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Single-Soma Deep RNA sequencing of Human DRG Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying Somatosensation.
Yu H, Usoskin D, Nagi SS, Hu Y, Kupari J, Bouchatta O, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Rice FL, Olausson H, Ernfors P, Luo W. Yu H, et al. bioRxiv [Preprint]. 2023 Sep 28:2023.03.17.533207. doi: 10.1101/2023.03.17.533207. bioRxiv. 2023. PMID: 36993480 Free PMC article. Preprint.
In summary, by employing a novel soma sequencing method, we generated an unprecedented hDRG neuron atlas, providing new insights into human somatosensation, establishing a critical foundation for translational work, and clarifying human species-species properties....
In summary, by employing a novel soma sequencing method, we generated an unprecedented hDRG neuron atlas, providing new insights into …
Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis.
Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, di Pietro-Bachmann M, Enderby P, Fillingham J, Galli FL, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LMT, Kambanaros M, Kang EK, Khedr EM, Kong APH, Kukkonen T, Laganaro M, Lambon Ralph MA, Laska AC, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Shisler Marshall R, Mattioli F, Maviş İ, Meinzer M, Nilipour R, Noé E, Paik NJ, Palmer R, Papathanasiou I, Patrício BF, Martins IP, Price C, Jakovac TP, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, Wright HH. Brady MC, et al. Southampton (UK): National Institute for Health and Care Research; 2022 Sep. Southampton (UK): National Institute for Health and Care Research; 2022 Sep. PMID: 36223438 Free Books & Documents. Review.
LIMITATIONS: Data sets were graded as being at a low risk of bias but were predominantly based on highly selected research participants, assessments and interventions, thereby limiting generalisability. CONCLUSIONS: Frequency, intensity and dosage were associated with lang …
LIMITATIONS: Data sets were graded as being at a low risk of bias but were predominantly based on highly selected research participants, ass …
Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis.
RELEASE Collaborators; Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, Pietro-Bachmann MD, Enderby P, Fillingham J, Lucia Galli F, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LM, Kambanaros M, Kyoung Kang E, Khedr EM, Pak-Hin Kong A, Kukkonen T, Laganaro M, Lambon Ralph MA, Charlotte Laska A, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Shisler Marshall R, Mattioli F, Maviş İ, Meinzer M, Nilipour R, Noé E, Paik NJ, Palmer R, Papathanasiou I, Patricio B, Pavão Martins I, Price C, Prizl Jakovac T, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, Harris Wright H. RELEASE Collaborators, et al. Int J Stroke. 2022 Dec;17(10):1067-1077. doi: 10.1177/17474930221097477. Epub 2022 May 18. Int J Stroke. 2022. PMID: 35422175 Free PMC article. Review.
Consistencies across subgroups were also evident; greatest overall-language gains were associated with 20-to-50 SLT-h in total; auditory comprehension gains were generally observed when SLT > 9 h over 4 days/week. CONCLUSIONS: We observed a treatment response in most su …
Consistencies across subgroups were also evident; greatest overall-language gains were associated with 20-to-50 SLT-h in total; auditory com …
In vivo response of murine gamma delta T cells to a heat shock protein-derived peptide.
Fu YX, Cranfill R, Vollmer M, Van Der Zee R, O'Brien RL, Born W. Fu YX, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):322-6. doi: 10.1073/pnas.90.1.322. Proc Natl Acad Sci U S A. 1993. PMID: 8093560 Free PMC article.
However, the experimental evidence supporting this idea involved in vitro peptide responses of gamma delta T-cell hybridomas generated from unprimed spleen cells. Here, we report an attempt to elicit a gamma delta T-cell response in vivo by stimulation of adult C57BL/10 mi …
However, the experimental evidence supporting this idea involved in vitro peptide responses of gamma delta T-cell hybridomas generated …
Characterization of gamma delta T lymphocytes at the maternal-fetal interface.
Heyborne KD, Cranfill RL, Carding SR, Born WK, O'Brien RL. Heyborne KD, et al. J Immunol. 1992 Nov 1;149(9):2872-8. J Immunol. 1992. PMID: 1401918
To characterize the TCR-gamma delta repertoire in the placenta/decidua, we generated 21 TCR-gamma delta-bearing hybridomas from lymphocytes in this tissue. ...
To characterize the TCR-gamma delta repertoire in the placenta/decidua, we generated 21 TCR-gamma delta-bearing hybridomas from lymph …
Liver gamma delta T cells. TCR junctions reveal differences in heat shock protein-60-reactive cells in liver and spleen.
Roark CE, Vollmer MK, Cranfill RL, Carding SR, Born WK, O'Brien RL. Roark CE, et al. J Immunol. 1993 Jun 1;150(11):4867-75. J Immunol. 1993. PMID: 8496591
The liver of mice contains elevated percentages of gamma delta T cells when compared with peripheral lymphoid organs. We have now analyzed these cells clonally, by generating a random collection of liver gamma delta T cell hybridomas and sequencing the productively rearran …
The liver of mice contains elevated percentages of gamma delta T cells when compared with peripheral lymphoid organs. We have now analyzed t …
RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia.
Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, Pietro-Bachmann MD, Enderby P, Fillingham J, Galli FL, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LMT, Kambanaros M, Kang EK, Khedr EM, Kong AP, Kukkonen T, Laganaro M, Ralph MAL, Laska AC, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Marshall RS, Mattioli F, Maviş I, Meinzer M, Nilipour R, Noé E, Paik NJ, Palmer R, Papathanasiou I, Patricio BF, Martins IP, Price C, Jakovac TP, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, Wright HH. Brady MC, et al. Aphasiology. 2020 Feb;34(2):137-157. doi: 10.1080/02687038.2019.1643003. Aphasiology. 2020. PMID: 37560459 Free PMC article.
AIM: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. ...CONCLUSION: Our planned systematic-review-based IPD meta- and network meta-an …
AIM: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT interven …