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Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid.
Zamboni R, Belley M, Champion E, Charette L, DeHaven R, Frenette R, Gauthier JY, Jones TR, Leger S, Masson P, et al. Zamboni R, et al. Among authors: frenette r. J Med Chem. 1992 Oct 16;35(21):3832-44. doi: 10.1021/jm00099a011. J Med Chem. 1992. PMID: 1331447
L-648,051: an aerosol active leukotriene D4 receptor antagonist.
Jones TR, Guindon Y, Champion E, Charette L, DeHaven RN, Denis D, Ethier D, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Jones TR, et al. Among authors: frenette r. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:1012-7. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2823551 No abstract available.
Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4.
Young RN, Jones TR, Atkinson JG, Bélanger P, Champion E, Denis D, DeHaven RN, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Young RN, et al. Among authors: frenette r. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:544-8. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2959111 No abstract available.
L-649,923, sodium (beta S*, gamma R*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)- gamma-hydroxy-beta-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist.
Jones TR, Young R, Champion E, Charette L, Denis D, Ford-Hutchinson AW, Frenette R, Gauthier JY, Guindon Y, Kakushima M, et al. Jones TR, et al. Among authors: frenette r. Can J Physiol Pharmacol. 1986 Aug;64(8):1068-75. doi: 10.1139/y86-183. Can J Physiol Pharmacol. 1986. PMID: 3024787
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
Young RN, Bélanger P, Champion E, DeHaven RN, Denis D, Ford-Hutchinson AW, Fortin R, Frenette R, Gauthier JY, Gillard J, et al. Young RN, et al. Among authors: frenette r. J Med Chem. 1986 Sep;29(9):1573-6. doi: 10.1021/jm00159a003. J Med Chem. 1986. PMID: 3746809 No abstract available.
Comparison of inhibition of ovalbumin-induced bronchoconstriction in guinea pigs and in vitro inhibition of tumor necrosis factor-alpha formation with phosphodiesterase 4 (PDE4) selective inhibitors.
Muise ES, Chute IC, Claveau D, Masson P, Boulet L, Tkalec L, Pon DJ, Girard Y, Frenette R, Mancini JA. Muise ES, et al. Among authors: frenette r. Biochem Pharmacol. 2002 Apr 15;63(8):1527-35. doi: 10.1016/s0006-2952(02)00903-6. Biochem Pharmacol. 2002. PMID: 11996895
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