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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
Bicondylar Tibial Plateau Fractures: What Predicts Infection?
Olszewski N, Manzano G, Wilson E, Joseph N, Vallier H, Pawlak A, Kottmeier S, Miller A, Gary J, Namm J, Miller A, Gupte G, Rodriguez-Buitrago A, Obremskey W, Willier D 3rd, Marcantonio A, Phieffer L, Sheridan E, Li K, Karunakar M, Vargas-Hernandez J, Yuan B, Shapiro J, Pratson L, Friess D, Jenkins D, Leighton R, Alqudhaya R, Aljilani W, Mullis B, Gruenwald K, Ollivere B, Myint Y, Odom C, Spitler C, Suwak P, Shah S, Rocha D, Horwitz D, Tornetta P 3rd. Olszewski N, et al. J Am Acad Orthop Surg. 2022 Oct 15;30(20):e1311-e1318. doi: 10.5435/JAAOS-D-21-00432. Epub 2022 Aug 16. J Am Acad Orthop Surg. 2022. PMID: 36200819
The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.
Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A. Wieczorek M, et al. Sci Transl Med. 2016 Nov 16;8(365):365ra159. doi: 10.1126/scitranslmed.aag1093. Sci Transl Med. 2016. PMID: 27856798 Free PMC article.