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Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.
Wicker LS, Moule CL, Fraser H, Penha-Goncalves C, Rainbow D, Garner VE, Chamberlain G, Hunter K, Howlett S, Clark J, Gonzalez-Munoz A, Cumiskey AM, Tiffen P, Howson J, Healy B, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB. Wicker LS, et al. Among authors: garner ve. Novartis Found Symp. 2005;267:57-65; discussion 65-75. doi: 10.1002/047002139x.ch6. Novartis Found Symp. 2005. PMID: 15999801
Type 1 diabetes genes and pathways shared by humans and NOD mice.
Wicker LS, Clark J, Fraser HI, Garner VE, Gonzalez-Munoz A, Healy B, Howlett S, Hunter K, Rainbow D, Rosa RL, Smink LJ, Todd JA, Peterson LB. Wicker LS, et al. Among authors: garner ve. J Autoimmun. 2005;25 Suppl:29-33. doi: 10.1016/j.jaut.2005.09.009. Epub 2005 Oct 28. J Autoimmun. 2005. PMID: 16257508 Review.
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS. Araki M, et al. J Immunol. 2009 Oct 15;183(8):5146-57. doi: 10.4049/jimmunol.0802610. Epub 2009 Sep 25. J Immunol. 2009. PMID: 19783679 Free PMC article.
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P. Yamanouchi J, et al. Among authors: garner ve. Nat Genet. 2007 Mar;39(3):329-37. doi: 10.1038/ng1958. Epub 2007 Feb 4. Nat Genet. 2007. PMID: 17277778 Free PMC article.