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1989 1
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2000 3
2001 1
2002 1
2004 2
2005 6
2006 10
2007 5
2008 11
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169 results

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Page 1
GABRA3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases.
Liu L, Yang C, Shen J, Huang L, Lin W, Tang H, Liang W, Shao W, Zhang H, He J. Liu L, et al. Oncotarget. 2016 May 31;7(22):32341-50. doi: 10.18632/oncotarget.8700. Oncotarget. 2016. PMID: 27081042 Free PMC article.
Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with dise …
Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly u …
The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis.
Gumireddy K, Li A, Kossenkov AV, Sakurai M, Yan J, Li Y, Xu H, Wang J, Zhang PJ, Zhang L, Showe LC, Nishikura K, Huang Q. Gumireddy K, et al. Nat Commun. 2016 Feb 12;7:10715. doi: 10.1038/ncomms10715. Nat Commun. 2016. PMID: 26869349 Free PMC article.
Importantly, we find an A-to-I RNA-edited form of Gabra3 only in non-invasive breast cancers and show that edited Gabra3 suppresses breast cancer cell invasion and metastasis. ...Our study demonstrates a significant role for mRNA-edited Gabra3 in breast cance …
Importantly, we find an A-to-I RNA-edited form of Gabra3 only in non-invasive breast cancers and show that edited Gabra3 suppr …
miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer.
Long M, Zhan M, Xu S, Yang R, Chen W, Zhang S, Shi Y, He Q, Mohan M, Liu Q, Wang J. Long M, et al. Mol Cancer. 2017 Oct 27;16(1):167. doi: 10.1186/s12943-017-0723-7. Mol Cancer. 2017. PMID: 29078789 Free PMC article.
BACKGROUND: MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic cancer (PC). Our previous study demonstrated that Gabra3 …
BACKGROUND: MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and …
Rare GABRA3 variants are associated with epileptic seizures, encephalopathy and dysmorphic features.
Niturad CE, Lev D, Kalscheuer VM, Charzewska A, Schubert J, Lerman-Sagie T, Kroes HY, Oegema R, Traverso M, Specchio N, Lassota M, Chelly J, Bennett-Back O, Carmi N, Koffler-Brill T, Iacomino M, Trivisano M, Capovilla G, Striano P, Nawara M, Rzonca S, Fischer U, Bienek M, Jensen C, Hu H, Thiele H, Altmüller J, Krause R, May P, Becker F; EuroEPINOMICS Consortium; Balling R, Biskup S, Haas SA, Nürnberg P, van Gassen KLI, Lerche H, Zara F, Maljevic S, Leshinsky-Silver E. Niturad CE, et al. Brain. 2017 Nov 1;140(11):2879-2894. doi: 10.1093/brain/awx236. Brain. 2017. PMID: 29053855
Accordingly, several genes coding for GABAA receptor subunits have been linked to a spectrum of benign to severe epileptic disorders and it was shown that a loss of function presents the major correlated pathomechanism. Here, we identified six variants in GABRA3 encoding t …
Accordingly, several genes coding for GABAA receptor subunits have been linked to a spectrum of benign to severe epileptic disorders and it …
Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.
Fain JS, Van Tongelen A, Loriot A, De Smet C. Fain JS, et al. Cytogenet Genome Res. 2019;159(1):12-18. doi: 10.1159/000502933. Epub 2019 Oct 9. Cytogenet Genome Res. 2019. PMID: 31593956
According to the latest genome annotation, CT- GABRA3 starts near MAGEA3, with which it shares a bidirectional promoter. ...We found that in tumor tissues and cell lines of different origins, the expression of CT-GABRA3 was better correlated with that of MAGEA6. Mor …
According to the latest genome annotation, CT- GABRA3 starts near MAGEA3, with which it shares a bidirectional promoter. ...We found …
MiR-92b inhibited cells EMT by targeting Gabra3 and predicted prognosis of triple negative breast cancer patients.
Li YY, Zheng XH, Deng AP, Wang Y, Liu J, Zhou Q, Cheng GY, Jiang Q. Li YY, et al. Eur Rev Med Pharmacol Sci. 2019 Dec;23(23):10433-10442. doi: 10.26355/eurrev_201912_19682. Eur Rev Med Pharmacol Sci. 2019. PMID: 31841197 Free article.
The expression of miR-92b had a negative correlation with the expression of Gabra3 in TNBC tissues. Downregulation of Gabra3 could inhibit the migration, invasion and EMT of TNBC cells. MiR-92b mediated the expression of Gabra3 through directly binding to the …
The expression of miR-92b had a negative correlation with the expression of Gabra3 in TNBC tissues. Downregulation of Gabra3 c …
Global RNA editome landscape discovers reduced RNA editing in glioma: loss of editing of gamma-amino butyric acid receptor alpha subunit 3 (GABRA3) favors glioma migration and invasion.
Patil V, Pal J, Mahalingam K, Somasundaram K. Patil V, et al. PeerJ. 2020 Sep 29;8:e9755. doi: 10.7717/peerj.9755. eCollection 2020. PeerJ. 2020. PMID: 33062411 Free PMC article.
Further, GABRA3 transcripts were observed to be higher in edited compared to unedited glioma samples. The transcript and protein levels of exogenously expressed gene were found to be higher for edited compared to unedited GABRA3 in glioma cells. Further, exogenously …
Further, GABRA3 transcripts were observed to be higher in edited compared to unedited glioma samples. The transcript and protein leve …
Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Miller BH, Schultz LE, Long BC, Pletcher MT. Miller BH, et al. Mamm Genome. 2010 Jun;21(5-6):247-57. doi: 10.1007/s00335-010-9266-6. Epub 2010 May 29. Mamm Genome. 2010. PMID: 20512339 Free PMC article.
To verify the role of Gabra3 in regulating TST behavior in vivo, mice were treated with SB-205384, a positive modulator of the alpha3 subunit. SB-205384 significantly reduced TST immobility in B6 mice without affecting general activity, but it had no effect on behavior in …
To verify the role of Gabra3 in regulating TST behavior in vivo, mice were treated with SB-205384, a positive modulator of the alpha3 …
Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population.
Jongjaroenprasert W, Chanprasertyotin S, Butadej S, Nakasatien S, Charatcharoenwitthaya N, Himathongkam T, Ongphiphadhanakul B. Jongjaroenprasert W, et al. Clin Endocrinol (Oxf). 2008 Apr;68(4):646-51. doi: 10.1111/j.1365-2265.2007.03083.x. Epub 2007 Oct 29. Clin Endocrinol (Oxf). 2008. PMID: 17970773
SNP rs750841 (A > T) in intron 3 of the gamma-aminobutyric acid (GABA) receptor alpha3 subunit (GABRA3) gene possessed the most significant difference in allele frequency (27% in THPP case and 5% in controls, P = 0.007). ...CONCLUSIONS: Whole-genome scanning on pooled D …
SNP rs750841 (A > T) in intron 3 of the gamma-aminobutyric acid (GABA) receptor alpha3 subunit (GABRA3) gene possessed the most si …
Lack of association between GABRA3 and unipolar affective disorder: a multicentre study.
Massat I, Souery D, Del-Favero J, Oruc L, Jakovljevic M, Folnegovic V, Adolfsson R, Kaneva R, Papadimitriou G, Dikeos D, Jazin E, Milanova V, Van Broeckhoven C, Mendlewicz J. Massat I, et al. Int J Neuropsychopharmacol. 2001 Sep;4(3):273-8. doi: 10.1017/S1461145701002449. Int J Neuropsychopharmacol. 2001. PMID: 11602034 Free article. Clinical Trial.
Available data on gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in the brain GABAergic system activity contributes to vulnerability to affective disorders (AD), including bipolar disorder (BPAD) and unipolar disorder (UPAD). The localization of the alp …
Available data on gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in the brain GABAergic system activity contribut …
169 results