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Year | Number of Results |
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2013 | 1 |
2019 | 2 |
2023 | 1 |
2024 | 0 |
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Page 1
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
Mol Cell. 2019 Apr 4;74(1):45-58.e7. doi: 10.1016/j.molcel.2019.01.037. Epub 2019 Mar 4.
Mol Cell. 2019.
PMID: 30846317
Free PMC article.
Loss of CHP1 severely reduces fatty acid incorporation and storage in mammalian cells and invertebrates. Mechanistically, CHP1 binds and activates GPAT4, which catalyzes the initial rate-limiting step in glycerolipid synthesis. GPAT4 activity requires CHP1 to be N-m …
Loss of CHP1 severely reduces fatty acid incorporation and storage in mammalian cells and invertebrates. Mechanistically, CHP1 binds and act …
Establishment of a prognostic model for ovarian cancer based on mitochondrial metabolism-related genes.
Meng C, Sun Y, Liu G.
Meng C, et al.
Front Oncol. 2023 May 15;13:1144430. doi: 10.3389/fonc.2023.1144430. eCollection 2023.
Front Oncol. 2023.
PMID: 37256178
Free PMC article.
METHODS: First of all, screened differentially expressed genes (DEGs) between TCGA-HGSOC and GTEx-normal by limma, with RNA-seq related HGSOC sourced from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database. ...The study structured a MMRGs-rel …
METHODS: First of all, screened differentially expressed genes (DEGs) between TCGA-HGSOC and GTEx-normal by limma, with RNA-seq related HGSO …
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Transcriptional Regulation of Acyl-CoA:Glycerol-sn-3-Phosphate Acyltransferases.
Karasawa K, Tanigawa K, Harada A, Yamashita A.
Karasawa K, et al.
Int J Mol Sci. 2019 Feb 22;20(4):964. doi: 10.3390/ijms20040964.
Int J Mol Sci. 2019.
PMID: 30813330
Free PMC article.
Review.
The enzymes of mammalian species are classified into four isoforms; GPAT1 and GPAT2 are localized in the mitochondrial outer membrane, whereas GPAT3 and GPAT4 are localized in the endoplasmic reticulum membrane. The activity of each enzyme expressed is associated with phys …
The enzymes of mammalian species are classified into four isoforms; GPAT1 and GPAT2 are localized in the mitochondrial outer membrane, where …
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Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.
Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA.
Wendel AA, et al.
J Biol Chem. 2013 Sep 20;288(38):27299-27306. doi: 10.1074/jbc.M113.485219. Epub 2013 Aug 1.
J Biol Chem. 2013.
PMID: 23908354
Free PMC article.
Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separate gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are GPAT1 and GPAT4. To determine whether each of these hepatic isoforms performs a unique function …
Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separate gene, catalyze the initial step in glycerolipid synthe …
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