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The use of knockout mouse technology to achieve tissue selective expression of angiotensin converting enzyme.
J Mol Cell Cardiol. 2004 Jun;36(6):781-9. doi: 10.1016/j.yjmcc.2004.02.013.
J Mol Cell Cardiol. 2004.
PMID: 15158118
Review.
Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme.
Fuchs S, Frenzel K, Xiao HD, Adams JW, Zhao H, Keshelava G, Teng L, Bernstein KE.
Fuchs S, et al. Among authors: keshelava g.
Curr Hypertens Rep. 2004 Apr;6(2):124-8. doi: 10.1007/s11906-004-0087-4.
Curr Hypertens Rep. 2004.
PMID: 15010016
Review.
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Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.
Xiao HD, Fuchs S, Campbell DJ, Lewis W, Dudley SC Jr, Kasi VS, Hoit BD, Keshelava G, Zhao H, Capecchi MR, Bernstein KE.
Xiao HD, et al. Among authors: keshelava g.
Am J Pathol. 2004 Sep;165(3):1019-32. doi: 10.1016/S0002-9440(10)63363-9.
Am J Pathol. 2004.
PMID: 15331425
Free PMC article.
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Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice.
Fuchs S, Xiao HD, Cole JM, Adams JW, Frenzel K, Michaud A, Zhao H, Keshelava G, Capecchi MR, Corvol P, Bernstein KE.
Fuchs S, et al. Among authors: keshelava g.
J Biol Chem. 2004 Apr 16;279(16):15946-53. doi: 10.1074/jbc.M400149200. Epub 2004 Feb 2.
J Biol Chem. 2004.
PMID: 14757757
Free article.
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