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Epigenetic Mechanisms beyond Tumour-Stroma Crosstalk.
Gagliano T, Brancolini C. Gagliano T, et al. Cancers (Basel). 2021 Feb 22;13(4):914. doi: 10.3390/cancers13040914. Cancers (Basel). 2021. PMID: 33671588 Free PMC article. Review.
To occur, epigenetic events need to be triggered by genetic alterations of the epigenetic regulators, or they can be mediated by intracellular and extracellular stimuli. In this last setting, the tumour microenvironment (TME) plays a fundamental role. Therefore, to deciphe …
To occur, epigenetic events need to be triggered by genetic alterations of the epigenetic regulators, or they can be mediated by intracellul …
HDACs and the epigenetic plasticity of cancer cells: Target the complexity.
Brancolini C, Gagliano T, Minisini M. Brancolini C, et al. Among authors: gagliano t. Pharmacol Ther. 2022 Oct;238:108190. doi: 10.1016/j.pharmthera.2022.108190. Epub 2022 Apr 14. Pharmacol Ther. 2022. PMID: 35430294 Free article. Review.
Cancer cells must adapt to the hostile conditions of the microenvironment in terms of nutrition, space, and immune system attack. ...
Cancer cells must adapt to the hostile conditions of the microenvironment in terms of nutrition, space, and immune system attack. ...
Decoding the Tumour Microenvironment: Molecular Players, Pathways, and Therapeutic Targets in Cancer Treatment.
Malavasi E, Adamo M, Zamprogno E, Vella V, Giamas G, Gagliano T. Malavasi E, et al. Among authors: gagliano t. Cancers (Basel). 2024 Jan 31;16(3):626. doi: 10.3390/cancers16030626. Cancers (Basel). 2024. PMID: 38339377 Free PMC article. Review.
The tumour microenvironment (TME) is a complex and constantly evolving collection of cells and extracellular components. ...
The tumour microenvironment (TME) is a complex and constantly evolving collection of cells and extracellular components. ...
Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9.
Brancolini C, Di Giorgio E, Formisano L, Gagliano T. Brancolini C, et al. Among authors: gagliano t. Life (Basel). 2021 Jan 27;11(2):90. doi: 10.3390/life11020090. Life (Basel). 2021. PMID: 33513699 Free PMC article. Review.
Since its discovery, different phenotypes and/or dysfunctions have been observed after the artificial manipulation of its expression. The cells and the microenvironment use multiple strategies to control and monitor HDAC9 activities. ...
Since its discovery, different phenotypes and/or dysfunctions have been observed after the artificial manipulation of its expression. The ce …
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression.
Gagliano T, Shah K, Gargani S, Lao L, Alsaleem M, Chen J, Ntafis V, Huang P, Ditsiou A, Vella V, Yadav K, Bienkowska K, Bresciani G, Kang K, Li L, Carter P, Benstead-Hume G, O'Hanlon T, Dean M, Pearl FM, Lee SC, Rakha EA, Green AR, Kontoyiannis DL, Song E, Stebbing J, Giamas G. Gagliano T, et al. J Clin Invest. 2020 Jun 1;130(6):3188-3204. doi: 10.1172/JCI128313. J Clin Invest. 2020. PMID: 32125284 Free PMC article.
As there is growing evidence for the tumor microenvironment's role in tumorigenesis, we investigated the role of fibroblast-expressed kinases in triple-negative breast cancer (TNBC). ...
As there is growing evidence for the tumor microenvironment's role in tumorigenesis, we investigated the role of fibroblast-ex …