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Linking H1 with chromatin and growth control.
Munro S, La Thangue NB. Munro S, et al. Mol Cell Oncol. 2017 Sep 21;4(6):e1360977. doi: 10.1080/23723556.2017.1360977. eCollection 2017. Mol Cell Oncol. 2017. PMID: 29209648 Free PMC article.
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, Fedorov O, Munro S, England KS, Nowak RP, Schofield CJ, La Thangue NB, Pawlyn C, Davies F, Morgan G, Athanasou N, Müller S, Oppermann U, Brennan PE. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380. doi: 10.1016/j.chembiol.2017.02.006. Epub 2017 Mar 2. Cell Chem Biol. 2017. PMID: 28262558 Free PMC article.
HDAC Inhibitors.
Olzscha H, Bekheet ME, Sheikh S, La Thangue NB. Olzscha H, et al. Methods Mol Biol. 2016;1436:281-303. doi: 10.1007/978-1-4939-3667-0_19. Methods Mol Biol. 2016. PMID: 27246222
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U. Johansson C, et al. Nat Chem Biol. 2016 Jul;12(7):539-45. doi: 10.1038/nchembio.2087. Epub 2016 May 23. Nat Chem Biol. 2016. PMID: 27214403
Regulation of actin nucleation and autophagosome formation.
Coutts AS, La Thangue NB. Coutts AS, et al. Cell Mol Life Sci. 2016 Sep;73(17):3249-63. doi: 10.1007/s00018-016-2224-z. Epub 2016 May 4. Cell Mol Life Sci. 2016. PMID: 27147468 Free PMC article. Review.
39 results