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Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A, Guarini S. Giuliani D, et al. Among authors: galantucci m. Br J Pharmacol. 2007 Mar;150(5):595-603. doi: 10.1038/sj.bjp.0707115. Epub 2007 Jan 22. Br J Pharmacol. 2007. PMID: 17245369 Free PMC article.
Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.
Giuliani D, Leone S, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Altavilla D, Galantucci M, Minutoli L, Bitto A, Squadrito F, Guarini S. Giuliani D, et al. Among authors: galantucci m. Eur J Pharmacol. 2006 May 24;538(1-3):48-56. doi: 10.1016/j.ejphar.2006.03.038. Epub 2006 Mar 24. Eur J Pharmacol. 2006. PMID: 16647700
Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268.
Giuliani D, Ottani A, Minutoli L, Stefano VD, Galantucci M, Bitto A, Zaffe D, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Giuliani D, et al. Among authors: galantucci m. Brain Behav Immun. 2009 Aug;23(6):844-50. doi: 10.1016/j.bbi.2009.03.009. Epub 2009 Apr 5. Brain Behav Immun. 2009. PMID: 19345727
Melanocortins protect against multiple organ dysfunction syndrome in mice.
Bitto A, Polito F, Altavilla D, Irrera N, Giuliani D, Ottani A, Minutoli L, Spaccapelo L, Galantucci M, Lodi R, Guzzo G, Guarini S, Squadrito F. Bitto A, et al. Among authors: galantucci m. Br J Pharmacol. 2011 Feb;162(4):917-28. doi: 10.1111/j.1476-5381.2010.01098.x. Br J Pharmacol. 2011. PMID: 21039420 Free PMC article.
Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery.
Giuliani D, Zaffe D, Ottani A, Spaccapelo L, Galantucci M, Minutoli L, Bitto A, Irrera N, Contri M, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Giuliani D, et al. Among authors: galantucci m. Acta Neuropathol. 2011 Oct;122(4):443-53. doi: 10.1007/s00401-011-0873-4. Epub 2011 Sep 17. Acta Neuropathol. 2011. PMID: 21927944
Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia.
Spaccapelo L, Bitto A, Galantucci M, Ottani A, Irrera N, Minutoli L, Altavilla D, Novellino E, Grieco P, Zaffe D, Squadrito F, Giuliani D, Guarini S. Spaccapelo L, et al. Among authors: galantucci m. Eur J Pharmacol. 2011 Nov 30;670(2-3):479-86. doi: 10.1016/j.ejphar.2011.09.015. Epub 2011 Sep 21. Eur J Pharmacol. 2011. PMID: 21946115
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