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Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE. Bustamante-Marin XM, et al. Am J Hum Genet. 2019 Feb 7;104(2):229-245. doi: 10.1016/j.ajhg.2018.12.009. Epub 2019 Jan 18. Am J Hum Genet. 2019. PMID: 30665704 Free PMC article.
These results were recapitulated in Gas2l2(-/-) mouse tracheal epithelial cell (mTEC) cultures and in X. laevis embryos treated with Gas2l2 morpholinos. In mice, the absence of Gas2l2 caused neonatal death, and the conditional deletion of Gas2l2 impair …
These results were recapitulated in Gas2l2(-/-) mouse tracheal epithelial cell (mTEC) cultures and in X. laevis embryos treated with …
A Novel Homozygous Variant in GAS2L2 in Two Sisters with Primary Ciliary Dyskinesia.
Feng G, Xu Y, Saso S, Sasano H, Kondoh S, Itani H, Gotoh S, Nagao M, Ikejiri M, Tanabe M, Takeuchi K. Feng G, et al. Intern Med. 2022;61(18):2765-2769. doi: 10.2169/internalmedicine.8884-21. Epub 2022 Sep 15. Intern Med. 2022. PMID: 36104176 Free PMC article.
Genetic examinations of the family confirmed that the sisters both harbored a homozygous variant in the growth-arrest-specific 2-like 2 (GAS2L2) gene. This is the third report of a family with PCD caused by a GAS2L2 variant....
Genetic examinations of the family confirmed that the sisters both harbored a homozygous variant in the growth-arrest-specific 2-like 2 ( …
Mucociliary Wnt signaling promotes cilia biogenesis and beating.
Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H, Niehrs C. Seidl C, et al. Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2. Nat Commun. 2023. PMID: 36878953 Free PMC article.
Moreover, Wnt treatment improves ciliary function in X. tropicalis ciliopathy models of male infertility and primary ciliary dyskinesia (ccdc108, gas2l2). We conclude that X. tropicalis motile cilia are Wnt signaling organelles that transduce a distinct Wnt-Pp1 response... …
Moreover, Wnt treatment improves ciliary function in X. tropicalis ciliopathy models of male infertility and primary ciliary dyskinesia (ccd …
Growth arrest-specific 2 protein family: Structure and function.
Zhang N, Zhao C, Zhang X, Cui X, Zhao Y, Yang J, Gao X. Zhang N, et al. Cell Prolif. 2021 Jan;54(1):e12934. doi: 10.1111/cpr.12934. Epub 2020 Oct 25. Cell Prolif. 2021. PMID: 33103301 Free PMC article. Review.
There are four members in the GAS2 family, viz. GAS2, GAS2L1, GAS2L2 and GAS2L3. Although GAS2 is defined as a family of growth arrest-specific proteins, the significant differences in the expression patterns, interaction characteristics and biological issues or diseases a …
There are four members in the GAS2 family, viz. GAS2, GAS2L1, GAS2L2 and GAS2L3. Although GAS2 is defined as a family of growth arres …
Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis.
Zhao C, Zhang N, Cui X, Zhang X, Ren Y, Su C, He J, Zhang W, Sun X, Yang J, Gao X. Zhao C, et al. Cancer Med. 2021 Apr;10(8):2826-2839. doi: 10.1002/cam4.3829. Epub 2021 Mar 12. Cancer Med. 2021. PMID: 33713047 Free PMC article.
Herein, we first comprehensively explored the potential correlation between growth-arrest-specific two family genes (GAS2, GAS2L1, GAS2L2, GAS2L3) and gliomas by bioinformatics analysis and cellular experiments. ...
Herein, we first comprehensively explored the potential correlation between growth-arrest-specific two family genes (GAS2, GAS2L1, GAS2L2 …
Identification of Radioresponsive Genes in Esophageal Cancer from Longitudinal and Single Cell Exome Sequencing.
Yang L, Zhang X, MacKay M, Foox J, Hou Q, Zheng X, Zhou R, Huang M, Jing Z, Mason CE, Wu S. Yang L, et al. Int J Radiat Oncol Biol Phys. 2020 Nov 15;108(4):1103-1114. doi: 10.1016/j.ijrobp.2020.06.015. Epub 2020 Jun 17. Int J Radiat Oncol Biol Phys. 2020. PMID: 32561500 Clinical Trial.
RESULTS: Significant allelic changes were observed during clinical irradiation, with 42 recurrent radioresponsive genes (sensitive and resistant) identified in multiple patients, including NOTCH1, MAML3, CDKN2A, NFE2L2, GAS2L2, OBSCN and TP53, with the last 3 genes implica …
RESULTS: Significant allelic changes were observed during clinical irradiation, with 42 recurrent radioresponsive genes (sensitive and resis …
Discovery of Pathogenic Variants Associated with Idiopathic Recurrent Pregnancy Loss Using Whole-Exome Sequencing.
Lee JY, Moon J, Hu HJ, Ryu CS, Ko EJ, Ahn EH, Kim YR, Kim JH, Kim NK. Lee JY, et al. Int J Mol Sci. 2024 May 17;25(10):5447. doi: 10.3390/ijms25105447. Int J Mol Sci. 2024. PMID: 38791485 Free PMC article.
Interestingly, several of the detected genes were functionally clustered, including some with a secretory function (mucin 4; MUC4; rs200737893 G>A and hyaluronan-binding protein 2; HABP2; rs542838125 G>T), in which growth arrest-specific 2 Like 2 (GAS2L2; rs140842796 …
Interestingly, several of the detected genes were functionally clustered, including some with a secretory function (mucin 4; MUC4; rs2007378 …
GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.
Stroud MJ, Nazgiewicz A, McKenzie EA, Wang Y, Kammerer RA, Ballestrem C. Stroud MJ, et al. J Cell Sci. 2014 Jun 15;127(Pt 12):2672-82. doi: 10.1242/jcs.140558. Epub 2014 Apr 4. J Cell Sci. 2014. PMID: 24706950 Free PMC article.
By using fluorescence microscopy, we demonstrate that three members of this family, GAS2-like 1, GAS2-like 2 and GAS2-like 3 (G2L1, G2L2 and G2L3, also known as GAS2L1, GAS2L2 and GAS2L3, respectively) are differentially involved in mediating the crosstalk between F-actin …
By using fluorescence microscopy, we demonstrate that three members of this family, GAS2-like 1, GAS2-like 2 and GAS2-like 3 (G2L1, G2L2 and …
Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases.
Furfari A, Wan BA, Ding K, Wong A, Zhu L, Bezjak A, Wong R, Wilson CF, DeAngelis C, Azad A, Chow E, Charames GS. Furfari A, et al. Ann Palliat Med. 2017 Dec;6(Suppl 2):S240-S247. doi: 10.21037/apm.2017.09.04. Epub 2017 Sep 20. Ann Palliat Med. 2017. PMID: 29156912 Free article. Clinical Trial.
Significant SNVs associated with dexamethasone response were from genes involved in extracellular matrix (HAS1, ADAMTS16) and cytoskeleton regulation (GAS2L2). Identification of SNVs predictive of pain flare and dexamethasone response enables targeted prophylactic therapy …
Significant SNVs associated with dexamethasone response were from genes involved in extracellular matrix (HAS1, ADAMTS16) and cytoskeleton r …
11 results