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GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.
Liu J, Pan L, Hong W, Chen S, Bai P, Luo W, Sun X, He F, Jia X, Cai J, Chen Y, Hu K, Song Z, Ge J, Sun A. Liu J, et al. Nat Commun. 2022 Dec 6;13(1):7519. doi: 10.1038/s41467-022-35159-8. Nat Commun. 2022. PMID: 36473866 Free PMC article.
Here, we show that genetic deletion of GPR174 in Tregs potentiated blood flow recovery in mice after hindlimb ischemia. ...Collectively, these findings demonstrate that GPR174 negatively regulates angiogenesis and vascular remodeling in response to ischemic injury a …
Here, we show that genetic deletion of GPR174 in Tregs potentiated blood flow recovery in mice after hindlimb ischemia. ...Collective …
Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice.
Qiu D, Chu X, Hua L, Yang Y, Li K, Han Y, Yin J, Zhu M, Mu S, Sun Z, Tong C, Song Z. Qiu D, et al. Cell Death Dis. 2019 Mar 8;10(3):233. doi: 10.1038/s41419-019-1462-z. Cell Death Dis. 2019. PMID: 30850582 Free PMC article.
G protein-coupled receptor 174 (GPR174) is mainly expressed in thymus, spleen, lymph nodes, and leukocytes, and genetic variation in GPR174 is associated with susceptibility to autoimmune diseases, indicating that GPR174 is involved in the immune response. .. …
G protein-coupled receptor 174 (GPR174) is mainly expressed in thymus, spleen, lymph nodes, and leukocytes, and genetic variation in …
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Zhao Y, Hasse S, Bourgoin SG. Zhao Y, et al. Prog Lipid Res. 2021 Jul;83:101112. doi: 10.1016/j.plipres.2021.101112. Epub 2021 Jun 22. Prog Lipid Res. 2021. PMID: 34166709 Review.
Maturation and functions of many immune cells, such as T cells, dendritic cells, macrophages, and mast cells, can be regulated by PLA1A and lysoPS. Several lysoPS receptors, including GPR34, GPR174 and P2Y10, have been identified. High serum levels and high PLA1A expressio …
Maturation and functions of many immune cells, such as T cells, dendritic cells, macrophages, and mast cells, can be regulated by PLA1A and …
Screening of T Cell-Related Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks in Non-Small-Cell Lung Cancer.
Duan J, Pan Y, Yang X, Zhong L, Jin Y, Xu J, Zhuang J, Han S. Duan J, et al. Biomed Res Int. 2020 Nov 14;2020:5816763. doi: 10.1155/2020/5816763. eCollection 2020. Biomed Res Int. 2020. PMID: 33274216 Free PMC article.
BACKGROUND: Lung cancer (LC) has the highest mortality rate among all the other types of cancer in the world. ...GPR174 was found to be regulated by hsa-miR-19b-5p and hsa-miR-19b-2-5p, and both of these two miRNAs were regulated by lncRNA PCED1B-AS1. ...
BACKGROUND: Lung cancer (LC) has the highest mortality rate among all the other types of cancer in the world. ...GPR174 …
Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.
Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. Qin Y, et al. Pigment Cell Melanoma Res. 2011 Feb;24(1):207-18. doi: 10.1111/j.1755-148X.2010.00781.x. Epub 2010 Oct 21. Pigment Cell Melanoma Res. 2011. PMID: 20880198
G-protein-coupled receptors (GPCRs) have been implicated in the tumorigenesis and metastasis of human cancers and are considered amongst the most desirable targets for drug development. Utilizing a robust quantitative PCR array, we quantified expression of 94 human GPCRs, …
G-protein-coupled receptors (GPCRs) have been implicated in the tumorigenesis and metastasis of human cancers and are considered amon …