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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 2
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2002 3
2003 2
2004 8
2005 7
2006 6
2007 5
2008 6
2009 12
2010 7
2011 17
2012 10
2013 13
2014 17
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2023 25
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262 results

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Page 1
Construction of Fzd6(Q152E )mice through CRISPR/Cas9 technology and their reproduction and identification.
Yan X, Yang J, Xiao L, Gao J, Xu G, Wang L, Qi Y, Song G. Yan X, et al. Mol Biol Rep. 2022 Oct;49(10):9575-9584. doi: 10.1007/s11033-022-07848-6. Epub 2022 Aug 18. Mol Biol Rep. 2022. PMID: 35980530
BACKGROUND: The CRISPR/Cas9 system is widely used for genome editing in human, rat and mouse cells. In this study, we established Fzd6 mutant mice using CRISPR/Cas9 technology, and obtained Fzd6 homozygous mutant (Fzd6(Q152E)) mice through breeding. Fzd6 …
BACKGROUND: The CRISPR/Cas9 system is widely used for genome editing in human, rat and mouse cells. In this study, we established Fzd6 …
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage.
Corda G, Sala A. Corda G, et al. Oncogenesis. 2017 Jul 24;6(7):e364. doi: 10.1038/oncsis.2017.69. Oncogenesis. 2017. PMID: 28737757 Free PMC article. Review.
In this review, we discuss the emerging role of the wnt non-canonical pathway regulated by frizzled receptor 6 (Fzd6) in the pathogenesis of different types of human malignancies. The function played by Fzd6 in the physiology of normal and cancer cells has been high …
In this review, we discuss the emerging role of the wnt non-canonical pathway regulated by frizzled receptor 6 (Fzd6) in the pathogen …
FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial-Mesenchymal Transition.
Dong B, Simonson L, Vold S, Oldham E, Barten L, Ahmad N, Chang H. Dong B, et al. J Invest Dermatol. 2023 Apr;143(4):621-629.e6. doi: 10.1016/j.jid.2022.09.658. Epub 2022 Nov 9. J Invest Dermatol. 2023. PMID: 36368445 Free PMC article.
FZD6 is a key gene that controls tissue polarity during development. ...Mechanistic studies in vitro and in vivo reveal a surprising involvement of canonical Wnt signaling and epithelial-mesenchymal pathway in the FZD6-mediated invasive phenotype. Together, our stud …
FZD6 is a key gene that controls tissue polarity during development. ...Mechanistic studies in vitro and in vivo reveal a surprising …
Targeted alveolar regeneration with Frizzled-specific agonists.
Nabhan AN, Webster JD, Adams JJ, Blazer L, Everrett C, Eidenschenk C, Arlantico A, Fleming I, Brightbill HD, Wolters PJ, Modrusan Z, Seshagiri S, Angers S, Sidhu SS, Newton K, Arron JR, Dixit VM. Nabhan AN, et al. Cell. 2023 Jul 6;186(14):2995-3012.e15. doi: 10.1016/j.cell.2023.05.022. Epub 2023 Jun 14. Cell. 2023. PMID: 37321220 Free article.
Using an expanded repertoire of Fzd-Lrp agonists, we could activate canonical Wnt signaling in alveolar epithelial stem cells via either Fzd5 or, unexpectedly, non-canonical Fzd6. A Fzd5 agonist (Fzd5(ag)) or Fzd6(ag) stimulated alveolar epithelial stem cell activit …
Using an expanded repertoire of Fzd-Lrp agonists, we could activate canonical Wnt signaling in alveolar epithelial stem cells via either Fzd …
Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporotic Mice.
Wu T, Yao Z, Tao G, Lou F, Tang H, Gao Y, Yang X, Xiao J. Wu T, et al. Stem Cell Rev Rep. 2021 Oct;17(5):1889-1904. doi: 10.1007/s12015-021-10182-2. Epub 2021 May 26. Stem Cell Rev Rep. 2021. PMID: 34041696
METHODS: Fzd6 overexpression and silencing lentiviruses were used to evaluate the role of Fzd6 in the osteogenic differentiation of OP-ASCs. ...RESULTS: Expression of Fzd6 was decreased significantly in OP-ASCs. Fzd6 silencing down-regulated the osteog …
METHODS: Fzd6 overexpression and silencing lentiviruses were used to evaluate the role of Fzd6 in the osteogenic differentiati …
The prognostic role of FZD6 in esophageal squamous cell carcinoma patients.
Zhang J, Wang JL, Zhang CY, Ma YF, Zhao R, Wang YY. Zhang J, et al. Clin Transl Oncol. 2020 Jul;22(7):1172-1179. doi: 10.1007/s12094-019-02243-3. Epub 2019 Nov 20. Clin Transl Oncol. 2020. PMID: 31748958
Therefore, we finally used immunohistochemistry method to evaluate the effect of FZD6 on the prognosis of patients with ESCC. Additionally, we detected the expression level of FZD6 in ESCC cell line and normal esophageal epithelial cell line, and observed the cell v …
Therefore, we finally used immunohistochemistry method to evaluate the effect of FZD6 on the prognosis of patients with ESCC. Additio …
FZD6 triggers Wnt-signalling driven by WNT10B(IVS1) expression and highlights new targets in T-cell acute lymphoblastic leukemia.
Cassaro A, Grillo G, Notaro M, Gliozzo J, Esposito I, Reda G, Trojani A, Valentini G, Di Camillo B, Cairoli R, Beghini A. Cassaro A, et al. Hematol Oncol. 2021 Aug;39(3):364-379. doi: 10.1002/hon.2840. Epub 2021 Feb 16. Hematol Oncol. 2021. PMID: 33497493 Free PMC article.
Identifying Wnt agonists and antagonists, it results that the expression of FZD6, LRP5, and PROM1 genes stands out in WNT10B(IVS1) positive patients compared to negative ones. ...These results describe the molecular circuit induced by WNT10B and suggest WNT10B/FZD6 …
Identifying Wnt agonists and antagonists, it results that the expression of FZD6, LRP5, and PROM1 genes stands out in WNT10B(IVS1) po …
Comprehensive Genomic Analysis for Identifying FZD6 as a Novel Diagnostic Biomarker for Acute Myeloid Leukemia.
Yang L, Ma D, Tang S, Jiang T, Yu J, Wang L, Zou L. Yang L, et al. Comput Math Methods Med. 2022 Nov 18;2022:9130958. doi: 10.1155/2022/9130958. eCollection 2022. Comput Math Methods Med. 2022. PMID: 36452482 Free PMC article.

We identified that in the majority of 27 AML cell lines, frizzled class receptor 6 (FZD6) was high-expressed. A significantly higher expression of FZD6 in AML patients was observed when compared to normal controls (P < 0.01). ...However, the predictive effect of

…
We identified that in the majority of 27 AML cell lines, frizzled class receptor 6 (FZD6) was high-expressed. A significantly higher …
FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
Kim BK, Yoo HI, Kim I, Park J, Kim Yoon S. Kim BK, et al. BMB Rep. 2015 Jun;48(6):360-6. doi: 10.5483/bmbrep.2015.48.6.031. BMB Rep. 2015. PMID: 25772759 Free PMC article.
Additionally, we found that FZD6 expression was negatively regulated by miR199a5p in CRC cells. These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC....
Additionally, we found that FZD6 expression was negatively regulated by miR199a5p in CRC cells. These results suggest that overexpres …
CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/beta-catenin signaling pathway.
Han H, Xu M, Wang J, Li MD, Yang Z. Han H, et al. J Adv Res. 2024 Apr;58:129-138. doi: 10.1016/j.jare.2023.06.001. Epub 2023 Jun 14. J Adv Res. 2024. PMID: 37321345 Free PMC article.
In CRISPR/Cas9-based FZD6 knockdown cells, we showed that FZD6 plays a significant role in regulating expression of genes involved in Wnt/beta-catenin pathway. ...Moreover, decreased Gsk3beta mRNA expression, phosphorylated GSK3beta, and cytoplasmic beta-catenin in …
In CRISPR/Cas9-based FZD6 knockdown cells, we showed that FZD6 plays a significant role in regulating expression of genes invo …
262 results