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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 3
1999 6
2000 7
2001 4
2002 7
2003 2
2004 1
2005 5
2006 1
2007 1
2008 1
2009 6
2010 6
2011 2
2012 3
2013 5
2014 7
2015 2
2016 8
2017 5
2018 11
2019 9
2020 13
2021 6
2022 8
2023 5
2024 2

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127 results

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Page 1
GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance.
Kim M, Kim DJ. Kim M, et al. Int J Mol Sci. 2018 Apr 4;19(4):1078. doi: 10.3390/ijms19041078. Int J Mol Sci. 2018. PMID: 29617307 Free PMC article. Review.
GFRA1 has also been implicated in cancer cell progression and metastasis. ...GFRA1-induced autophagy promoted tumor growth in mouse xenograft models, suggesting a novel function of GFRA1 in osteosarcoma chemoresistance....
GFRA1 has also been implicated in cancer cell progression and metastasis. ...GFRA1-induced autophagy promoted tumor gro …
Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux.
Ni B, He X, Zhang Y, Wang Z, Dong Z, Xia X, Zhao G, Cao H, Zhu C, Li Q, Liu J, Chen H, Zhang Z. Ni B, et al. Cell Oncol (Dordr). 2023 Apr;46(2):315-330. doi: 10.1007/s13402-022-00751-z. Epub 2023 Feb 20. Cell Oncol (Dordr). 2023. PMID: 36808605 Free PMC article.
PURPOSE: Liver metastasis, a lethal malignancy of gastric cancer (GC) patients, execrably impairs their prognosis. As yet, however, few studies have been designed to identify the driving molecules during its formation, except screening evidence pausing before their functio …
PURPOSE: Liver metastasis, a lethal malignancy of gastric cancer (GC) patients, execrably impairs their prognosis. As yet, however, f …
Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer.
Bosco EE, Christie RJ, Carrasco R, Sabol D, Zha J, DaCosta K, Brown L, Kennedy M, Meekin J, Phipps S, Ayriss J, Du Q, Bezabeh B, Chowdhury P, Breen S, Chen C, Reed M, Hinrichs M, Zhong H, Xiao Z, Dixit R, Herbst R, Tice DA. Bosco EE, et al. Oncotarget. 2018 May 1;9(33):22960-22975. doi: 10.18632/oncotarget.25160. eCollection 2018 May 1. Oncotarget. 2018. PMID: 29796165 Free PMC article.
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. ...Immunohistochemistry (IHC) revealed that GFRA1 displays a limited normal tissue expression profile coupled with overexpression in …
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. …
Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer.
Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ. Ma WR, et al. World J Gastroenterol. 2020 Jan 14;26(2):184-198. doi: 10.3748/wjg.v26.i2.184. World J Gastroenterol. 2020. PMID: 31988584 Free PMC article.
BACKGROUND: The expression of the membrane receptor protein GFRA1 is frequently upregulated in many cancers, which can promote cancer development by activating the classic RET-RAS-ERK and RET-RAS-PI3K-AKT pathways. ...However, it is unknown whether dmGFRA1 af …
BACKGROUND: The expression of the membrane receptor protein GFRA1 is frequently upregulated in many cancers, which can promote …
Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
Fan TC, Yeo HL, Hsu HM, Yu JC, Ho MY, Lin WD, Chang NC, Yu J, Yu AL. Fan TC, et al. Cancer Lett. 2018 Oct 10;434:184-195. doi: 10.1016/j.canlet.2018.07.026. Epub 2018 Jul 21. Cancer Lett. 2018. PMID: 30040982
GFRA1 and RET are overexpressed in estrogen receptor (ER)-positive breast cancers. ...Moreover, GDNF induced transcription of ST3GAL1, revealing a positive feedback loop regulating ST3GAL1 and GDNF/GFRA1/RET signaling in breast cancers. Finally, we dem …
GFRA1 and RET are overexpressed in estrogen receptor (ER)-positive breast cancers. ...Moreover, GDNF induced transcription of …
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer.
Meng M, Wu YC. Meng M, et al. J Immunol Res. 2022 Jul 4;2022:7375879. doi: 10.1155/2022/7375879. eCollection 2022. J Immunol Res. 2022. PMID: 35832649 Free PMC article.
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. ...Furthermore, by utilizing bioinformatics analysis, RIP, RNA pull-down, and luciferase reporter assays, our results showed that LMX1B could bind to …
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. ...Furthe …
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR. Bhakta S, et al. Mol Cancer Ther. 2018 Mar;17(3):638-649. doi: 10.1158/1535-7163.MCT-17-0813. Epub 2017 Dec 27. Mol Cancer Ther. 2018. PMID: 29282299
RNAseq and IHC analysis confirmed the abundant expression of GFRA1 in luminal A breast cancer tissues, whereas minimal or no expression was observed in most normal tissues. ...Overall, these data suggest that anti-GFRA1-vcMMAE ADC may provide a targeted thera …
RNAseq and IHC analysis confirmed the abundant expression of GFRA1 in luminal A breast cancer tissues, whereas minimal or no e …
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.
He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z, Tang H. He R, et al. J Exp Clin Cancer Res. 2017 Oct 16;36(1):145. doi: 10.1186/s13046-017-0614-1. J Exp Clin Cancer Res. 2017. PMID: 29037220 Free PMC article.
However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS: We performed circRNA microarrays to identify circRNAs that are aberrantly expressed in TNBC cell lines. ...Knockdown of circGFRA1 inhibited proliferation and promoted apo …
However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS: We performed circRNA microarra …
GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy.
Kim M, Jung JY, Choi S, Lee H, Morales LD, Koh JT, Kim SH, Choi YD, Choi C, Slaga TJ, Kim WJ, Kim DJ. Kim M, et al. Autophagy. 2017 Jan 2;13(1):149-168. doi: 10.1080/15548627.2016.1239676. Epub 2016 Oct 18. Autophagy. 2017. PMID: 27754745 Free PMC article.
We demonstrate that cisplatin treatment induced GFRA1 expression in human osteosarcoma cells. Induction of GFRA1 expression reduced cisplatin-induced apoptotic cell death and it significantly increased osteosarcoma cell survival via autophagy. ...Cisplatin-resistant …
We demonstrate that cisplatin treatment induced GFRA1 expression in human osteosarcoma cells. Induction of GFRA1 expression re …
CircRNA GFRA1 promotes hepatocellular carcinoma progression by modulating the miR-498/NAP1L3 axis.
Lv S, Li Y, Ning H, Zhang M, Jia Q, Wang X. Lv S, et al. Sci Rep. 2021 Jan 11;11(1):386. doi: 10.1038/s41598-020-79321-y. Sci Rep. 2021. PMID: 33431945 Free PMC article.
Circular RNAs (circRNAs) play essential roles in tumorigenesis and tumor progression. CircRNA GFRA1 (circGFRA1) was dysregulated in many cancer samples and acted as an independent marker for prediction of survivals in various cancer patients. ...
Circular RNAs (circRNAs) play essential roles in tumorigenesis and tumor progression. CircRNA GFRA1 (circGFRA1) was dysregulated in m …
127 results