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Year Number of Results
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71 results

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Gentianella acuta improves TAC-induced cardiac remodelling by regulating the Notch and PI3K/Akt/FOXO1/3 pathways.
Zhou WW, Dai C, Liu WZ, Zhang C, Zhang Y, Yang GS, Guo QH, Li S, Yang HX, Li AY. Zhou WW, et al. Biomed Pharmacother. 2022 Oct;154:113564. doi: 10.1016/j.biopha.2022.113564. Epub 2022 Aug 19. Biomed Pharmacother. 2022. PMID: 35988427 Free article.
Cardiac remodelling mainly manifests as excessive myocardial hypertrophy and fibrosis, which are associated with heart failure. Gentianella acuta (G. acuta) is reportedly effective in cardiac protection; however, the mechanism by which it protects against cardiac remodelli …
Cardiac remodelling mainly manifests as excessive myocardial hypertrophy and fibrosis, which are associated with heart failure. Gentianel …
Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts.
Zhang T, Zhang Y, Li S, Ge H, Song Q, Zhang Y, Yang G, Li A. Zhang T, et al. Phytomedicine. 2023 Sep;118:154923. doi: 10.1016/j.phymed.2023.154923. Epub 2023 Jun 16. Phytomedicine. 2023. PMID: 37352750
BACKGROUND: Continuous activation and inflammation of cardiac fibroblasts (CFs) are essential for myocardial fibrosis. Gentianella acuta (Michx.) Hiitonen (G. acuta), that contains xanthones with cardioprotective properties, a typical healthful herb extensively used to tre …
BACKGROUND: Continuous activation and inflammation of cardiac fibroblasts (CFs) are essential for myocardial fibrosis. Gentianella ac …
Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats.
Si M, Wu M, Huo Y, Li A, Guan S, Ma D, Ma Z. Si M, et al. Exp Ther Med. 2021 Nov;22(5):1259. doi: 10.3892/etm.2021.10694. Epub 2021 Sep 6. Exp Ther Med. 2021. PMID: 34603527 Free PMC article.
Gentianella acuta (G. acuta) has been widely used as a traditional medicine by Chinese Mongolian populations for the treatment of heart diseases and has also been tested in modern pharmacological experiments. ...
Gentianella acuta (G. acuta) has been widely used as a traditional medicine by Chinese Mongolian populations for the treatment of hea …
Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-B inflammatory signalling.
Sun JH, Yang HX, Yao TT, Li Y, Ruan L, Xu GR, Zhang C, Guo GX, Li AY. Sun JH, et al. Inflammopharmacology. 2021 Feb;29(1):205-219. doi: 10.1007/s10787-020-00708-4. Epub 2020 Apr 30. Inflammopharmacology. 2021. PMID: 32356088
Gentianella acuta (G. acuta), as a folk medicine, was used to treat heart disease by the Ewenki people in Inner Mongolia. ...
Gentianella acuta (G. acuta), as a folk medicine, was used to treat heart disease by the Ewenki people in Inner Mongolia. ...
Gentianella lutescens subsp. carpatica J. Holub.: Shoot Propagation In Vitro and Effect of Sucrose and Elicitors on Xanthones Production.
Krstić-Milošević D, Banjac N, Janković T, Vinterhalter D, Vinterhalter B. Krstić-Milošević D, et al. Plants (Basel). 2021 Aug 11;10(8):1651. doi: 10.3390/plants10081651. Plants (Basel). 2021. PMID: 34451696 Free PMC article.
In vitro shoot culture of the endangered medicinal plant Gentianella lutescens was established from epicotyl explants cultured on MS basal medium with 0.2 mg L(-1) 6-benzylaminopurine (BA) and evaluated for xanthones content for the first time. ...
In vitro shoot culture of the endangered medicinal plant Gentianella lutescens was established from epicotyl explants cultured on MS …
Gentianella macrosperma, a new species of Gentianella (Gentianaceae) from Xinjiang, China.
Cao HF, Ya JD, Zhang QR, Hu XJ, Zhang ZR, Liu XH, Zhang YC, Zhang AT, Yu WB. Cao HF, et al. PhytoKeys. 2019 Aug 29;130:59-73. doi: 10.3897/phytokeys.130.35476. eCollection 2019. PhytoKeys. 2019. PMID: 31534395 Free PMC article.
Gentianella macrosperma Ma ex H.F. Cao, J.D. Ya & Q.R. Zhang, a new species of Gentianaceae from Xinjiang, Northwest China is described and illustrated. ...In addition, an updated identification key to the Chinese species of Gentianella is provided....
Gentianella macrosperma Ma ex H.F. Cao, J.D. Ya & Q.R. Zhang, a new species of Gentianaceae from Xinjiang, Northwest China is des …
Gentianella turkestanerum Showed Protective Effects on Hepatic Injury by Modulating the Endoplasmic Reticulum Stress and NF-kappaB Signaling Pathway.
Yang J, Zhu D, Wen L, Xiang X, Hu J. Yang J, et al. Curr Mol Med. 2019;19(6):452-460. doi: 10.2174/1566524019666190415124838. Curr Mol Med. 2019. PMID: 30987565
OBJECTIVE: To investigate the protective effects of Gentianella turkestanerum extraction by butanol (designated as GBA) on hepatic cell line L02 injury induced by carbon tetrachloride (CCl4) and hydrogen peroxide (H2O2). ...
OBJECTIVE: To investigate the protective effects of Gentianella turkestanerum extraction by butanol (designated as GBA) on hepatic ce …
Bellidifolin from Gentianella acuta (Michx.) Hulten protects H9c2 cells from hydrogen peroxide-induced injury via the PI3K-Akt signal pathway.
Li S, Huang C, Li X, Meng X, Wen R, Zhang X, Zhang C, Li M. Li S, et al. Toxicol Rep. 2022 Aug 17;9:1655-1665. doi: 10.1016/j.toxrep.2022.08.006. eCollection 2022. Toxicol Rep. 2022. PMID: 36518482 Free PMC article.
Therefore, new drugs should be developed to treat cardiovascular disease. Gentianella acuta (Michx.) Hulten (G. acuta) is an important Mongolian medicine in China and elicits protective effects on cardiovascular health. ...
Therefore, new drugs should be developed to treat cardiovascular disease. Gentianella acuta (Michx.) Hulten (G. acuta) is an importan …
Xanthones from Gentianella acuta (Michx.) Hulten Ameliorate Colorectal Carcinoma via the PI3K/Akt/mTOR Signaling Pathway.
Lu MQ, Ruan JY, Li HM, Yang DS, Liu YX, Hao MM, Yu HY, Zhang Y, Wang T. Lu MQ, et al. Int J Mol Sci. 2023 Jan 23;24(3):2279. doi: 10.3390/ijms24032279. Int J Mol Sci. 2023. PMID: 36768602 Free PMC article.
Xanthone derivatives are one of the most promising therapeutic drugs which have been used in phase I/II clinical trials for cancer therapy. Our previous study indicated that the aerial parts of Gentianella acuta Michx. Hulten (GA) was rich in xanthones and showed a good th …
Xanthone derivatives are one of the most promising therapeutic drugs which have been used in phase I/II clinical trials for cancer therapy. …
Dammarane-type triterpenoids from Gentianella azurea.
Huang YJ, Lu H, Yu XL, Zhang SW, Wang WQ, Fen LY, Xuan LJ. Huang YJ, et al. J Nat Prod. 2014 May 23;77(5):1201-9. doi: 10.1021/np500077z. Epub 2014 May 7. J Nat Prod. 2014. PMID: 24806310
Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallogr …
Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17 …
71 results