G0901526/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2012	4
2013	3
2014	4
2015	2
2017	2
2018	1
2021	1
2022	1
2024	0

1

Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.

Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown CR, Hirt RP, Ranson NA, Melnikov SV. Nicholson D, et al. Nat Commun. 2022 Feb 1;13(1):591. doi: 10.1038/s41467-022-28281-0. Nat Commun. 2022. PMID: 35105900 Free PMC article.

2

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.

Salamina M, Montefiore BC, Liu M, Wood DJ, Heath R, Ault JR, Wang LZ, Korolchuk S, Baslé A, Pastok MW, Reeks J, Tatum NJ, Sobott F, Arold ST, Pagano M, Noble MEM, Endicott JA. Salamina M, et al. J Mol Biol. 2021 Mar 5;433(5):166795. doi: 10.1016/j.jmb.2020.166795. Epub 2021 Jan 7. J Mol Biol. 2021. PMID: 33422522 Free PMC article.

3

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

Hallett ST, Pastok MW, Morgan RML, Wittner A, Blundell KLIM, Felletar I, Wedge SR, Prodromou C, Noble MEM, Pearl LH, Endicott JA. Hallett ST, et al. Cell Rep. 2017 Oct 31;21(5):1386-1398. doi: 10.1016/j.celrep.2017.10.042. Cell Rep. 2017. PMID: 29091774 Free PMC article.

4

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.

Whittaker SR, Barlow C, Martin MP, Mancusi C, Wagner S, Self A, Barrie E, Te Poele R, Sharp S, Brown N, Wilson S, Jackson W, Fischer PM, Clarke PA, Walton MI, McDonald E, Blagg J, Noble M, Garrett MD, Workman P. Whittaker SR, et al. Mol Oncol. 2018 Mar;12(3):287-304. doi: 10.1002/1878-0261.12148. Epub 2018 Jan 28. Mol Oncol. 2018. PMID: 29063678 Free PMC article.

5

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Coxon CR, Anscombe E, Harnor SJ, Martin MP, Carbain B, Golding BT, Hardcastle IR, Harlow LK, Korolchuk S, Matheson CJ, Newell DR, Noble ME, Sivaprakasam M, Tudhope SJ, Turner DM, Wang LZ, Wedge SR, Wong C, Griffin RJ, Endicott JA, Cano C. Coxon CR, et al. J Med Chem. 2017 Mar 9;60(5):1746-1767. doi: 10.1021/acs.jmedchem.6b01254. Epub 2017 Feb 14. J Med Chem. 2017. PMID: 28005359 Free PMC article.

6

Identification and Characterization of an Irreversible Inhibitor of CDK2.

Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble ME, Wedge SR, Endicott JA, Griffin RJ. Anscombe E, et al. Chem Biol. 2015 Sep 17;22(9):1159-64. doi: 10.1016/j.chembiol.2015.07.018. Epub 2015 Aug 27. Chem Biol. 2015. PMID: 26320860 Free PMC article.

7

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM, Endicott JA. Brown NR, et al. Nat Commun. 2015 Apr 13;6:6769. doi: 10.1038/ncomms7769. Nat Commun. 2015. PMID: 25864384 Free PMC article.

8

Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.

Zaborowska J, Baumli S, Laitem C, O'Reilly D, Thomas PH, O'Hare P, Murphy S. Zaborowska J, et al. PLoS One. 2014 Sep 18;9(9):e107654. doi: 10.1371/journal.pone.0107654. eCollection 2014. PLoS One. 2014. PMID: 25233083 Free PMC article.

9

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.

Lu M, Zak J, Chen S, Sanchez-Pulido L, Severson DT, Endicott J, Ponting CP, Schofield CJ, Lu X. Lu M, et al. Cell. 2014 May 22;157(5):1130-45. doi: 10.1016/j.cell.2014.05.006. Cell. 2014. PMID: 24855949 Free article.

10

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

Echalier A, Hole AJ, Lolli G, Endicott JA, Noble ME. Echalier A, et al. ACS Chem Biol. 2014 Jun 20;9(6):1251-6. doi: 10.1021/cb500135f. Epub 2014 Apr 10. ACS Chem Biol. 2014. PMID: 24669831 Free PMC article.

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