marschmann M, Jones R, Ullah M, Boess F, Ottaviani G, Jin Y, Parrott NJ, Fowler S. Kratochwil NA, et al. Among authors: fowler s. J Pharmacol Exp Ther. 2018 May;365(2):237-248. doi: 10.1124/jpet.117.245712. Epub 2018 Feb 16. J Pharmacol Exp Ther. 2018. PMID: 29453199

10

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.

Badée J, Fowler S, de Wildt SN, Collier AC, Schmidt S, Parrott N. Badée J, et al. Among authors: fowler s. Clin Pharmacokinet. 2019 Feb;58(2):189-211. doi: 10.1007/s40262-018-0681-2. Clin Pharmacokinet. 2019. PMID: 29862468 Review.

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