Gajate C - Search Results

1

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.

Mitsiades CS, Ocio EM, Pandiella A, Maiso P, Gajate C, Garayoa M, Vilanova D, Montero JC, Mitsiades N, McMullan CJ, Munshi NC, Hideshima T, Chauhan D, Aviles P, Otero G, Faircloth G, Mateos MV, Richardson PG, Mollinedo F, San-Miguel JF, Anderson KC. Mitsiades CS, et al. Among authors: gajate c. Cancer Res. 2008 Jul 1;68(13):5216-25. doi: 10.1158/0008-5472.CAN-07-5725. Cancer Res. 2008. PMID: 18593922

2

The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells.

Mollinedo F, Gajate C, Modolell M. Mollinedo F, et al. Among authors: gajate c. Biochem J. 1994 Sep 1;302 ( Pt 2)(Pt 2):325-9. doi: 10.1042/bj3020325. Biochem J. 1994. PMID: 8092982 Free PMC article.

3

Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

Mollinedo F, Fernández-Luna JL, Gajate C, Martín-Martín B, Benito A, Martínez-Dalmau R, Modolell M. Mollinedo F, et al. Among authors: gajate c. Cancer Res. 1997 Apr 1;57(7):1320-8. Cancer Res. 1997. PMID: 9102220

4

Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis.

Gajate C, Fonteriz RI, Cabaner C, Alvarez-Noves G, Alvarez-Rodriguez Y, Modolell M, Mollinedo F. Gajate C, et al. Int J Cancer. 2000 Mar 1;85(5):674-82. doi: 10.1002/(sici)1097-0215(20000301)85:5<674::aid-ijc13>3.0.co;2-z. Int J Cancer. 2000. PMID: 10699948 Free article.

5

Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest.

Gajate C, Barasoain I, Andreu JM, Mollinedo F. Gajate C, et al. Cancer Res. 2000 May 15;60(10):2651-9. Cancer Res. 2000. PMID: 10825137

6

The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.

Gajate C, Mollinedo F. Gajate C, et al. Blood. 2001 Dec 15;98(13):3860-3. doi: 10.1182/blood.v98.13.3860. Blood. 2001. PMID: 11739199 Free article.

7

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

Gajate C, An F, Mollinedo F. Gajate C, et al. J Biol Chem. 2002 Nov 1;277(44):41580-9. doi: 10.1074/jbc.M204644200. Epub 2002 Aug 26. J Biol Chem. 2002. PMID: 12198119 Free article.

8

Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells.

Gajate C, Mollinedo F. Gajate C, et al. Curr Drug Metab. 2002 Oct;3(5):491-525. doi: 10.2174/1389200023337225. Curr Drug Metab. 2002. PMID: 12369895 Free article. Review.

9

Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.

Gajate C, An F, Mollinedo F. Gajate C, et al. Clin Cancer Res. 2003 Apr;9(4):1535-45. Clin Cancer Res. 2003. PMID: 12684430

10

Microtubules, microtubule-interfering agents and apoptosis.

Mollinedo F, Gajate C. Mollinedo F, et al. Among authors: gajate c. Apoptosis. 2003 Oct;8(5):413-50. doi: 10.1023/a:1025513106330. Apoptosis. 2003. PMID: 12975575 Review.

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