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Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase.
Chem Commun (Camb). 2013 Apr 21;49(31):3197-9. doi: 10.1039/c3cc41191e. Epub 2013 Mar 12.
Chem Commun (Camb). 2013.
PMID: 23482955
Free PMC article.
Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors.
Garner AL, Fullagar JL, Day JA, Cohen SM, Janda KD.
Garner AL, et al. Among authors: fullagar jl.
J Am Chem Soc. 2013 Jul 10;135(27):10014-7. doi: 10.1021/ja404180x. Epub 2013 Jun 28.
J Am Chem Soc. 2013.
PMID: 23808771
Free PMC article.
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Jacobsen JA, Fullagar JL, Miller MT, Cohen SM.
Jacobsen JA, et al. Among authors: fullagar jl.
J Med Chem. 2011 Jan 27;54(2):591-602. doi: 10.1021/jm101266s. Epub 2010 Dec 28.
J Med Chem. 2011.
PMID: 21189019
Free PMC article.
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3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
Garner AL, Struss AK, Fullagar JL, Agrawal A, Moreno AY, Cohen SM, Janda KD.
Garner AL, et al. Among authors: fullagar jl.
ACS Med Chem Lett. 2012 Aug 9;3(8):668-672. doi: 10.1021/ml300128f. Epub 2012 Jun 19.
ACS Med Chem Lett. 2012.
PMID: 23181168
Free PMC article.
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Probing chelation motifs in HIV integrase inhibitors.
Agrawal A, DeSoto J, Fullagar JL, Maddali K, Rostami S, Richman DD, Pommier Y, Cohen SM.
Agrawal A, et al. Among authors: fullagar jl.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2251-6. doi: 10.1073/pnas.1112389109. Epub 2012 Jan 27.
Proc Natl Acad Sci U S A. 2012.
PMID: 22308350
Free PMC article.
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