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Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.
Castro J, Garcia-Caraballo S, Maddern J, Schober G, Lumsden A, Harrington A, Schmiel S, Lindstrom B, Adams J, Brierley SM. Castro J, et al. Among authors: garcia caraballo s. Pain. 2022 Jan 1;163(1):e72-e86. doi: 10.1097/j.pain.0000000000002314. Pain. 2022. PMID: 33863856 Free PMC article.
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. Osteen JD, et al. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6. Nature. 2016. PMID: 27281198 Free PMC article.
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.
Lee MC, McCubbin JA, Christensen AD, Poole DP, Rajasekhar P, Lieu T, Bunnett NW, Garcia-Caraballo S, Erickson A, Brierley SM, Saleh R, Achuthan A, Fleetwood AJ, Anderson RL, Hamilton JA, Cook AD. Lee MC, et al. J Immunol. 2017 May 1;198(9):3565-3575. doi: 10.4049/jimmunol.1602127. Epub 2017 Mar 20. J Immunol. 2017. PMID: 28320832 Free PMC article.
29 results