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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 4
1994 7
1995 6
1996 9
1997 9
1998 5
1999 7
2000 7
2001 7
2002 5
2003 5
2004 10
2005 14
2006 7
2007 8
2008 13
2009 20
2010 14
2011 27
2012 29
2013 36
2014 58
2015 60
2016 57
2017 66
2018 62
2019 78
2020 73
2021 85
2022 88
2023 92
2024 33

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894 results

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Page 1
A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer.
Cao T, Lu Y, Wang Q, Qin H, Li H, Guo H, Ge M, Glass SE, Singh B, Zhang W, Dong J, Du F, Qian A, Tian Y, Wang X, Li C, Wu K, Fan D, Nie Y, Coffey RJ, Zhao X. Cao T, et al. J Clin Invest. 2022 Mar 15;132(6):e154074. doi: 10.1172/JCI154074. J Clin Invest. 2022. PMID: 35289315 Free PMC article.
De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease, trials combining chemotherapy and an anti-EGFR monoclonal antibody have been largely …
De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gast …
The role of GATA2 in lethal prostate cancer aggressiveness.
Rodriguez-Bravo V, Carceles-Cordon M, Hoshida Y, Cordon-Cardo C, Galsky MD, Domingo-Domenech J. Rodriguez-Bravo V, et al. Nat Rev Urol. 2017 Jan;14(1):38-48. doi: 10.1038/nrurol.2016.225. Epub 2016 Nov 22. Nat Rev Urol. 2017. PMID: 27872477 Free PMC article. Review.
The transcription factor endothelial transcription factor GATA-2 (GATA2) has been reported to have a key role in driving prostate cancer aggressiveness. ...Thus, GATA2 has a multifaceted function in prostate cancer aggressiveness and is a highly attrac …
The transcription factor endothelial transcription factor GATA-2 (GATA2) has been reported to have a key role in driving prostate …
A COP1-GATA2 axis suppresses AR signaling and prostate cancer.
Shen T, Dong B, Meng Y, Moore DD, Yang F. Shen T, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2205350119. doi: 10.1073/pnas.2205350119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36251994 Free PMC article.
While directly inhibiting GATA2 transcriptional activity remains challenging, enhancing GATA2 degradation is a plausible therapeutic strategy. ...Accordingly, GATA2 overexpression or COP1 mutations that disrupt COP1-GATA2 binding block COP1 tumor-suppr …
While directly inhibiting GATA2 transcriptional activity remains challenging, enhancing GATA2 degradation is a plausible thera …
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.
Mourkioti I, Polyzou A, Veroutis D, Theocharous G, Lagopati N, Gentile E, Stravokefalou V, Thanos DF, Havaki S, Kletsas D, Panaretakis T, Logothetis CJ, Stellas D, Petty R, Blandino G, Papaspyropoulos A, Gorgoulis VG. Mourkioti I, et al. J Exp Clin Cancer Res. 2023 Jul 29;42(1):187. doi: 10.1186/s13046-023-02769-z. J Exp Clin Cancer Res. 2023. PMID: 37507762 Free PMC article.
BACKGROUND: Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. ...We show that CDC6 loss is sufficient to reverse oncogenic features and induce senescence regardless of treatment responsiveness, thereby identifying CDC6 as a critica …
BACKGROUND: Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. ...We show that CDC6 loss is …
GATA2-Mediated Transcriptional Activation of Notch3 Promotes Pancreatic Cancer Liver Metastasis.
Lin H, Hu P, Zhang H, Deng Y, Yang Z, Zhang L. Lin H, et al. Mol Cells. 2022 May 31;45(5):329-342. doi: 10.14348/molcells.2022.2176. Mol Cells. 2022. PMID: 35534193 Free PMC article.
We correlated the difference in pathway activation with the expression of the four core transcriptional factors including STAT1, NR2F2, GATA2, and SMAD4. Using the TCGA database, we examined the relative expression of these transcription factors (TFs) in pan-cancer …
We correlated the difference in pathway activation with the expression of the four core transcriptional factors including STAT1, NR2F2, G …
Inhibition of GATA2 in prostate cancer by a clinically available small molecule.
Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Berman De Ruiz K, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. Kaochar S, et al. Endocr Relat Cancer. 2021 Nov 24;29(1):15-31. doi: 10.1530/ERC-21-0085. Endocr Relat Cancer. 2021. PMID: 34636746 Free PMC article.
The pioneer factor GATA2 is a significant prostate cancer (PC) driver and is linked to poor prognosis. ...We propose GATA2 as a therapeutic target in CRPC....
The pioneer factor GATA2 is a significant prostate cancer (PC) driver and is linked to poor prognosis. ...We propose GATA2 …
GATA2 deficiency.
Hsu AP, McReynolds LJ, Holland SM. Hsu AP, et al. Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):104-9. doi: 10.1097/ACI.0000000000000126. Curr Opin Allergy Clin Immunol. 2015. PMID: 25397911 Free PMC article. Review.
RECENT FINDINGS: GATA2 mutations have been found in up to 10% of those with congenital neutropenia and/or aplastic anemia. ...GATA2 deficiency is caused by a variety of mutations in the GATA2 gene and can have variable presentation, onset and outcome. ...
RECENT FINDINGS: GATA2 mutations have been found in up to 10% of those with congenital neutropenia and/or aplastic anemia. ...GATA …
Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes.
Sahoo SS, Kozyra EJ, Wlodarski MW. Sahoo SS, et al. Best Pract Res Clin Haematol. 2020 Sep;33(3):101197. doi: 10.1016/j.beha.2020.101197. Epub 2020 Jul 29. Best Pract Res Clin Haematol. 2020. PMID: 33038986 Free PMC article. Review.
The revised 2016 WHO classification introduced a novel category of "myeloid neoplasms with germline predisposition" with GATA2, CEBPA, DDX41, RUNX1, ANKRD26 and ETV6 genes expanding the spectrum of hereditary myeloid neoplasms (MN). ...To date, ~550 cases wit …
The revised 2016 WHO classification introduced a novel category of "myeloid neoplasms with germline predisposition" with GATA2 …
Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer.
Song SH, Jeon MS, Nam JW, Kang JK, Lee YJ, Kang JY, Kim HP, Han SW, Kang GH, Kim TY. Song SH, et al. Oncogene. 2018 Feb 22;37(8):993-1004. doi: 10.1038/onc.2017.397. Epub 2017 Nov 6. Oncogene. 2018. PMID: 29106391
Interestingly, we found that GATA6 was overexpressed in human gastric cancer cells only when GATA2 expression was completely absent, thereby showing an inverse correlation between GATA2 and GATA6. ...In contrast, GATA6 expression is undetectable in GATA2 …
Interestingly, we found that GATA6 was overexpressed in human gastric cancer cells only when GATA2 expression was completely a …
GATA2 and marrow failure.
Fabozzi F, Strocchio L, Mastronuzzi A, Merli P. Fabozzi F, et al. Best Pract Res Clin Haematol. 2021 Jun;34(2):101278. doi: 10.1016/j.beha.2021.101278. Epub 2021 Jun 17. Best Pract Res Clin Haematol. 2021. PMID: 34404529 Review.
GATA2 gene encodes a zinc finger transcription factor crucial for normal hematopoiesis. ...Currently, there are no consensus guidelines about the management of patients affected by GATA2 deficiency, especially with regard to the optimal time to proceed to HSCT....
GATA2 gene encodes a zinc finger transcription factor crucial for normal hematopoiesis. ...Currently, there are no consensus guidelin …
894 results