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Quantitative systems pharmacology model-based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3-kinase inhibitors.
Gadkar K, Friedrich C, Hurez V, Ruiz ML, Dickmann L, Kumar Jolly M, Schutt L, Jin J, Ware JA, Ramanujan S. Gadkar K, et al. CPT Pharmacometrics Syst Pharmacol. 2022 May;11(5):616-627. doi: 10.1002/psp4.12749. Epub 2021 Dec 13. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 34850607 Free PMC article.
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
Ramakrishnan V, Friedrich C, Witt C, Sheehan R, Pryor M, Atwal JK, Wildsmith K, Kudrycki K, Lee SH, Mazer N, Hofmann C, Fuji RN, Jin JY, Ramanujan S, Dolton M, Quartino A. Ramakrishnan V, et al. CPT Pharmacometrics Syst Pharmacol. 2023 Jan;12(1):62-73. doi: 10.1002/psp4.12876. Epub 2022 Nov 6. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36281062 Free PMC article.
A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.
Ming JE, Abrams RE, Bartlett DW, Tao M, Nguyen T, Surks H, Kudrycki K, Kadambi A, Friedrich CM, Djebli N, Goebel B, Koszycki A, Varshnaya M, Elassal J, Banerjee P, Sasiela WJ, Reed MJ, Barrett JS, Azer K. Ming JE, et al. Among authors: friedrich cm. Gene Regul Syst Bio. 2017 Jun 22;11:1177625017710941. doi: 10.1177/1177625017710941. eCollection 2017. Gene Regul Syst Bio. 2017. PMID: 28804243 Free PMC article.
In silico prediction of clinical efficacy.
Michelson S, Sehgal A, Friedrich C. Michelson S, et al. Curr Opin Biotechnol. 2006 Dec;17(6):666-70. doi: 10.1016/j.copbio.2006.09.004. Epub 2006 Oct 12. Curr Opin Biotechnol. 2006. PMID: 17046236 Review.
69 results