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High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation.
Eur J Pharm Sci. 2018 Oct 15;123:268-276. doi: 10.1016/j.ejps.2018.07.048. Epub 2018 Jul 24.
Eur J Pharm Sci. 2018.
PMID: 30048801
Free PMC article.
Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity.
Gadd AJ, Greco F, Cobb AJ, Edwards AD.
Gadd AJ, et al.
Bioconjug Chem. 2015 Aug 19;26(8):1743-52. doi: 10.1021/acs.bioconjchem.5b00302. Epub 2015 Jul 16.
Bioconjug Chem. 2015.
PMID: 26133029
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UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion.
Dahal LN, Gadd A, Edwards AD, Cragg MS, Beers SA.
Dahal LN, et al.
Scand J Immunol. 2018 Jun;87(6):e12666. doi: 10.1111/sji.12666. Epub 2018 May 6.
Scand J Immunol. 2018.
PMID: 29667229
Free article.
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