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Page 1
G3BP2: Structure and function.
Jin G, Zhang Z, Wan J, Wu X, Liu X, Zhang W. Jin G, et al. Pharmacol Res. 2022 Dec;186:106548. doi: 10.1016/j.phrs.2022.106548. Epub 2022 Nov 3. Pharmacol Res. 2022. PMID: 36336216 Free article. Review.
G3BP2 is abnormally expressed in many tumors and diseases, such as breast cancer, lung cancer, prostate cancer, cardiac hypertrophy, and atherosclerosis. Many researchers have found that G3BP2 may be a potential therapeutic target. In this revie …
G3BP2 is abnormally expressed in many tumors and diseases, such as breast cancer, lung cancer, prostate cancer, …
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
Li H, Lin PH, Gupta P, Li X, Zhao SL, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang DH, Chen ZS, Pawlik TM, Merritt RE, Ma J. Li H, et al. Mol Cancer. 2021 Sep 14;20(1):118. doi: 10.1186/s12943-021-01418-3. Mol Cancer. 2021. PMID: 34521423 Free PMC article.
Selective control of G3BP2/SG signaling is a potential means to treat non-small cell lung cancer (NSCLC). ...RESULTS: We show that MG53, a member of the TRIM protein family (TRIM72), modulates G3BP2 activity to control lung cancer progression. Loss of …
Selective control of G3BP2/SG signaling is a potential means to treat non-small cell lung cancer (NSCLC). ...RESULTS: We show …
RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2.
Chen Y, Zhou S, Wan K, Yu L, Zhao C, Deng H, Ou Q, Qin J, Hu J, Hou Z. Chen Y, et al. Oncogene. 2022 Jun;41(25):3433-3444. doi: 10.1038/s41388-022-02352-4. Epub 2022 May 19. Oncogene. 2022. PMID: 35589951
RIO Kinase 1 (RIOK1) is involved in various pathologies, including cancer. However, the role of RIOK1 in radioresistance of colorectal cancer (CRC) remains largely unknown. ...Furthermore, we found that RIOK1 and Ras-GAP SH3 domain binding protein 2 (G3BP2) i …
RIO Kinase 1 (RIOK1) is involved in various pathologies, including cancer. However, the role of RIOK1 in radioresistance of colorecta …
Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
Xia W, Chen W, Ni C, Meng X, Wu J, Yang Q, Tang H, Yuan H, Fang S. Xia W, et al. Breast Cancer Res. 2023 Jul 17;25(1):85. doi: 10.1186/s13058-023-01672-x. Breast Cancer Res. 2023. PMID: 37461019 Free PMC article.
Moreover, we found that miR-217 interacted with circBACH1 and targeted GTPase-activating SH3 domain-binding protein 2 (G3BP2) in BC cells. CircBACH1 combined miR-217 cotransfection suppressed the expression of G3BP2 proteins compared with circBACH1 treatment in MCF- …
Moreover, we found that miR-217 interacted with circBACH1 and targeted GTPase-activating SH3 domain-binding protein 2 (G3BP2) in BC c …
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). ...In the context of tumors, low G3BP1 levels enhance mTORC1-driven breast cancer cell motility and correlate wi …
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of st …
Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2.
Sheng Z, Wang X, Ding X, Zheng Y, Guo A, Cui J, Ma J, Duan W, Dong H, Zhang H, Cui M, Su W, Zhang B. Sheng Z, et al. Cell Signal. 2024 Jul;119:111182. doi: 10.1016/j.cellsig.2024.111182. Epub 2024 Apr 17. Cell Signal. 2024. PMID: 38640983 Free article.
Cancer-associated Fibroblasts (CAFs) exert a tumor-promoting effect in various cancers, including breast cancer. ...Overall, our study reveals that CAF-derived exosomal miR-92a serves as a promoter in the migration and invasion of breast cancer cells b …
Cancer-associated Fibroblasts (CAFs) exert a tumor-promoting effect in various cancers, including breast cancer. ...Ove …
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.
Wang N, Li T, Liu W, Lin J, Zhang K, Li Z, Huang Y, Shi Y, Xu M, Liu X. Wang N, et al. Cell Death Dis. 2023 Mar 6;14(3):182. doi: 10.1038/s41419-023-05706-2. Cell Death Dis. 2023. PMID: 36878903 Free PMC article.
Hyperactivation of G3BP2 is associated with various pathological conditions, especially cancers. ...Consistently, G3BP2, PRMT5 and G3BP2 R468me2 protein levels were found positively correlated in clinical patients and associated with poor prognosis. .. …
Hyperactivation of G3BP2 is associated with various pathological conditions, especially cancers. ...Consistently, G3BP2 …
alpha-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling.
Sun Y, Ding Y, Guo C, Liu C, Ma P, Ma S, Wang Z, Liu J, Qian T, Ma L, Deng Y, Wu C. Sun Y, et al. Oncogene. 2019 Jun;38(24):4856-4874. doi: 10.1038/s41388-019-0762-1. Epub 2019 Feb 25. Oncogene. 2019. PMID: 30804457
Importantly, the depletion of G3BP2 reverses the reduction in the level and signaling of TWIST1 and the suppression of breast cancer progression induced by the loss of alpha-parvin. Furthermore, the re-expression of an alpha-parvin mutant in which the G3BP2-b …
Importantly, the depletion of G3BP2 reverses the reduction in the level and signaling of TWIST1 and the suppression of breast canc …
Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer.
Ashikari D, Takayama K, Tanaka T, Suzuki Y, Obinata D, Fujimura T, Urano T, Takahashi S, Inoue S. Ashikari D, et al. Oncogene. 2017 Nov 9;36(45):6272-6281. doi: 10.1038/onc.2017.225. Epub 2017 Jul 10. Oncogene. 2017. PMID: 28692047
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including castration-resistant prostate cancer. ...Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2 …
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including cas …
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, Zhang X, Xing L. Liu B, et al. Oncogene. 2023 Apr;42(15):1181-1195. doi: 10.1038/s41388-023-02641-6. Epub 2023 Feb 23. Oncogene. 2023. PMID: 36823378
ETV4 is an oncogenic transcription factor frequently dysregulated in human cancer. We previously found that ETV4 is associated with tumor progression and poor prognosis in non-small cell lung cancer (NSCLC). ...Targeting ETV4-induced low-lactate stress is an importa …
ETV4 is an oncogenic transcription factor frequently dysregulated in human cancer. We previously found that ETV4 is associated with t …
55 results