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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D. Zyryanova AF, et al. Among authors: fromont c. Science. 2018 Mar 30;359(6383):1533-1536. doi: 10.1126/science.aar5129. Science. 2018. PMID: 29599245 Free PMC article.
Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.
Baker JG, Gardiner SM, Woolard J, Fromont C, Jadhav GP, Mistry SN, Thompson KSJ, Kellam B, Hill SJ, Fischer PM. Baker JG, et al. Among authors: fromont c. FASEB J. 2017 Jul;31(7):3150-3166. doi: 10.1096/fj.201601305R. Epub 2017 Apr 11. FASEB J. 2017. PMID: 28400472 Free PMC article.
They potentially offer a truly cardioselective beta-blocker therapy for the large number of patients with heart and respiratory or peripheral vascular comorbidities.-Baker, J. G., Gardiner, S. M., Woolard, J., Fromont, C., Jadhav, G. P., Mistry, S. N., Thompson, K. …
They potentially offer a truly cardioselective beta-blocker therapy for the large number of patients with heart and respiratory or periphera …
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.
Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach.
Qin C, Chu Y, Feng W, Fromont C, He S, Ali J, Lee JB, Zgair A, Berton M, Bettonte S, Liu R, Yang L, Monmaturapoj T, Medrano-Padial C, Ugalde AAR, Vetrugno D, Ee SY, Sheriston C, Wu Y, Stocks MJ, Fischer PM, Gershkovich P. Qin C, et al. Among authors: fromont c. J Control Release. 2021 Jan 10;329:1077-1089. doi: 10.1016/j.jconrel.2020.10.036. Epub 2020 Oct 20. J Control Release. 2021. PMID: 33091528
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
Potter A, Oldfield V, Nunns C, Fromont C, Ray S, Northfield CJ, Bryant CJ, Scrace SF, Robinson D, Matossova N, Baker L, Dokurno P, Surgenor AE, Davis B, Richardson CM, Murray JB, Moore JD. Potter A, et al. Among authors: fromont c. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6483-8. doi: 10.1016/j.bmcl.2010.09.063. Epub 2010 Sep 17. Bioorg Med Chem Lett. 2010. PMID: 20932746
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
Brough PA, Barril X, Borgognoni J, Chene P, Davies NG, Davis B, Drysdale MJ, Dymock B, Eccles SA, Garcia-Echeverria C, Fromont C, Hayes A, Hubbard RE, Jordan AM, Jensen MR, Massey A, Merrett A, Padfield A, Parsons R, Radimerski T, Raynaud FI, Robertson A, Roughley SD, Schoepfer J, Simmonite H, Sharp SY, Surgenor A, Valenti M, Walls S, Webb P, Wood M, Workman P, Wright L. Brough PA, et al. Among authors: fromont c. J Med Chem. 2009 Aug 13;52(15):4794-809. doi: 10.1021/jm900357y. J Med Chem. 2009. PMID: 19610616
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE. Wright L, et al. Among authors: fromont c. Chem Biol. 2004 Jun;11(6):775-85. doi: 10.1016/j.chembiol.2004.03.033. Chem Biol. 2004. PMID: 15217611
28 results