Ganesh T - Search Results

1

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus.

Jiang J, Yang MS, Quan Y, Gueorguieva P, Ganesh T, Dingledine R. Jiang J, et al. Among authors: ganesh t. Neurobiol Dis. 2015 Apr;76:126-136. doi: 10.1016/j.nbd.2014.12.032. Epub 2015 Jan 17. Neurobiol Dis. 2015. PMID: 25600211 Free PMC article.

2

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A. Ganesh T, et al. Bioorg Med Chem. 2008 Jul 15;16(14):6903-10. doi: 10.1016/j.bmc.2008.05.047. Epub 2008 May 27. Bioorg Med Chem. 2008. PMID: 18571929 Free PMC article.

3

Cancer and virus leads by HTS, chemical design and SEA data mining.

Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L, Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Thepchatri P, et al. Among authors: ganesh t. Curr Top Med Chem. 2009;9(13):1159-71. doi: 10.2174/156802609789753581. Curr Top Med Chem. 2009. PMID: 19807668 Free PMC article. Review.

4

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

Jiang J, Ganesh T, Du Y, Thepchatri P, Rojas A, Lewis I, Kurtkaya S, Li L, Qui M, Serrano G, Shaw R, Sun A, Dingledine R. Jiang J, et al. Among authors: ganesh t. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2307-12. doi: 10.1073/pnas.0909310107. Epub 2010 Jan 14. Proc Natl Acad Sci U S A. 2010. PMID: 20080612 Free PMC article.

5

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

Jiang J, Ganesh T, Du Y, Quan Y, Serrano G, Qui M, Speigel I, Rojas A, Lelutiu N, Dingledine R. Jiang J, et al. Among authors: ganesh t. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3149-54. doi: 10.1073/pnas.1120195109. Epub 2012 Feb 8. Proc Natl Acad Sci U S A. 2012. PMID: 22323596 Free PMC article.

6

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.

Jiang J, Quan Y, Ganesh T, Pouliot WA, Dudek FE, Dingledine R. Jiang J, et al. Among authors: ganesh t. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-6. doi: 10.1073/pnas.1218498110. Epub 2013 Feb 11. Proc Natl Acad Sci U S A. 2013. PMID: 23401547 Free PMC article.

7

Discovery and characterization of carbamothioylacrylamides as EP₂ selective antagonists.

Ganesh T, Jiang J, Shashidharamurthy R, Dingledine R. Ganesh T, et al. ACS Med Chem Lett. 2013 Jul 11;4(7):616-621. doi: 10.1021/ml400112h. ACS Med Chem Lett. 2013. PMID: 23914286 Free PMC article.

8

Prostanoid receptor EP2 as a therapeutic target.

Ganesh T. Ganesh T. J Med Chem. 2014 Jun 12;57(11):4454-65. doi: 10.1021/jm401431x. Epub 2013 Dec 4. J Med Chem. 2014. PMID: 24279689 Free PMC article. Review.

9

Cyclooxygenase-2 in epilepsy.

Rojas A, Jiang J, Ganesh T, Yang MS, Lelutiu N, Gueorguieva P, Dingledine R. Rojas A, et al. Among authors: ganesh t. Epilepsia. 2014 Jan;55(1):17-25. doi: 10.1111/epi.12461. Epub 2013 Nov 8. Epilepsia. 2014. PMID: 24446952 Free PMC article. Review.

10

Lead optimization studies of cinnamic amide EP2 antagonists.

Ganesh T, Jiang J, Yang MS, Dingledine R. Ganesh T, et al. J Med Chem. 2014 May 22;57(10):4173-84. doi: 10.1021/jm5000672. Epub 2014 May 5. J Med Chem. 2014. PMID: 24773616 Free PMC article.

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