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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 26
1978 3
1979 3
1980 4
1981 4
1982 12
1983 14
1984 9
1985 12
1986 17
1987 25
1988 40
1989 35
1990 62
1991 58
1992 49
1993 68
1994 55
1995 68
1996 71
1997 56
1998 64
1999 55
2000 62
2001 102
2002 103
2003 76
2004 72
2005 71
2006 77
2007 77
2008 77
2009 85
2010 79
2011 81
2012 77
2013 64
2014 61
2015 72
2016 69
2017 61
2018 70
2019 71
2020 57
2021 54
2022 51
2023 42
2024 22

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Page 1
Gemfibrozil.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risks Hum. 1996;66:427-44. IARC Monogr Eval Carcinog Risks Hum. 1996. PMID: 9097130 Free PMC article. Review. No abstract available.
Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.
Tornio A, Neuvonen PJ, Niemi M, Backman JT. Tornio A, et al. Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. doi: 10.1080/17425255.2016.1227791. Epub 2016 Aug 31. Expert Opin Drug Metab Toxicol. 2017. PMID: 27548563 Review.
This effect is due to mechanism-based inhibition of CYP2C8 by gemfibrozil 1-O-beta-glucuronide. In vivo, gemfibrozil is a fairly selective CYP2C8 inhibitor, which lacks significant inhibitory effect on other CYP enzymes. ...Moreover, gemfibrozil could be used …
This effect is due to mechanism-based inhibition of CYP2C8 by gemfibrozil 1-O-beta-glucuronide. In vivo, gemfibrozil is a fair …
Gemfibrozil in Combination with Statins-Is It Really Contraindicated?
Wiggins BS, Saseen JJ, Morris PB. Wiggins BS, et al. Curr Atheroscler Rep. 2016 Apr;18(4):18. doi: 10.1007/s11883-016-0571-8. Curr Atheroscler Rep. 2016. PMID: 26932225 Review.
Gemfibrozil is a lipid-modifying agent that belongs to the fibric acid derivative class. ...However, despite these concerns, there are situations in which the use of gemfibrozil in combination with a statin may be necessary. Understanding the metabolism of gemfib …
Gemfibrozil is a lipid-modifying agent that belongs to the fibric acid derivative class. ...However, despite these concerns, there ar …
Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms.
Ivraghi MS, Zamanian MY, Gupta R, Achmad H, Alsaab HO, Hjazi A, Romero-Parra RM, Alwaily ER, Hussien BM, Hakimizadeh E. Ivraghi MS, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14473. doi: 10.1111/cns.14473. Epub 2023 Oct 30. CNS Neurosci Ther. 2024. PMID: 37904726 Free PMC article. Review.
BACKGROUND: Gemfibrozil (Gem) is a drug that has been shown to activate PPAR-alpha, a nuclear receptor that plays a key role in regulating lipid metabolism. ...
BACKGROUND: Gemfibrozil (Gem) is a drug that has been shown to activate PPAR-alpha, a nuclear receptor that plays a key role in regul …
Gemfibrozil, stretching arms beyond lipid lowering.
Roy A, Pahan K. Roy A, et al. Immunopharmacol Immunotoxicol. 2009;31(3):339-51. doi: 10.1080/08923970902785253. Immunopharmacol Immunotoxicol. 2009. PMID: 19694602 Free PMC article. Review.
Gemfibrozil is long known for its ability to reduce the level of triglycerides in the blood circulation and to decrease the risk of hyperlipidemia. ...In this review, we have made an honest attempt to analyze various biological activities of gemfibrozil and associat …
Gemfibrozil is long known for its ability to reduce the level of triglycerides in the blood circulation and to decrease the risk of h …
Gemfibrozil-induced myopathy.
Magarian GJ, Lucas LM, Colley C. Magarian GJ, et al. Arch Intern Med. 1991 Sep;151(9):1873-4. Arch Intern Med. 1991. PMID: 1888257 Review.
A particularly severe form, often accompanied by rhabdomyolysis, has been reported with the use of lovastatin and gemfibrozil; however, as far as we know, no case has been documented with use of gemfibrozil alone. Herein, we report the first case (to our knowledge o …
A particularly severe form, often accompanied by rhabdomyolysis, has been reported with the use of lovastatin and gemfibrozil; howeve …
Gemfibrozil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia.
Todd PA, Ward A. Todd PA, et al. Drugs. 1988 Sep;36(3):314-39. doi: 10.2165/00003495-198836030-00004. Drugs. 1988. PMID: 3056692 Review.
In comparative studies with clofibrate similar reductions in plasma lipid levels have been observed, although these changes tend to be more favorable overall with gemfibrozil. Gastrointestinal symptoms and rash are the only side effects produced more frequently with gem …
In comparative studies with clofibrate similar reductions in plasma lipid levels have been observed, although these changes tend to be more …
Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells.
Bachmann CM, Janitschke D, Lauer AA, Erhardt T, Hartmann T, Grimm MOW, Grimm HS. Bachmann CM, et al. Int J Mol Sci. 2023 Feb 3;24(3):2972. doi: 10.3390/ijms24032972. Int J Mol Sci. 2023. PMID: 36769295 Free PMC article.
Gemfibrozil is a drug that has been used for over 40 years to lower triglycerides in blood. ...As triglycerides are stored in lipid-droplets, which are known to be associated with many diseases, such as Alzheimer's disease, cancer, fatty liver disease and type-2 diabetes, …
Gemfibrozil is a drug that has been used for over 40 years to lower triglycerides in blood. ...As triglycerides are stored in lipid-d …
Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
Shah MB. Shah MB. Biomolecules. 2022 Sep 1;12(9):1218. doi: 10.3390/biom12091218. Biomolecules. 2022. PMID: 36139056 Free PMC article. Review.
The lipid-regulating drug gemfibrozil is a useful medication for reducing high cholesterol and triglycerides in the blood. ...It is not clear how an acyl glucuronide metabolite of the drug gemfibrozil or clopidogrel interacts in the active site of CYP2C8 and selecti …
The lipid-regulating drug gemfibrozil is a useful medication for reducing high cholesterol and triglycerides in the blood. ...It is n …
Gemfibrozil. A reappraisal of its pharmacological properties and place in the management of dyslipidaemia.
Spencer CM, Barradell LB. Spencer CM, et al. Drugs. 1996 Jun;51(6):982-1018. doi: 10.2165/00003495-199651060-00009. Drugs. 1996. PMID: 8736620 Review.
In general, gemfibrozil has at least similar efficacy to bile acid sequestrants and other fibric acid derivatives. Comparisons with HMG-CoA reductase inhibitors show these agents to produce different effects on lipid profiles from gemfibrozil. Thus, gemfibrozil …
In general, gemfibrozil has at least similar efficacy to bile acid sequestrants and other fibric acid derivatives. Comparisons with H …
2,336 results