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15 results

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Page 1
Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis.
Petrosyan A, Holzapfel MS, Muirhead DE, Cheng PW. Petrosyan A, et al. Mol Cancer Res. 2014 Dec;12(12):1704-16. doi: 10.1158/1541-7786.MCR-14-0291-T. Epub 2014 Aug 1. Mol Cancer Res. 2014. PMID: 25086069 Free PMC article.
This property allows androgen-refractory prostate cancer cells to evade galectin-1 (LGALS1)-induced apoptosis, but the mechanism is not known. ...IMPLICATIONS: This study demonstrates the importance of Golgi morphology and regulation of glycosylation and provides insight i …
This property allows androgen-refractory prostate cancer cells to evade galectin-1 (LGALS1)-induced apoptosis, but the mechanism is n …
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Dmitriev AA, Kashuba VI, Haraldson K, Senchenko VN, Pavlova TV, Kudryavtseva AV, Anedchenko EA, Krasnov GS, Pronina IV, Loginov VI, Kondratieva TT, Kazubskaya TP, Braga EA, Yenamandra SP, Ignatjev I, Ernberg I, Klein G, Lerman MI, Zabarovsky ER. Dmitriev AA, et al. Epigenetics. 2012 May;7(5):502-13. doi: 10.4161/epi.19801. Epub 2012 May 1. Epigenetics. 2012. PMID: 22491060
Forty-four genes showed methylation and/or deletions in more than 15% of non-small cell lung cancer (NSCLC) samples. In general, SCC samples were more frequently methylated/deleted than ADC. ...A comprehensive statistical analysis suggested the set of 19 gene markers, ANKR …
Forty-four genes showed methylation and/or deletions in more than 15% of non-small cell lung cancer (NSCLC) samples. In general, SCC …
Epigenetic alterations of chromosome 3 revealed by NotI-microarrays in clear cell renal cell carcinoma.
Dmitriev AA, Rudenko EE, Kudryavtseva AV, Krasnov GS, Gordiyuk VV, Melnikova NV, Stakhovsky EO, Kononenko OA, Pavlova LS, Kondratieva TT, Alekseev BY, Braga EA, Senchenko VN, Kashuba VI. Dmitriev AA, et al. Biomed Res Int. 2014;2014:735292. doi: 10.1155/2014/735292. Epub 2014 May 22. Biomed Res Int. 2014. PMID: 24977159 Free PMC article.
These genes include tumor suppressors or candidates (VHL, CTDSPL, LRRC3B, ALDH1L1, and EPHB1) and genes that were not previously considered as cancer-associated (e.g., LRRN1, GORASP1, FGD5, and PLCL2). Bisulfite sequencing analysis confirmed methylation as a frequen …
These genes include tumor suppressors or candidates (VHL, CTDSPL, LRRC3B, ALDH1L1, and EPHB1) and genes that were not previously considered …
Markers of malignant prostate cancer cells: Golgi localization of alpha-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface.
Cheng PW, Davidson S, Bhat G. Cheng PW, et al. Biochem Biophys Res Commun. 2020 Jun 25;527(2):406-410. doi: 10.1016/j.bbrc.2020.03.168. Epub 2020 Apr 22. Biochem Biophys Res Commun. 2020. PMID: 32331836 Free PMC article.
The ability to distinguish malignant from indolent prostate cancer cells is critically important for identification of clinically significant prostate cancer to minimize unnecessary overtreatment and sufferings endured by patients who have indolent cancer. .. …
The ability to distinguish malignant from indolent prostate cancer cells is critically important for identification of clinically sig …
Gene expression profile predicts response to the combination of tosedostat and low-dose cytarabine in elderly AML.
Visani G, Loscocco F, Dennis M, Zuffa E, Candoni A, Sensi A, Giannini B, Musuraca G, Mianulli AM, Clavio M, Rocchi M, Gibellini D, Navari M, Gilkes A, Piccaluga PP, Isidori A. Visani G, et al. Blood Adv. 2020 Oct 27;4(20):5040-5049. doi: 10.1182/bloodadvances.2020002305. Blood Adv. 2020. PMID: 33075137 Free PMC article.
Tosedostat is an orally administered metalloenzyme inhibitor with antiproliferative and antiangiogenic activity against hematological and solid human cancers. Clinical activity has been demonstrated in relapsed acute myeloid leukemia (AML). ...A microarray analysis perform …
Tosedostat is an orally administered metalloenzyme inhibitor with antiproliferative and antiangiogenic activity against hematological and so …
Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells.
Wang F, Chen X, Yuan D, Yi Y, Luo Y. Wang F, et al. PLoS One. 2019 Nov 26;14(11):e0225450. doi: 10.1371/journal.pone.0225450. eCollection 2019. PLoS One. 2019. PMID: 31770410 Free PMC article.
Dihydromyricetin (DHM) has demonstrated antitumor activity in different types of human cancers. However, the pharmacological effects of DHM on ovarian cancer (OC) and the molecular mechanisms that underlie these effects are largely unknown. ...Taken together, these …
Dihydromyricetin (DHM) has demonstrated antitumor activity in different types of human cancers. However, the pharmacological effects …
An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies.
Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER. Protopopov A, et al. Cancer Res. 2003 Jan 15;63(2):404-12. Cancer Res. 2003. PMID: 12543795
Furthermore, three new genes were isolated, namely the human homologue to the rat Golgi peripheral membrane protein p65, GOLPH5 (GORASP1), the gene for stress-inducible protein, STI2, and the AP20-region gene 1, APRG1. The tumor suppressor gene candidate APRG1 was position …
Furthermore, three new genes were isolated, namely the human homologue to the rat Golgi peripheral membrane protein p65, GOLPH5 (GORASP1 …
Shifted Golgi targeting of glycosyltransferases and alpha-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.
Bhat G, Hothpet VR, Lin MF, Cheng PW. Bhat G, et al. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2891-2901. doi: 10.1016/j.bbagen.2017.08.006. Epub 2017 Aug 4. Biochim Biophys Acta Gen Subj. 2017. PMID: 28782625
BACKGROUND: There is a pressing need for biomarkers that can distinguish indolent from aggressive prostate cancer to prevent over-treatment of patients with indolent tumor. ...RESULTS: Defective giantin in androgen-independent prostate cancer cells results in a shif …
BACKGROUND: There is a pressing need for biomarkers that can distinguish indolent from aggressive prostate cancer to prevent over-tre …
15 results