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Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Thompson AM, et al. Among authors: franzblau sg. J Med Chem. 2016 Mar 24;59(6):2530-50. doi: 10.1021/acs.jmedchem.5b01699. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26901446 Free article.
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Marshall AJ, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Franzblau SG, Wan B, Wang Y, Ma Z, Cooper CB, Denny WA. Thompson AM, et al. Among authors: franzblau sg. J Med Chem. 2017 May 25;60(10):4212-4233. doi: 10.1021/acs.jmedchem.7b00034. Epub 2017 May 11. J Med Chem. 2017. PMID: 28459575 Free PMC article.
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. Lauinger IL, et al. Among authors: franzblau sg. J Nat Prod. 2013 Jun 28;76(6):1064-70. doi: 10.1021/np400083k. Epub 2013 Jun 19. J Nat Prod. 2013. PMID: 23806111 Free PMC article.
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Marshall AJ, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA. Thompson AM, et al. Among authors: franzblau sg. J Med Chem. 2018 Mar 22;61(6):2329-2352. doi: 10.1021/acs.jmedchem.7b01581. Epub 2018 Mar 6. J Med Chem. 2018. PMID: 29461823 Free PMC article.
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Thompson AM, O'Connor PD, Marshall AJ, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA. Thompson AM, et al. Among authors: franzblau sg. Eur J Med Chem. 2021 Jan 1;209:112914. doi: 10.1016/j.ejmech.2020.112914. Epub 2020 Oct 10. Eur J Med Chem. 2021. PMID: 33268145
Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility.
Thompson AM, O'Connor PD, Yardley V, Maes L, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA. Thompson AM, et al. Among authors: franzblau sg. ACS Med Chem Lett. 2021 Jan 21;12(2):275-281. doi: 10.1021/acsmedchemlett.0c00649. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603975 Free PMC article.
347 results