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Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Engers DW, et al. Among authors: frist ay. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. doi: 10.1016/j.bmcl.2013.03.113. Epub 2013 Apr 11. Bioorg Med Chem Lett. 2013. PMID: 23639540 Free PMC article.
Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.
Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58. doi: 10.1124/jpet.114.216903. Epub 2014 Sep 30. J Pharmacol Exp Ther. 2014. PMID: 25271257 Free PMC article.
Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor.
Engers DW, Frist AY, Lindsley CW, Hong CH, Hopkins CR. Engers DW, et al. Among authors: frist ay. 2013 Apr 12 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2013 Apr 12 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 25506972 Free Books & Documents. Review.
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