Geacintov NE - Search Results

1

Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway.

Dreij K, Rhrissorrakrai K, Gunsalus KC, Geacintov NE, Scicchitano DA. Dreij K, et al. Among authors: geacintov ne. Carcinogenesis. 2010 Jun;31(6):1149-57. doi: 10.1093/carcin/bgq073. Epub 2010 Apr 9. Carcinogenesis. 2010. PMID: 20382639 Free PMC article.

2

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.

Schinecker TM, Perlow RA, Broyde S, Geacintov NE, Scicchitano DA. Schinecker TM, et al. Among authors: geacintov ne. Nucleic Acids Res. 2003 Oct 15;31(20):6004-15. doi: 10.1093/nar/gkg771. Nucleic Acids Res. 2003. PMID: 14530448 Free PMC article.

3

Site-specific benzo[a]pyrene diol epoxide-DNA adducts inhibit transcription elongation by bacteriophage T7 RNA polymerase.

Choi DJ, Marino-Alessandri DJ, Geacintov NE, Scicchitano DA. Choi DJ, et al. Among authors: geacintov ne. Biochemistry. 1994 Jan 25;33(3):780-7. doi: 10.1021/bi00169a020. Biochemistry. 1994. PMID: 8292606

4

DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.

Perlow RA, Kolbanovskii A, Hingerty BE, Geacintov NE, Broyde S, Scicchitano DA. Perlow RA, et al. Among authors: geacintov ne. J Mol Biol. 2002 Aug 2;321(1):29-47. doi: 10.1016/s0022-2836(02)00593-4. J Mol Biol. 2002. PMID: 12139931

5

Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions.

Roth RB, Amin S, Geacintov NE, Scicchitano DA. Roth RB, et al. Among authors: geacintov ne. Biochemistry. 2001 May 1;40(17):5200-7. doi: 10.1021/bi0024355. Biochemistry. 2001. PMID: 11318642

6

Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase.

Dimitri A, Jia L, Shafirovich V, Geacintov NE, Broyde S, Scicchitano DA. Dimitri A, et al. Among authors: geacintov ne. DNA Repair (Amst). 2008 Aug 2;7(8):1276-88. doi: 10.1016/j.dnarep.2008.04.007. Epub 2008 Jun 13. DNA Repair (Amst). 2008. PMID: 18555749 Free PMC article.

7

Incorrect base insertion and prematurely terminated transcripts during T7 RNA polymerase transcription elongation past benzo[a]pyrenediol epoxide-modified DNA.

Choi DJ, Roth RB, Liu T, Geacintov NE, Scicchitano DA. Choi DJ, et al. Among authors: geacintov ne. J Mol Biol. 1996 Nov 29;264(2):213-9. doi: 10.1006/jmbi.1996.0635. J Mol Biol. 1996. PMID: 8951371 Free article.

8

Construction and purification of site-specifically modified DNA templates for transcription assays.

Perlow RA, Schinecker TM, Kim SJ, Geacintov NE, Scicchitano DA. Perlow RA, et al. Among authors: geacintov ne. Nucleic Acids Res. 2003 Apr 1;31(7):e40. doi: 10.1093/nar/gng040. Nucleic Acids Res. 2003. PMID: 12655028 Free PMC article.

9

The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.

Perlow-Poehnelt RA, Likhterov I, Scicchitano DA, Geacintov NE, Broyde S. Perlow-Poehnelt RA, et al. Among authors: geacintov ne. J Biol Chem. 2004 Aug 27;279(35):36951-61. doi: 10.1074/jbc.M404332200. Epub 2004 Jun 21. J Biol Chem. 2004. PMID: 15210693 Free article.

10

Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.

Perlow-Poehnelt RA, Likhterov I, Wang L, Scicchitano DA, Geacintov NE, Broyde S. Perlow-Poehnelt RA, et al. Among authors: geacintov ne. J Biol Chem. 2007 Jan 12;282(2):1397-408. doi: 10.1074/jbc.M606769200. Epub 2006 Nov 6. J Biol Chem. 2007. PMID: 17090533 Free article.

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