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FXYD5: Na(+)/K(+)-ATPase Regulator in Health and Disease.
Lubarski Gotliv I. Lubarski Gotliv I. Front Cell Dev Biol. 2016 Mar 30;4:26. doi: 10.3389/fcell.2016.00026. eCollection 2016. Front Cell Dev Biol. 2016. PMID: 27066483 Free PMC article. Review.
In this review, current knowledge on FXYD5 is discussed, including experimental data on the functional effects of FXYD5 on the Na(+)/K(+)-ATPase. FXYD5 modulates cellular junctions, influences chemokine production, and affects cell adhesion. ...
In this review, current knowledge on FXYD5 is discussed, including experimental data on the functional effects of FXYD5 on the …
FXYD5 promotes sorafenib resistance through the Akt/mTOR signaling pathway in hepatocellular carcinoma.
Tan XP, Xiong BH, Zhang YX, Wang SL, Zuo Q, Li J. Tan XP, et al. Eur J Pharmacol. 2022 Sep 15;931:175186. doi: 10.1016/j.ejphar.2022.175186. Epub 2022 Aug 14. Eur J Pharmacol. 2022. PMID: 35977595 Free article.
Remarkably, downregulation of FXYD5 expression in Huh7/sora cells reversed their resistance to sorafenib. ...In conclusion, this study showed that the activation of the FXYD5/Akt/mTOR signaling axis plays key role in the resistance of HCC cells to sorafenib, and …
Remarkably, downregulation of FXYD5 expression in Huh7/sora cells reversed their resistance to sorafenib. ...In conclusion, this stud …
FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.
Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA. Brazee PL, et al. Front Immunol. 2017 Jun 1;8:623. doi: 10.3389/fimmu.2017.00623. eCollection 2017. Front Immunol. 2017. PMID: 28620381 Free PMC article.
The aim of this study was to determine whether FXYD5 contributes to the lung inflammation and injury. Exposure of alveolar epithelial cells (AEC) to LPS increased FXYD5 levels at the plasma membrane, and FXYD5 silencing prevented both the activation of NF-kap …
The aim of this study was to determine whether FXYD5 contributes to the lung inflammation and injury. Exposure of alveolar epithelial …
miR-1180 Targets FXYD5 to Regulate Pancreatic Cancer Cells Migration and Invasion.
Xie H, Li J, Lu M, Zhang R, Mao H. Xie H, et al. Mol Biotechnol. 2023 Dec 28. doi: 10.1007/s12033-023-00923-8. Online ahead of print. Mol Biotechnol. 2023. PMID: 38155284
FXYD5 expression was increased in pancreatic cancer tissue samples than in adjacent normal tissue samples (P < 0.01), and FXYD5 expression exhibited a positive correlation with the migratory and invasive ability of pancreatic cancer cells. miR-1180 targeted FX …
FXYD5 expression was increased in pancreatic cancer tissue samples than in adjacent normal tissue samples (P < 0.01), and FXYD5 …
Fxyd5 activates the NF-kappaB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation.
Song L, Li X, Sun Q, Zhao Y. Song L, et al. Mol Med Rep. 2022 Apr;25(4):134. doi: 10.3892/mmr.2022.12650. Epub 2022 Feb 22. Mol Med Rep. 2022. PMID: 35191523 Free PMC article.
The present study aimed to investigate the role of Fxyd5 in OA. Murine ATDC5 chondrocytes were transfected with short hairpin RNAs specifically targeting Fxyd5 to silence its expression. ...Finally, BA reversed the protective effect of Fxyd5 silencing on LPS …
The present study aimed to investigate the role of Fxyd5 in OA. Murine ATDC5 chondrocytes were transfected with short hairpin RNAs sp …
FXYD5/Dysadherin, a Biomarker of Endometrial Cancer Myometrial Invasion and Aggressiveness: Its Relationship With TGF-beta1 and NF-kappaB Pathways.
Besso MJ, Rosso M, Lapyckyj L, Moiola CP, Matos ML, Mercogliano MF, Schillaci R, Reventos J, Colas E, Gil-Moreno A, Wernicke A, Orti R, Vazquez-Levin MH. Besso MJ, et al. Front Oncol. 2019 Dec 6;9:1306. doi: 10.3389/fonc.2019.01306. eCollection 2019. Front Oncol. 2019. PMID: 31867269 Free PMC article.
FXYD5/Dys impact on E-cadherin expression and cell behavior was assessed in EC Hec1a cells treated with transforming growth factor (TGF)-beta1, stably transfected with ETV5, and transiently transfected with FXYD5/Dys small interfering RNA (siRNA) or pcDNA3-FXYD5 …
FXYD5/Dys impact on E-cadherin expression and cell behavior was assessed in EC Hec1a cells treated with transforming growth factor (T …
FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells.
Lubarski-Gotliv I, Asher C, Dada LA, Garty H. Lubarski-Gotliv I, et al. J Biol Chem. 2016 May 20;291(21):11072-82. doi: 10.1074/jbc.M115.699041. Epub 2016 Mar 22. J Biol Chem. 2016. PMID: 27006401 Free PMC article.
As other FXYD proteins, FXYD5 specifically interacts with the Na,K-ATPase and alters its kinetics by increasing Vmax However, unlike other family members FXYD5 appears to have additional functions, which cannot be readily explained by modulation of transport kinetic …
As other FXYD proteins, FXYD5 specifically interacts with the Na,K-ATPase and alters its kinetics by increasing Vmax However, unlike …
Low expression of FXYD5 reverses the cisplatin resistance of epithelial ovarian cancer cells.
Liu YK, Jia YJ, Liu SH, Shi HJ, Ma J. Liu YK, et al. Histol Histopathol. 2021 May;36(5):535-545. doi: 10.14670/HH-18-310. Epub 2021 Feb 11. Histol Histopathol. 2021. PMID: 33570156
RESULTS: Compared with the sensitive parental cells, the A2780-CisR and SKOV3-CisR cells had increased IC50 and FXYD5 expression. FXYD5 siRNA reduced the IC50 value of cisplatin in the A2780-CisR and SKOV3-CisR cells and decreased the expression of ABCG2 (BCRP) and …
RESULTS: Compared with the sensitive parental cells, the A2780-CisR and SKOV3-CisR cells had increased IC50 and FXYD5 expression. …
A FXYD5/TGF-beta/SMAD positive feedback loop drives epithelial-to-mesenchymal transition and promotes tumor growth and metastasis in ovarian cancer.
Bai Y, Li LD, Li J, Chen RF, Yu HL, Sun HF, Wang JY, Lu X. Bai Y, et al. Int J Oncol. 2020 Jan;56(1):301-314. doi: 10.3892/ijo.2019.4911. Epub 2019 Nov 13. Int J Oncol. 2020. PMID: 31746425
The TGF-beta-activated SMAD3/SMAD4 complex was in turn directly recruited to the FXYD5 promoter region, interacted with specific SMAD-binding elements, and then promoted FXYD5 transcription. In brief, FXYD5 positively regulated TGF-beta/SMADs signaling activi …
The TGF-beta-activated SMAD3/SMAD4 complex was in turn directly recruited to the FXYD5 promoter region, interacted with specific SMAD …
Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute Pancreatitis.
Fang Z, Li J, Cao F, Li F. Fang Z, et al. Biomolecules. 2022 Dec 30;13(1):78. doi: 10.3390/biom13010078. Biomolecules. 2022. PMID: 36671463 Free PMC article.
The present study also investigated cell-to-cell communication networks using the CellChat package, and AP-specific gene signatures (Clic1, Sat1, Serpina3n, Atf3, Lcn2, Osmr, Ccl9, Hspb1, Anxa2, Krt8, Cd44, Cd9, Hsp90aa1, Tmsb10, Hmox1, Fxyd5, Plin2, Pnp) were identified t …
The present study also investigated cell-to-cell communication networks using the CellChat package, and AP-specific gene signatures (Clic1, …
101 results