Garber E - Search Results

1

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

Pepinsky RB, Shao Z, Ji B, Wang Q, Meng G, Walus L, Lee X, Hu Y, Graff C, Garber E, Meier W, Mi S. Pepinsky RB, et al. Among authors: garber e. J Pharmacol Exp Ther. 2011 Nov;339(2):519-29. doi: 10.1124/jpet.111.183483. Epub 2011 Aug 1. J Pharmacol Exp Ther. 2011. PMID: 21807883

2

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.

Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Mi S, Graff C, Garber E. Pepinsky RB, et al. Among authors: garber e. Protein Sci. 2010 May;19(5):954-66. doi: 10.1002/pro.372. Protein Sci. 2010. PMID: 20198683 Free PMC article.

3

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

Pepinsky RB, Walus L, Shao Z, Ji B, Gu S, Sun Y, Wen D, Lee X, Wang Q, Garber E, Mi S. Pepinsky RB, et al. Among authors: garber e. Bioconjug Chem. 2011 Feb 16;22(2):200-10. doi: 10.1021/bc1002746. Epub 2011 Jan 21. Bioconjug Chem. 2011. PMID: 21254764

4

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.

Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, Wong WM, Wang L, Su H, Chu TH, Guo J, Zhang W, So KF, Pepinsky B, Shao Z, Graff C, Garber E, Jung V, Wu EX, Wu W. Mi S, et al. Among authors: garber e. Nat Med. 2007 Oct;13(10):1228-33. doi: 10.1038/nm1664. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906634

5

Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering.

Weinreb PH, Wen D, Qian F, Wildes CP, Garber EA, Walus L, Jung MY, Wang J, Relton JK, Amatucci J, Wang R, Porreca F, Silvian L, Meier W, Pepinsky RB, Lee DH. Weinreb PH, et al. Biotechnol Appl Biochem. 2010 Sep;57(1):31-45. doi: 10.1042/BA20100061. Biotechnol Appl Biochem. 2010. PMID: 20815818

6

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.

Pepinsky RB, Shapiro RI, Wang S, Chakraborty A, Gill A, Lepage DJ, Wen D, Rayhorn P, Horan GS, Taylor FR, Garber EA, Galdes A, Engber TM. Pepinsky RB, et al. J Pharm Sci. 2002 Feb;91(2):371-87. doi: 10.1002/jps.10052. J Pharm Sci. 2002. PMID: 11835197

7

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4.

Shapiro RI, Plavina T, Schlain BR, Pepinsky RB, Garber EA, Jarpe M, Hochman PS, Wehner NG, Bard F, Motter R, Yednock TA, Taylor FR. Shapiro RI, et al. J Pharm Biomed Anal. 2011 Apr 28;55(1):168-75. doi: 10.1016/j.jpba.2011.01.006. Epub 2011 Jan 19. J Pharm Biomed Anal. 2011. PMID: 21300512

8

Mapping sonic hedgehog-receptor interactions by steric interference.

Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA. Pepinsky RB, et al. Among authors: garber ea. J Biol Chem. 2000 Apr 14;275(15):10995-1001. doi: 10.1074/jbc.275.15.10995. J Biol Chem. 2000. PMID: 10753901 Free article.

9

Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells.

Wen D, Vecchi MM, Gu S, Su L, Dolnikova J, Huang YM, Foley SF, Garber E, Pederson N, Meier W. Wen D, et al. Among authors: garber e. J Biol Chem. 2009 Nov 20;284(47):32686-94. doi: 10.1074/jbc.M109.059360. Epub 2009 Sep 25. J Biol Chem. 2009. PMID: 19783658 Free PMC article.

10

Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity.

Williams KP, Rayhorn P, Chi-Rosso G, Garber EA, Strauch KL, Horan GS, Reilly JO, Baker DP, Taylor FR, Koteliansky V, Pepinsky RB. Williams KP, et al. Among authors: garber ea. J Cell Sci. 1999 Dec;112 ( Pt 23):4405-14. doi: 10.1242/jcs.112.23.4405. J Cell Sci. 1999. PMID: 10564658

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