Freudenthal BD - Search Results

1

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.

Whitaker AM, Smith MR, Schaich MA, Freudenthal BD. Whitaker AM, et al. Among authors: freudenthal bd. Nucleic Acids Res. 2017 Jun 20;45(11):6934-6944. doi: 10.1093/nar/gkx293. Nucleic Acids Res. 2017. PMID: 28449123 Free PMC article.

2

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.

Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT. Freudenthal BD, et al. Nat Struct Mol Biol. 2010 Apr;17(4):479-84. doi: 10.1038/nsmb.1776. Epub 2010 Mar 21. Nat Struct Mol Biol. 2010. PMID: 20305653 Free PMC article.

3

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.

Freudenthal BD, Beard WA, Wilson SH. Freudenthal BD, et al. Nucleic Acids Res. 2013 Feb 1;41(3):1848-58. doi: 10.1093/nar/gks1276. Epub 2012 Dec 24. Nucleic Acids Res. 2013. PMID: 23267011 Free PMC article.

4

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.

Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Freudenthal BD, et al. Nature. 2015 Jan 29;517(7536):635-9. doi: 10.1038/nature13886. Epub 2014 Nov 17. Nature. 2015. PMID: 25409153 Free PMC article.

5

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening.

Kim T, Freudenthal BD, Beard WA, Wilson SH, Schlick T. Kim T, et al. Among authors: freudenthal bd. Nucleic Acids Res. 2016 May 19;44(9):4409-24. doi: 10.1093/nar/gkw174. Epub 2016 Mar 31. Nucleic Acids Res. 2016. PMID: 27034465 Free PMC article.

6

Revealing the role of the product metal in DNA polymerase β catalysis.

Perera L, Freudenthal BD, Beard WA, Pedersen LG, Wilson SH. Perera L, et al. Among authors: freudenthal bd. Nucleic Acids Res. 2017 Mar 17;45(5):2736-2745. doi: 10.1093/nar/gkw1363. Nucleic Acids Res. 2017. PMID: 28108654 Free PMC article.

7

Base excision repair of oxidative DNA damage: from mechanism to disease.

Whitaker AM, Schaich MA, Smith MR, Flynn TS, Freudenthal BD. Whitaker AM, et al. Among authors: freudenthal bd. Front Biosci (Landmark Ed). 2017 Mar 1;22(9):1493-1522. doi: 10.2741/4555. Front Biosci (Landmark Ed). 2017. PMID: 28199214 Free PMC article. Review.

8

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction.

Shock DD, Freudenthal BD, Beard WA, Wilson SH. Shock DD, et al. Among authors: freudenthal bd. Nat Chem Biol. 2017 Oct;13(10):1074-1080. doi: 10.1038/nchembio.2450. Epub 2017 Jul 31. Nat Chem Biol. 2017. PMID: 28759020 Free PMC article.

9

Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.

Schaich MA, Smith MR, Cloud AS, Holloran SM, Freudenthal BD. Schaich MA, et al. Among authors: freudenthal bd. Chem Res Toxicol. 2017 Nov 20;30(11):1993-2001. doi: 10.1021/acs.chemrestox.7b00173. Epub 2017 Sep 1. Chem Res Toxicol. 2017. PMID: 28862449 Free PMC article.

10

Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors.

Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J. Bastola P, et al. Among authors: freudenthal bd. Cell Death Discov. 2017 Nov 6;3:17065. doi: 10.1038/cddiscovery.2017.65. eCollection 2017. Cell Death Discov. 2017. PMID: 29367883 Free PMC article.

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