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18 results

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miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-kappaB pathway.
Zhou W, Li P, Jin P. Zhou W, et al. Open Med (Wars). 2021 Nov 9;16(1):1683-1695. doi: 10.1515/med-2021-0369. eCollection 2021. Open Med (Wars). 2021. PMID: 34805531 Free PMC article.
Moreover, our findings showed that miR-654-5p was bound with GPRIN1. Importantly, downregulation of GPRIN1 rescued the inhibitory influence of miR-654-5p knockdown on GC cell malignant behaviors. Additionally, miR-654-5p activated the nuclear factor kappa-B (NF-kapp …
Moreover, our findings showed that miR-654-5p was bound with GPRIN1. Importantly, downregulation of GPRIN1 rescued the inhibit …
G protein regulated inducer of neurite outgrowth 1 is a potential marker for lung cancer prognosis.
Zhuang MQ, Li J, Han X, Su KL, Hao GJ, Han JQ. Zhuang MQ, et al. J Biol Regul Homeost Agents. 2020 May-Jun;34(3):853-864. doi: 10.23812/20-136-A-39. J Biol Regul Homeost Agents. 2020. PMID: 32755106
To detect the functional effects of knockdown/overexpression of GPRIN1 on lung cancer cells, we performed CCK-8, colony formation and Transwell assays. ...Furthermore, the mRNA and protein expression levels of GPRIN1 in lung cancer cells were markedly …
To detect the functional effects of knockdown/overexpression of GPRIN1 on lung cancer cells, we performed CCK-8, colony format …
Dynamic network biomarker to determine the critical point of breast cancer stage progression.
Jiang F, Yang L, Jiao X. Jiang F, et al. Breast Cancer. 2023 May;30(3):453-465. doi: 10.1007/s12282-023-01438-5. Epub 2023 Feb 18. Breast Cancer. 2023. PMID: 36807044
RESULTS: We identified a set of gene clusters with the highest CI in Stage II as DNBs, whose roles in related pathways indicate the emergence of a tipping point and impact on breast cancer development. In addition, analysis of the key gene GPRIN1 showed that high ex …
RESULTS: We identified a set of gene clusters with the highest CI in Stage II as DNBs, whose roles in related pathways indicate the emergenc …
Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility.
Marinelli LM, Kisiel JB, Slettedahl SW, Mahoney DW, Lemens MA, Shridhar V, Taylor WR, Staub JK, Cao X, Foote PH, Burger KN, Berger CK, O'Connell MC, Doering KA, Giakoumopoulos M, Berg H, Volkmann C, Solsrud A, Allawi HT, Kaiser M, Vaccaro AM, Albright Crawford C, Moehlenkamp C, Shea G, Deist MS, Schoolmeester JK, Kerr SE, Sherman ME, Bakkum-Gamez JN. Marinelli LM, et al. Gynecol Oncol. 2022 Jun;165(3):568-576. doi: 10.1016/j.ygyno.2022.03.018. Epub 2022 Mar 31. Gynecol Oncol. 2022. PMID: 35370009 Free PMC article.
OBJECTIVE: Aberrant DNA methylation is an early event in carcinogenesis which could be leveraged to detect ovarian cancer (OC) in plasma. METHODS: DNA from frozen OC tissues, benign fallopian tube epithelium (FTE), and buffy coats from cancer-free women underwent re …
OBJECTIVE: Aberrant DNA methylation is an early event in carcinogenesis which could be leveraged to detect ovarian cancer (OC) in pla …
A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma.
Zhou Q, Li D, Zheng H, He Z, Qian F, Wu X, Yin Z, Bao PT, Jin M. Zhou Q, et al. Thorac Cancer. 2021 Oct;12(19):2526-2536. doi: 10.1111/1759-7714.14129. Epub 2021 Aug 28. Thorac Cancer. 2021. PMID: 34453499 Free PMC article.
METHODS: First, a pan-cancer correlation analysis was conducted on the expression and prognosis of GPRIN1 based on the data downloaded from The Cancer Genome Atlas (TCGA) database. ...Finally, the correlation analysis was made on GPRIN1 and immune chec …
METHODS: First, a pan-cancer correlation analysis was conducted on the expression and prognosis of GPRIN1 based on the data do …
Comprehensive Analysis of the Transcriptome-wide m6A Methylome in Lung Adenocarcinoma by MeRIP Sequencing.
Mao W, Yu Q, Wang K, Ma Q, Zheng Y, Zhang G, Luo W, Wang N, Wang Y. Mao W, et al. Front Oncol. 2022 Jul 11;12:791332. doi: 10.3389/fonc.2022.791332. eCollection 2022. Front Oncol. 2022. PMID: 35903698 Free PMC article.
To further explore the relationship between differential m6A modified genes and clinical parameters of LUAD patients, we searched The Cancer Genome Atlas (TCGA) and identified 2 genes (FCRL5 and GPRIN1) that were associated with the prognosis and diagnosis of LUAD p …
To further explore the relationship between differential m6A modified genes and clinical parameters of LUAD patients, we searched The Can …
Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1.
Cui X, Zhang B, Li B, Li X. Cui X, et al. Bioengineered. 2022 Apr;13(4):9070-9085. doi: 10.1080/21655979.2022.2053803. Bioengineered. 2022. PMID: 35293280 Free PMC article.
MiR-585-3p knockdown alleviated the influence of circ_0002360 silence on Taxol-resistant cells. GPRIN1 was directly targeted by miR-585-3p. The influence of miR-585-3p on cell Taxol resistance and functional behaviors was reversed by GPRIN1 overexpression. Moreover, …
MiR-585-3p knockdown alleviated the influence of circ_0002360 silence on Taxol-resistant cells. GPRIN1 was directly targeted by miR-5 …
Potential Immune Biomarker Candidates and Immune Subtypes of Lung Adenocarcinoma for Developing mRNA Vaccines.
Wang Y, Tan H, Yu T, Chen X, Jing F, Shi H. Wang Y, et al. Front Immunol. 2021 Nov 30;12:755401. doi: 10.3389/fimmu.2021.755401. eCollection 2021. Front Immunol. 2021. PMID: 34917077 Free PMC article.
mRNA vaccines against cancer have advantages in safety, improved therapeutic efficacy, and large-scale production. ...LUAD patients are classified into four signatures: T >C, APOBEC mutation, age, and tobacco. Then, GPRIN1, MYRF, PLXNB2, SLC9A4, TRIM29, UBA6, and …
mRNA vaccines against cancer have advantages in safety, improved therapeutic efficacy, and large-scale production. ...LUAD patients a …
A Hypoxia-Related Signature for Predicting Prognosis, Cellular Processes, Immune Microenvironment and Targeted Compounds in Lung Squamous Cell Carcinoma.
Wu G, Zhu Z, Yang Z, He M, Ren K, Dong Y, Xue Q. Wu G, et al. Int J Gen Med. 2022 Apr 12;15:3991-4006. doi: 10.2147/IJGM.S344228. eCollection 2022. Int J Gen Med. 2022. PMID: 35437352 Free PMC article.
METHODS: The transcriptome data and matched clinical information of LUSC were retrieved from The Cancer Genome Atlas (TCGA) database. The GSVA algorithm calculated each LUSC patient's hypoxia score, and all LUSC patients were divided into the high hypoxia score group and l …
METHODS: The transcriptome data and matched clinical information of LUSC were retrieved from The Cancer Genome Atlas (TCGA) database. …
A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.
Curtis VF, Wang H, Yang P, McLendon RE, Li X, Zhou QY, Wang XF. Curtis VF, et al. PLoS One. 2013;8(1):e54916. doi: 10.1371/journal.pone.0054916. Epub 2013 Jan 23. PLoS One. 2013. PMID: 23372791 Free PMC article.
Neutralizing antibodies against PK2 were shown to display potent anti-tumor efficacy, illustrating the potential of PK2-antagonists as therapeutic agents for the treatment of cancer. In this study we demonstrate the anti-tumor activity of a small molecule PK2 antagonist, P …
Neutralizing antibodies against PK2 were shown to display potent anti-tumor efficacy, illustrating the potential of PK2-antagonists as thera …
18 results