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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2007 1
2009 3
2010 3
2011 1
2012 2
2014 7
2015 5
2016 5
2017 4
2018 6
2019 3
2020 2
2021 6
2022 3
2023 3
2024 0

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45 results

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Page 1
G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor.
Si Y, Zhang H, Peng P, Zhu C, Shen J, Xiong Y, Liu X, Xiang Y, Li W, Ren Y, Wan F, Zhang L, Liu Y. Si Y, et al. Cancer Sci. 2021 Dec;112(12):4867-4882. doi: 10.1111/cas.15151. Epub 2021 Oct 20. Cancer Sci. 2021. PMID: 34609770 Free PMC article.
However, the biological functions of GPS2 in cancer, as well as the underlying molecular mechanisms, remain poorly understood. Here, we report that GPS2 expression was aberrantly downregulated in gastric cancer (GC) tissues compared with control tissue …
However, the biological functions of GPS2 in cancer, as well as the underlying molecular mechanisms, remain poorly understood. …
Recurrent FOXK1::GRHL and GPS2::GRHL fusions in trichogerminoma.
Kervarrec T, Pissaloux D, Poilane J, Tirode F, Tallet A, Collin C, Tallegas M, Berthon P, Gaboriaud P, Sohier P, Calonje E, Luzar B, Goto K, Cokelaere K, Lamant L, Balme B, Wild R, Neuville A, Deschamps L, Auberger E, Paumier V, Bonte H, Moulonguet I, Plantier F, Cales V, Pinsolle V, Roblet D, Dupuy F, Dallot A, Seris A, Jouary T, Houben R, Schrama D, Hesbacher S, Macagno N, Battistella M, Cribier B, Vergier B, de la Fouchardière A, Jullie ML. Kervarrec T, et al. J Pathol. 2022 May;257(1):96-108. doi: 10.1002/path.5872. Epub 2022 Mar 28. J Pathol. 2022. PMID: 35049062
We report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in-frame fusion transcripts. Microscopic examination of a preliminary set of five cases revealed well-delimitated tumours located in the dermis with frequent extension …
We report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in-frame fusion transcripts …
Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling.
Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Chan S, et al. Front Cell Dev Biol. 2021 Jan 7;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33490071 Free PMC article.
However, molecular mechanisms by which GPS2 prevents cancer development and/or progression are largely unknown. ...Collectively, these observations confirm a tumor suppressor role for GPS2 and reveal that loss of GPS2 promotes breast cancer cell …
However, molecular mechanisms by which GPS2 prevents cancer development and/or progression are largely unknown. ...Collectivel …
G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.
Cheng X, Kao HY. Cheng X, et al. J Biol Chem. 2009 Dec 25;284(52):36395-36404. doi: 10.1074/jbc.M109.062109. Epub 2009 Oct 26. J Biol Chem. 2009. PMID: 19858209 Free PMC article.
Knockdown of GPS2 abrogates, whereas overexpression potentiates, SMRT-mediated repression activity. ...Finally, we show that depletion of GPS2 or SMRT by siRNA promotes cell proliferation in MCF-7 breast cancer cells. ...
Knockdown of GPS2 abrogates, whereas overexpression potentiates, SMRT-mediated repression activity. ...Finally, we show that depletio …
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
Wong MM, Guo C, Zhang J. Wong MM, et al. Am J Clin Exp Urol. 2014 Oct 2;2(3):169-87. eCollection 2014. Am J Clin Exp Urol. 2014. PMID: 25374920 Free PMC article. Review.
These NCoR/SMRT-interacting proteins also show deregulated functions in cancers. In this review, we summarize the literature on the mechanism, regulation, and function of the core components of NCoR/SMRT complexes in the context of their involvement in cancers and l …
These NCoR/SMRT-interacting proteins also show deregulated functions in cancers. In this review, we summarize the literature on the m …
Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4.
Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E. Huang Z, et al. Nucleic Acids Res. 2023 Feb 22;51(3):1067-1086. doi: 10.1093/nar/gkac1230. Nucleic Acids Res. 2023. PMID: 36610795 Free PMC article.
In this study, we discover that G protein pathway suppressor 2 (GPS2), a core subunit of the HDAC3 corepressor complex assembled by SMRT and NCOR, represses IL4-dependent enhancer activation in mouse macrophages. Our genome-wide and gene-specific characterization revealed …
In this study, we discover that G protein pathway suppressor 2 (GPS2), a core subunit of the HDAC3 corepressor complex assembled by S …
ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I. Liu XF, et al. PLoS One. 2012;7(5):e38130. doi: 10.1371/journal.pone.0038130. Epub 2012 May 30. PLoS One. 2012. PMID: 22666460 Free PMC article.
Adipogenesis of 3T3-L1 cells was increased by selective down-regulation of Ankrd26, Trio, Gps2, Hmmr and Dipa. Furthermore, GPS2 and DIPA, which are normally located in the nucleus, were translocated to the cytoplasm, when the C-terminus of ANKRD26 was introduced in …
Adipogenesis of 3T3-L1 cells was increased by selective down-regulation of Ankrd26, Trio, Gps2, Hmmr and Dipa. Furthermore, GPS2 …
G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
Huang XD, Xiao FJ, Wang SX, Yin RH, Lu CR, Li QF, Liu N, Zhang Y, Wang LS, Li PY. Huang XD, et al. Tumour Biol. 2016 Oct;37(10):13333-13343. doi: 10.1007/s13277-016-5220-x. Epub 2016 Jul 26. Tumour Biol. 2016. PMID: 27460081 Free PMC article.
In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potenti …
In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without signifi …
Pseudogene-gene functional networks are prognostic of patient survival in breast cancer.
Smerekanych S, Johnson TS, Huang K, Zhang Y. Smerekanych S, et al. BMC Med Genomics. 2020 Apr 3;13(Suppl 5):51. doi: 10.1186/s12920-020-0687-0. BMC Med Genomics. 2020. PMID: 32241256 Free PMC article.
BACKGROUND: Given the vast range of molecular mechanisms giving rise to breast cancer, it is unlikely universal cures exist. However, by providing a more precise prognosis for breast cancer patients through integrative models, treatments can become more individualiz …
BACKGROUND: Given the vast range of molecular mechanisms giving rise to breast cancer, it is unlikely universal cures exist. However, …
Statistically identifying tumor suppressors and oncogenes from pan-cancer genome-sequencing data.
Kumar RD, Searleman AC, Swamidass SJ, Griffith OL, Bose R. Kumar RD, et al. Bioinformatics. 2015 Nov 15;31(22):3561-8. doi: 10.1093/bioinformatics/btv430. Epub 2015 Jul 25. Bioinformatics. 2015. PMID: 26209800 Free PMC article.
A method which accounts for these subclasses could improve performance while also suggesting a mechanism of action for new putative cancer genes. RESULTS: We develop a panel of five complementary statistical tests and assess their performance against a curated set of 99 Hi …
A method which accounts for these subclasses could improve performance while also suggesting a mechanism of action for new putative cance …
45 results