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GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.
Khanna P, Lee JS, Sereemaspun A, Lee H, Baeg GH. Khanna P, et al. Sci Rep. 2018 Jun 22;8(1):9511. doi: 10.1038/s41598-018-27864-6. Sci Rep. 2018. PMID: 29934528 Free PMC article.
Here, we showed that GRAMD1B expression is upregulated on IL-6 but downregulated upon treatment with the JAK2 inhibitor AG490 in the breast cancer MDA-MB-231 cells. ...Interestingly, AG490 dose-dependently increased p-Akt levels, and our epistasis analysis suggested …
Here, we showed that GRAMD1B expression is upregulated on IL-6 but downregulated upon treatment with the JAK2 inhibitor AG490 in the …
MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B.
Jonas K, Prinz F, Ferracin M, Krajina K, Deutsch A, Madl T, Rinner B, Slaby O, Klec C, Pichler M. Jonas K, et al. Noncoding RNA. 2023 Dec 26;10(1):2. doi: 10.3390/ncrna10010002. Noncoding RNA. 2023. PMID: 38250802 Free PMC article.
A type of cancer that is still in urgent need of improved treatment options is triple negative breast cancer (TNBC). ...We thus conclude that GRAMD1B may partly contribute to the diverse tumor-suppressive effects of miR-4646-5p in TNBC....
A type of cancer that is still in urgent need of improved treatment options is triple negative breast cancer (TNBC). ...We thu …
GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis.
Khanna P, Chua PJ, Wong BSE, Yin C, Thike AA, Wan WK, Tan PH, Baeg GH. Khanna P, et al. Oncotarget. 2017 Dec 15;8(70):115370-115383. doi: 10.18632/oncotarget.23265. eCollection 2017 Dec 29. Oncotarget. 2017. PMID: 29383166 Free PMC article.
Consistently, GRAMD1B and JAK/STAT signaling acted synergistically to promote gastric cancer cell survival by upregulating the expression of the anti-apoptotic molecule Bcl-xL. ...GRAMD1B expression levels were also found to be significantly associated with c …
Consistently, GRAMD1B and JAK/STAT signaling acted synergistically to promote gastric cancer cell survival by upregulating the …
Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma.
Suresh S, Rabbie R, Garg M, Lumaquin D, Huang TH, Montal E, Ma Y, Cruz NM, Tang X, Nsengimana J, Newton-Bishop J, Hunter MV, Zhu Y, Chen K, de Stanchina E, Adams DJ, White RM. Suresh S, et al. Cancer Discov. 2023 Jan 9;13(1):194-215. doi: 10.1158/2159-8290.CD-22-0427. Cancer Discov. 2023. PMID: 36259947 Free PMC article.
Using a zebrafish model of primary melanoma, we interrogated the top genes from the AVAST-M signature in vivo. This identified GRAMD1B, a cholesterol transfer protein, as a bona fide metastasis suppressor, with a majority of knockout animals rapidly developing metastasis. …
Using a zebrafish model of primary melanoma, we interrogated the top genes from the AVAST-M signature in vivo. This identified GRAMD1B …
Molecular characterization of extracellular vesicles derived from follicular fluid of women with and without PCOS: integrating analysis of differential miRNAs and proteins reveals vital molecules involving in PCOS.
Yang Y, Lang P, Zhang X, Wu X, Cao S, Zhao C, Shen R, Ling X, Yang Y, Zhang J. Yang Y, et al. J Assist Reprod Genet. 2023 Mar;40(3):537-552. doi: 10.1007/s10815-023-02724-z. Epub 2023 Jan 25. J Assist Reprod Genet. 2023. PMID: 36695944 Free PMC article.
In the analysis integrating DEmiRNAs target genes and DEPs, two molecules, GRAMD1B and STPLC2, attracted our attention that are closely associated with cholesterol transport and ceramide biosynthesis, respectively. CONCLUSION: Dysregulated miRNAs and proteins in FF-EVs, ma …
In the analysis integrating DEmiRNAs target genes and DEPs, two molecules, GRAMD1B and STPLC2, attracted our attention that are close …
Construction and evaluation of a prognostic risk model of tumor metastasis-related genes in patients with non-small cell lung cancer.
Ding H, Shi L, Chen Z, Lu Y, Tian Z, Xiao H, Deng X, Chen P, Zhang Y. Ding H, et al. BMC Med Genomics. 2022 Sep 2;15(1):187. doi: 10.1186/s12920-022-01341-6. BMC Med Genomics. 2022. PMID: 36056349 Free PMC article.
BACKGROUND: Lung cancer is a high-incidence cancer, and it is also the most common cause of cancer death worldwide. 80-85% of lung cancer cases can be classified as non-small cell lung cancer (NSCLC). ...GO functions and KEGG pathways analysis r …
BACKGROUND: Lung cancer is a high-incidence cancer, and it is also the most common cause of cancer death worldwide. 80- …
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.
Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter CE, Spiegel S, Platt FM, Eden ER. Höglinger D, et al. Nat Commun. 2019 Sep 19;10(1):4276. doi: 10.1038/s41467-019-12152-2. Nat Commun. 2019. PMID: 31537798 Free PMC article.
We report a role for Niemann-Pick type C protein 1 (NPC1) in tethering ER-endocytic organelle MCS where it interacts with the ER-localised sterol transport protein Gramd1b to regulate cholesterol egress. We show that artificially tethering MCS rescues the cholesterol accum …
We report a role for Niemann-Pick type C protein 1 (NPC1) in tethering ER-endocytic organelle MCS where it interacts with the ER-localised s …
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. Wu SY, et al. Nat Commun. 2014 Mar 12;5:3459. doi: 10.1038/ncomms4459. Nat Commun. 2014. PMID: 24619206 Free PMC article.
We demonstrate the therapeutic utility of MePS2 siRNAs in chemoresistant ovarian cancer mouse models via targeting GRAM domain containing 1B (GRAMD1B), a protein involved in chemoresistance. GRAMD1B silencing is achieved in tumours following MePS2-modified si …
We demonstrate the therapeutic utility of MePS2 siRNAs in chemoresistant ovarian cancer mouse models via targeting GRAM domain contai …
Uncovering the Gut-Liver Axis Biomarkers for Predicting Metabolic Burden in Mice.
Yang G, Liu R, Rezaei S, Liu X, Wan YY. Yang G, et al. Nutrients. 2023 Jul 31;15(15):3406. doi: 10.3390/nu15153406. Nutrients. 2023. PMID: 37571345 Free PMC article.
The progression of MASLD can be escalated when those risks are combined. Inactivation of FXR, the receptor for bile acid (BA), is cancer prone in both humans and mice. The current study used multi-omics including hepatic transcripts, liver, serum, and urine metabolites, he …
The progression of MASLD can be escalated when those risks are combined. Inactivation of FXR, the receptor for bile acid (BA), is cancer …
Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.
Ziliak D, Gamazon ER, Lacroix B, Kyung Im H, Wen Y, Huang RS. Ziliak D, et al. Mol Cancer Ther. 2012 Sep;11(9):2054-61. doi: 10.1158/1535-7163.MCT-12-0221. Epub 2012 Jun 29. Mol Cancer Ther. 2012. PMID: 22752226 Free PMC article.
Platinum agents are the backbone of cancer chemotherapy. Recently, we identified and replicated the role of a single nucleotide polymorphism (SNP, rs1649942) in predicting platinum sensitivity both in vitro and in vivo. ...Further examination of miR-193b* in platinum sensi …
Platinum agents are the backbone of cancer chemotherapy. Recently, we identified and replicated the role of a single nucleotide polym …
16 results