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Year Number of Results
1981 1
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1986 3
1987 2
1989 2
1991 1
1993 2
1995 2
1997 2
1998 4
1999 5
2000 6
2001 6
2002 13
2003 5
2004 5
2005 6
2006 14
2007 19
2008 20
2009 30
2010 23
2011 24
2012 30
2013 26
2014 37
2015 30
2016 29
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2018 45
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2020 33
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2022 56
2023 44
2024 21

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598 results

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Page 1
CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis.
Jiang Y, Zhao J, Li R, Liu Y, Zhou L, Wang C, Lv C, Gao L, Cui D. Jiang Y, et al. J Exp Clin Cancer Res. 2022 Oct 20;41(1):307. doi: 10.1186/s13046-022-02518-8. J Exp Clin Cancer Res. 2022. PMID: 36266731 Free PMC article.
Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via several mechanisms, including regulating iron metabolism, glutathione metabolism, lipid peroxidation and mitochondrial-related proteins, there are many novel circRNAs regulating ferroptosis need to b …
Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via several mechanisms, including regulating iron metabolism, g …
GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases.
Gupta P, Kumar R. Gupta P, et al. Gene. 2023 Dec 20;888:147749. doi: 10.1016/j.gene.2023.147749. Epub 2023 Aug 29. Gene. 2023. PMID: 37652170 Review.
Few single nucleotide polymorphisms of GCH1 gene are also responsible for pain in sickle cell disease. Furthermore, GCH1 regulates NO activity which controls the blood pressure, vasodilatory functions and oxidative stress. Understanding the therapeutic implications …
Few single nucleotide polymorphisms of GCH1 gene are also responsible for pain in sickle cell disease. Furthermore, GCH1 regul …
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis.
Xiao Y, Yuan Y, Yang Y, Liu B, Ding Z, Luo J, Chen S, Yu L. Xiao Y, et al. Inflamm Res. 2023 Nov;72(10-11):1941-1955. doi: 10.1007/s00011-023-01785-1. Epub 2023 Sep 21. Inflamm Res. 2023. PMID: 37735250
OBJECTIVE: GTP cyclohydrolase 1(GCH1) was reported to protect against ferroptosis. However, it is not clear whether GCH1 reduced lipopolysaccharide (LPS)-induced macrophage polarization and inflammation by inhibition of ferroptosis. ...Silence of GCH1 increas …
OBJECTIVE: GTP cyclohydrolase 1(GCH1) was reported to protect against ferroptosis. However, it is not clear whether GCH1 reduc …
GCH1 mutations in hereditary spastic paraplegia.
Varghaei P, Yoon G, Estiar MA, Veyron S, Leveille E, Dupré N, Trempe JF, Rouleau GA, Gan-Or Z. Varghaei P, et al. Clin Genet. 2021 Jul;100(1):51-58. doi: 10.1111/cge.13955. Epub 2021 Mar 18. Clin Genet. 2021. PMID: 33713342
Recently, GCH1 mutations have been reported in five patients with hereditary spastic paraplegia (HSP). ...In conclusion, GCH1 mutations may cause HSP; therefore, we suggest a levodopa trial in HSP patients and including GCH1 in the screening panels of HSP gen …
Recently, GCH1 mutations have been reported in five patients with hereditary spastic paraplegia (HSP). ...In conclusion, GCH1 …
GCH1, BH4 and pain.
Latremoliere A, Costigan M. Latremoliere A, et al. Curr Pharm Biotechnol. 2011 Oct;12(10):1728-41. doi: 10.2174/138920111798357393. Curr Pharm Biotechnol. 2011. PMID: 21466440 Free PMC article. Review.
These changes are principally due to the upregulation of the rate limiting enzyme for BH4 synthesis GTP Cyclohydrolase 1 (GCH1). A GCH1 pain-protective haplotype which decreases pain levels in a variety of settings, by reducing the levels of endogenous activation of …
These changes are principally due to the upregulation of the rate limiting enzyme for BH4 synthesis GTP Cyclohydrolase 1 (GCH1). A …
GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity.
Nasser A, Møller LB. Nasser A, et al. Scand J Pain. 2014 Apr 1;5(2):121-128. doi: 10.1016/j.sjpain.2013.12.001. Scand J Pain. 2014. PMID: 29913682 Free article. Review.
Studies assessing the role of GCH1 and BH4 in pain consist of human and animal studies, including DOPA-responsive dystonia (DRD) patients and hph-1 mice (a genetic mouse model of DRD) having mutations in the GCH1 gene as well as preclinical studies with the GCH1 …
Studies assessing the role of GCH1 and BH4 in pain consist of human and animal studies, including DOPA-responsive dystonia (DRD) pati …
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, Tan X, Zhang W, Han L, Zhang D, Feng H. Wang D, et al. Cell Death Differ. 2023 Feb;30(2):369-382. doi: 10.1038/s41418-022-01089-7. Epub 2022 Nov 28. Cell Death Differ. 2023. PMID: 36443440 Free PMC article.
Lipid peroxidation of ferroptosis in hSOD1G93A cells and mice was generated by TFR1-imported excess free iron, decreased GSH, mitochondrial membrane dysfunction, upregulated ALOX15, and inactivation of GCH1, GPX4. SPY1 is a "cyclin-like" protein that has been proved to enh …
Lipid peroxidation of ferroptosis in hSOD1G93A cells and mice was generated by TFR1-imported excess free iron, decreased GSH, mitochondrial …
GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis.
Larbalestier H, Keatinge M, Watson L, White E, Gowda S, Wei W, Koler K, Semenova SA, Elkin AM, Rimmer N, Sweeney ST, Mazzolini J, Sieger D, Hide W, McDearmid J, Panula P, MacDonald RB, Bandmann O. Larbalestier H, et al. J Neurosci. 2022 Jan 26;42(4):702-716. doi: 10.1523/JNEUROSCI.0653-21.2021. Epub 2021 Dec 7. J Neurosci. 2022. PMID: 34876467 Free PMC article.
To investigate the mechanisms by which GCH1 deficiency may contribute to PD, we generated a loss of function zebrafish gch1 mutant (gch1(-/-)), using CRISPR/Cas technology. gch1(-/-) zebrafish develop marked monoaminergic neurotransmitter deficiencies …
To investigate the mechanisms by which GCH1 deficiency may contribute to PD, we generated a loss of function zebrafish gch1 mu …
Dystonia.
Balint B, Mencacci NE, Valente EM, Pisani A, Rothwell J, Jankovic J, Vidailhet M, Bhatia KP. Balint B, et al. Nat Rev Dis Primers. 2018 Sep 20;4(1):25. doi: 10.1038/s41572-018-0023-6. Nat Rev Dis Primers. 2018. PMID: 30237473 Review.
In some of the most common genetic dystonias, such as those caused by TOR1A, THAP1, GCH1 and KMT2B mutations, and idiopathic dystonia, these mechanisms include abnormalities in transcriptional regulation, striatal dopaminergic signalling and synaptic plasticity and a loss …
In some of the most common genetic dystonias, such as those caused by TOR1A, THAP1, GCH1 and KMT2B mutations, and idiopathic dystonia …
New role for GCH1 in cancer.
Cronin SJF. Cronin SJF. Transl Breast Cancer Res. 2024 Apr 24;5:16. doi: 10.21037/tbcr-23-53. eCollection 2024. Transl Breast Cancer Res. 2024. PMID: 38751681 Free PMC article. No abstract available.
598 results