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2023 7
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Page 1
Roles of DSCC1 and GINS1 in gastric cancer.
Hou S, Zhang J, Chi X, Li X, Zhang Q, Kang C, Shan H. Hou S, et al. Medicine (Baltimore). 2023 Oct 27;102(43):e35681. doi: 10.1097/MD.0000000000035681. Medicine (Baltimore). 2023. PMID: 37904396 Free PMC article.
The results of immune infiltration analysis showed that expression of T cell CD4 memory resting was lower in the samples of gastric cancer. The core genes (TRIP13, CHEK1, DSCC1, GINS1) are protective factors, their expression shows a downward trend with increase of …
The results of immune infiltration analysis showed that expression of T cell CD4 memory resting was lower in the samples of gastric cance
GINS1 Induced Sorafenib Resistance by Promoting Cancer Stem Properties in Human Hepatocellular Cancer Cells.
Li S, Wu L, Zhang H, Liu X, Wang Z, Dong B, Cao G. Li S, et al. Front Cell Dev Biol. 2021 Aug 3;9:711894. doi: 10.3389/fcell.2021.711894. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34414190 Free PMC article.
Spheroid formation assay results showed that GINS1 promoted the stem cell activity of HCC tumor cells. Furthermore, GEO database (GSE17112) analysis showed that HRAS oncogenic gene set was enriched in GINS1 high-expressed cancer cells, and quantitative real-t …
Spheroid formation assay results showed that GINS1 promoted the stem cell activity of HCC tumor cells. Furthermore, GEO database (GSE …
Identification of GINS1 as a therapeutic target in the cancer patients infected with COVID-19: a bioinformatics and system biology approach.
Hu C, Dai Y, Zhou H, Zhang J, Xie D, Xu R, Yang M, Zhang R. Hu C, et al. Hereditas. 2022 Dec 1;159(1):45. doi: 10.1186/s41065-022-00258-5. Hereditas. 2022. PMID: 36451247 Free PMC article.
RESULTS: We identified that Go-Ichi-Ni-San complex subunit 1 (GINS1) is the potential therapeutic target in Cancer/COVID-19 by GEPIA. The high expression of GINS1 was not only promoting the development of cancers but also affecting their prognosis. ...
RESULTS: We identified that Go-Ichi-Ni-San complex subunit 1 (GINS1) is the potential therapeutic target in Cancer/COVID-19 by …
Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.
Chen S, Zhang Y, Ding X, Li W. Chen S, et al. Front Genet. 2022 Mar 21;13:838869. doi: 10.3389/fgene.2022.838869. eCollection 2022. Front Genet. 2022. PMID: 35386284 Free PMC article.
Background: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer, with the incidence and mortality rates increasing every year. ...Clinical diagnostic and survival analyses demonstrated that the ZFAS1/hsa-miR-150-5p/GINS1 ceRNA regulatory axis ha …
Background: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer, with the incidence and mortality rates increasi …
Bioinformatics Analysis Identifies a Novel Role of GINS1 Gene in Colorectal Cancer.
Bu F, Zhu X, Zhu J, Liu Z, Wu T, Luo C, Lin K, Huang J. Bu F, et al. Cancer Manag Res. 2020 Nov 17;12:11677-11687. doi: 10.2147/CMAR.S279165. eCollection 2020. Cancer Manag Res. 2020. PMID: 33235499 Free PMC article.
Moreover, in vitro and in vivo experiments demonstrated GINS1 could promote the proliferation, invasion and migration of colorectal cancer cells. CONCLUSIONS: GINS1 could be considered as a potential biomarker for CRC patients....
Moreover, in vitro and in vivo experiments demonstrated GINS1 could promote the proliferation, invasion and migration of colorectal …
Up-regulation of GINS1 highlighted a good diagnostic and prognostic potential of survival in three different subtypes of human cancer.
Ahmad M, Hameed Y, Khan M, Usman M, Rehman A, Abid U, Asif R, Ahmed H, Hussain MS, Rehman JU, Asif HM, Arshad R, Atif M, Hadi A, Sarfraz U, Khurshid U. Ahmad M, et al. Braz J Biol. 2021 Nov 26;84:e250575. doi: 10.1590/1519-6984.250575. eCollection 2021. Braz J Biol. 2021. PMID: 34852135 Free article.
To investigate the GINS1 expression level and its prognostic value in distinct human cancers using a series of multi-layered in silico approach may help to establish it as a potential shared diagnostic and prognostic biomarker of different cancer subtypes. .. …
To investigate the GINS1 expression level and its prognostic value in distinct human cancers using a series of multi-layered i …
Complementary biomarkers of computed tomography for diagnostic grading of gastric cancer: DSCC1 and GINS1.
Zhu Y, Hou S, Kang C. Zhu Y, et al. Aging (Albany NY). 2024 Jan 31;16(5):4149-4168. doi: 10.18632/aging.205491. Epub 2024 Jan 31. Aging (Albany NY). 2024. PMID: 38301047 Free PMC article.
However, complementary markers for gastric cancer, relationship between DSCC1, GINS1 and gastric cancer remain unclear. ...WB and RT-PCR results demonstrated high expression of DSCC1 and GINS1 in gastric cancer. CONCLUSION: The expressions of DS …
However, complementary markers for gastric cancer, relationship between DSCC1, GINS1 and gastric cancer remain unclear. …
FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance.
Chen Z, Wang T, Li C, Zhang W, Huang W, Xue J, Wang J, Li S. Chen Z, et al. J Cancer. 2023 Jul 16;14(12):2289-2300. doi: 10.7150/jca.85906. eCollection 2023. J Cancer. 2023. PMID: 37576391 Free PMC article.
GINS1 is overexpressed in several types of cancers including leukemia and linked to poor outcomes. ...By EMSA, ChIP and luciferase reporter assays, it was found that FOXP1 transcriptionally activated GINS1 expression by directly binding to the promoter region
GINS1 is overexpressed in several types of cancers including leukemia and linked to poor outcomes. ...By EMSA, ChIP and lucife
GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A.
Yang H, Liu X, Zhu X, Zhang M, Wang Y, Ma M, Lv K. Yang H, et al. iScience. 2022 Aug 17;25(9):104952. doi: 10.1016/j.isci.2022.104952. eCollection 2022 Sep 16. iScience. 2022. PMID: 36065190 Free PMC article.
High expression of GINS1 predicted an advanced clinical grade and a poor survival. Functional assays revealed that GINS1 aggravated glioma malignant phenotypes in vitro and in vivo. Mechanistically, this study identified that GINS1 physically interacts with T …
High expression of GINS1 predicted an advanced clinical grade and a poor survival. Functional assays revealed that GINS1 aggra …
Expression Profile of GINS Complex Predicts the Prognosis of Pancreatic Cancer Patients.
Bu F, Zhu X, Yi X, Luo C, Lin K, Zhu J, Hu C, Liu Z, Zhao J, Huang C, Zhang W, Huang J. Bu F, et al. Onco Targets Ther. 2020 Nov 6;13:11433-11444. doi: 10.2147/OTT.S275649. eCollection 2020. Onco Targets Ther. 2020. PMID: 33192076 Free PMC article.
BACKGROUND: The GINS complex has been implicated in the prognosis of various cancers. It comprises four subunits, encoded by GINS1, GINS2, GINS3, and GINS4 genes. ...CONCLUSION: This work implicated GINS1, GINS2, GINS3, and GINS4 genes as critical prognostic …
BACKGROUND: The GINS complex has been implicated in the prognosis of various cancers. It comprises four subunits, encoded by GINS1
52 results