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Page 1
Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma.
Ye Y, Scheff NN, Bernabé D, Salvo E, Ono K, Liu C, Veeramachaneni R, Viet CT, Viet DT, Dolan JC, Schmidt BL. Ye Y, et al. Neuropharmacology. 2018 Sep 1;139:182-193. doi: 10.1016/j.neuropharm.2018.07.016. Epub 2018 Jul 20. Neuropharmacology. 2018. PMID: 30009833
We found down-regulated mRNA levels of GPR18 and GPR32 (which code for receptors RvD1 and RvD2) in oral cancer cells. ...Using a cancer supernatant model, we demonstrated that RvD2 reduced cancer-derived cytokines/chemokines (TNF-alpha, IL-6, CXCL10, a …
We found down-regulated mRNA levels of GPR18 and GPR32 (which code for receptors RvD1 and RvD2) in oral cancer cells. ...Using …
Resolvin D1 inhibits TGF-beta1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32.
Lee HJ, Park MK, Lee EJ, Lee CH. Lee HJ, et al. Int J Biochem Cell Biol. 2013 Dec;45(12):2801-7. doi: 10.1016/j.biocel.2013.09.018. Epub 2013 Oct 10. Int J Biochem Cell Biol. 2013. PMID: 24120851
The effects of resolvin D1 and D2 were confirmed in other lung cancer cell lines such as H838, H1299, and H1703. Resolvin D1 and D2 did not affect the proliferation of A549 lung cancer cells. ...Gene silencing of ALX/FPR2 and GPR32 blocked the action of resol …
The effects of resolvin D1 and D2 were confirmed in other lung cancer cell lines such as H838, H1299, and H1703. Resolvin D1 and D2 d …
The role of Resolvin D1 in liver diseases.
Yang M, Song XQ, Han M, Liu H. Yang M, et al. Prostaglandins Other Lipid Mediat. 2022 Jun;160:106634. doi: 10.1016/j.prostaglandins.2022.106634. Epub 2022 Mar 12. Prostaglandins Other Lipid Mediat. 2022. PMID: 35292355 Free article. Review.
Resolvin D1, a member of the specialized pro-resolving lipid mediators family, exerts anti-inflammatory, anti-oxidant stress, anti-fibrosis, anti-apoptotic, and anti-tumor effects by binding to ALX/FPR2 or GPR32. RvD1 plays an important role and has great therapeutic poten …
Resolvin D1, a member of the specialized pro-resolving lipid mediators family, exerts anti-inflammatory, anti-oxidant stress, anti-fibrosis, …
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways.
Prevete N, Liotti F, Illiano A, Amoresano A, Pucci P, de Paulis A, Melillo RM. Prevete N, et al. Oncoimmunology. 2017 Feb 21;6(4):e1293213. doi: 10.1080/2162402X.2017.1293213. eCollection 2017. Oncoimmunology. 2017. PMID: 28507800 Free PMC article.
SPM treatment of GC cells abated their angiogenic potential. Genetic deletion of ALOX15 or of the RvD1 receptor GPR32 increased the angiogenic and tumorigenic activity of GC cells thereby mimicking FPR1 loss. Deletion/inhibition of ALOX5/15 or GPR32 blocked FPR1-med …
SPM treatment of GC cells abated their angiogenic potential. Genetic deletion of ALOX15 or of the RvD1 receptor GPR32 increased the a …
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.
Bäck M, Powell WS, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GE. Bäck M, et al. Br J Pharmacol. 2014 Aug;171(15):3551-74. doi: 10.1111/bph.12665. Epub 2014 Jul 12. Br J Pharmacol. 2014. PMID: 24588652 Free PMC article. Review.
The aim of the present review is to give a state of the field on these receptors, with focus on recent important findings. For example, BLT1 receptor signalling in cancer and the dual role of the BLT2 receptor in pro- and anti-inflammatory actions have added more complexit …
The aim of the present review is to give a state of the field on these receptors, with focus on recent important findings. For example, BLT1 …
New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery.
Park J, Langmead CJ, Riddy DM. Park J, et al. ACS Pharmacol Transl Sci. 2020 Jan 20;3(1):88-106. doi: 10.1021/acsptsci.9b00075. eCollection 2020 Feb 14. ACS Pharmacol Transl Sci. 2020. PMID: 32259091 Free PMC article. Review.
Chronic inflammation is a component of numerous diseases including autoimmune, metabolic, neurodegenerative, and cancer. The discovery and characterization of specialized pro-resolving mediators (SPMs) critical to the resolution of inflammation, and their cognate G protein …
Chronic inflammation is a component of numerous diseases including autoimmune, metabolic, neurodegenerative, and cancer. The discover …
Functional study of acetaldehyde dehydrogenase 1 (ALDH1) in keratinocytes: microarray integrating bioinformatics approaches.
Yin SJ, Park MW, Lee BN, Yang JM, Park YD, Qian GY. Yin SJ, et al. J Biomol Struct Dyn. 2021 Apr;39(6):2133-2151. doi: 10.1080/07391102.2020.1745281. Epub 2020 Apr 7. J Biomol Struct Dyn. 2021. PMID: 32189581
The function of acetaldehyde dehydrogenase 1 (ALDH1) has been gradually elucidated in several diseases, especially in various cancers. However, the role of ALDH1 in skin-related diseases has been mostly unknown. ...Together, those tests identified several novel genes assoc …
The function of acetaldehyde dehydrogenase 1 (ALDH1) has been gradually elucidated in several diseases, especially in various cancers
ResolvinD1 attenuates high-mobility group box 1-induced epithelial-to-mesenchymal transition in nasopharyngeal carcinoma cells.
Yang P, Chen S, Zhong G, Wang Y, Kong W, Wang Y. Yang P, et al. Exp Biol Med (Maywood). 2019 Dec;244(18):1608-1618. doi: 10.1177/1535370219885320. Epub 2019 Nov 1. Exp Biol Med (Maywood). 2019. PMID: 31675905 Free PMC article.
RvD1 suppressed HMGB1-induced EMT in NPC cells via ALX/FPR2 and GPR32 receptors. These results showed that EMT was obvious in NPC. ...HMGB1, as an important inflammatory factor, promotes the process in many cancers. But little is known about how HMGB1 affects the pr …
RvD1 suppressed HMGB1-induced EMT in NPC cells via ALX/FPR2 and GPR32 receptors. These results showed that EMT was obvious in NPC. .. …