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1993 1
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Page 1
FOXP2-Related Speech and Language Disorder.
Morgan A, Fisher SE, Scheffer I, Hildebrand M. Morgan A, et al. 2016 Jun 23 [updated 2023 Jan 26]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2016 Jun 23 [updated 2023 Jan 26]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 27336128 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: FOXP2-related speech and language disorder (FOXP2-SLD) is caused by heterozygous FOXP2 pathogenic variants (including whole- or partial-gene deletions). ...Autistic features or a diagnosis of autism spectrum disorder have been report …
CLINICAL CHARACTERISTICS: FOXP2-related speech and language disorder (FOXP2-SLD) is caused by heterozygous FOXP2 pathog …
FOXP2.
Nudel R, Newbury DF. Nudel R, et al. Wiley Interdiscip Rev Cogn Sci. 2013 Sep;4(5):547-560. doi: 10.1002/wcs.1247. Epub 2013 Aug 13. Wiley Interdiscip Rev Cogn Sci. 2013. PMID: 24765219 Free PMC article. Review.
The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. ...We then discuss recent investigations into the molecular function of the FOXP2 gene, including functional and gene expression studies. We conclude this rev …
The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. ...We then discuss recent …
FOXP2 confers oncogenic effects in prostate cancer.
Zhu X, Chen C, Wei D, Xu Y, Liang S, Jia W, Li J, Qu Y, Zhai J, Zhang Y, Wu P, Hao Q, Zhang L, Zhang W, Yang X, Pan L, Qi R, Li Y, Wang F, Yi R, Yang Z, Wang J, Zhao Y. Zhu X, et al. Elife. 2023 Sep 5;12:e81258. doi: 10.7554/eLife.81258. Elife. 2023. PMID: 37668356 Free PMC article.
Overexpression of FOXP2 aberrantly activates oncogenic MET signaling and inhibition of MET signaling effectively reverts the FOXP2-induced oncogenic phenotype. CUT&Tag assay identified FOXP2-binding sites located in MET and its associated gene HGF. Additi …
Overexpression of FOXP2 aberrantly activates oncogenic MET signaling and inhibition of MET signaling effectively reverts the FOXP2 …
Molecular networks of the FOXP2 transcription factor in the brain.
den Hoed J, Devaraju K, Fisher SE. den Hoed J, et al. EMBO Rep. 2021 Aug 4;22(8):e52803. doi: 10.15252/embr.202152803. Epub 2021 Jul 14. EMBO Rep. 2021. PMID: 34260143 Free PMC article. Review.
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discus …
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to …
FoxP2 in songbirds.
Wohlgemuth S, Adam I, Scharff C. Wohlgemuth S, et al. Curr Opin Neurobiol. 2014 Oct;28:86-93. doi: 10.1016/j.conb.2014.06.009. Epub 2014 Jul 19. Curr Opin Neurobiol. 2014. PMID: 25048597
Humans with mutations in the transcription factor FOXP2 display a severe speech disorder. Songbirds are a powerful model system to study FoxP2. ...During the past five years significant progress has been made moving from a descriptive to a more mechanistic understan …
Humans with mutations in the transcription factor FOXP2 display a severe speech disorder. Songbirds are a powerful model system to st …
FoxP2 brainstem neurons project to sodium appetite regulatory sites.
Shin JW, Geerling JC, Stein MK, Miller RL, Loewy AD. Shin JW, et al. J Chem Neuroanat. 2011 Sep;42(1):1-23. doi: 10.1016/j.jchemneu.2011.05.003. Epub 2011 May 13. J Chem Neuroanat. 2011. PMID: 21605659 Free PMC article. Review.
The pre-LC outputs were first analyzed using an anterograde axonal tracer--Phaseolus vulgaris leucoagglutinin (PHAL) to construct a brain map. Next, we examined whether the FoxP2 immunoreactive (FoxP2+) neurons of the pre-LC contribute to these projections using a r …
The pre-LC outputs were first analyzed using an anterograde axonal tracer--Phaseolus vulgaris leucoagglutinin (PHAL) to construct a brain ma …
FOXP2 as a molecular window into speech and language.
Fisher SE, Scharff C. Fisher SE, et al. Trends Genet. 2009 Apr;25(4):166-77. doi: 10.1016/j.tig.2009.03.002. Epub 2009 Mar 21. Trends Genet. 2009. PMID: 19304338 Review.
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits. ...Converging data indicate that Foxp2 is important for modulating the plasticity of relevant neural circuits. ...
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and lin …
FOXP2 and the neuroanatomy of speech and language.
Vargha-Khadem F, Gadian DG, Copp A, Mishkin M. Vargha-Khadem F, et al. Nat Rev Neurosci. 2005 Feb;6(2):131-8. doi: 10.1038/nrn1605. Nat Rev Neurosci. 2005. PMID: 15685218 Review.
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into the genetic basis of these remarkable faculties been found. The discovery of a mutation in FOXP2 in a family with a speech and languag …
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into t …
What can mice tell us about Foxp2 function?
French CA, Fisher SE. French CA, et al. Curr Opin Neurobiol. 2014 Oct;28:72-9. doi: 10.1016/j.conb.2014.07.003. Epub 2014 Jul 19. Curr Opin Neurobiol. 2014. PMID: 25048596 Review.
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigating the relevant neural pathways. ...Here we describe how investigations of mice that carry disruptions of Foxp2 provide insights at m …
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigati …
The Language Development Via FOXP2 in Autism Spectrum Disorder: A Review.
Chen P, Li Z, Li Y, Ahmad SS, Kamal MA, Huo X. Chen P, et al. Curr Pharm Des. 2020;26(37):4789-4795. doi: 10.2174/1381612826666200909141108. Curr Pharm Des. 2020. PMID: 32912122 Review.
In any case, changes in FOXP2 lead to a speech/language issue portrayed by childhood apraxia of speech. ...CONCLUSION: The purpose of this study was to explore the role of FOXP2 in language disorder and its management for children's language and communication develo …
In any case, changes in FOXP2 lead to a speech/language issue portrayed by childhood apraxia of speech. ...CONCLUSION: The purpose of …
797 results